ID   A0A023BRN0_9FLAO        Unreviewed;      2035 AA.
AC   A0A023BRN0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:EZH72619.1};
GN   ORFNames=ATO12_21010 {ECO:0000313|EMBL:EZH72619.1};
OS   Aquimarina atlantica.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Aquimarina.
OX   NCBI_TaxID=1317122 {ECO:0000313|EMBL:EZH72619.1, ECO:0000313|Proteomes:UP000023541};
RN   [1] {ECO:0000313|EMBL:EZH72619.1, ECO:0000313|Proteomes:UP000023541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=22II-S11-z7 {ECO:0000313|EMBL:EZH72619.1,
RC   ECO:0000313|Proteomes:UP000023541};
RA   Lai Q.;
RT   "Aquimarina sp. 22II-S11-z7 Genome Sequencing.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EZH72619.1}.
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DR   EMBL; AQRA01000007; EZH72619.1; -; Genomic_DNA.
DR   STRING; 1317122.ATO12_21010; -.
DR   eggNOG; COG2373; Bacteria.
DR   Proteomes; UP000023541; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000023541}.
FT   DOMAIN          973..1113
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1262..1352
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          1228..1251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1230..1250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2035 AA;  234148 MW;  1D8EDE5A39C6213C CRC64;
     MKKHIILIII CISNLYIMKG QNDYQSDWKK VETFNQEGLP KSALEVVETI YTKAKKENND
     NQVIKAFLHK AKYMLTLEEN AQLTIIKNLK NDIENSEFPK RNILESVLAN LYWQYFQQNR
     WKFYNRTQTS EKVDIEDFRT WDLETLFAET HLYYQKSLKN GVLAQQTNLS TFDQILQTAT
     DSKKYRPTLY DFLAHNALDF YKTSETNITK PSYAFTINDK KYLQEQTVFS SLKIETKDSL
     SLQFNALKLF QDLIKFHARD KAPDALTEVN IERIKFVSEN AVFGDKKTVL LECLQSEKKK
     FATHSVSALY DYQIANLYKE YADTYIPEEN ETHRWKLKEA LEICDATIKK FPDSRGANQC
     KALKSQILHT ELNIKTEKYV PIQKPGRLLI TYKNLNKLYF NAFRITPKQL KDLNKLYKTQ
     DQIKFLSALK AAKTWEAEIC DEQDYQTHTT EVLLPELEQD SYLILATISK DLSQKSLFSY
     GNTQVSNLAL IENRTPQKSI FQVLDRNNGA PIANAKIHLK TNNQRGYGNK LDKTLITDSK
     GQAYLTVNTY HYDVSITVSY EKDVARFEGY YLNQSYKPDY STQTNTTTFL FTDRSIYRPG
     QTVYFKGIMM SSDGKEEFKV LPNQSTFATL KDVNGQDVKT LHFRTNDYGS FSGEFIVPSS
     GLTGVYTIQT NNYNSTSFSV EEYKRPKFET KFNPVTETYK VNDEIKLTGV ATAYAGSAIT
     DAKVVYRVHR KVQYPRWCYW YPRHTVEPQE ITHGETVTDE KGEYTINFKA LPDLRVSKED
     LPIFNYEVTA DVIDINGETR STTTIVNVGY HAVTAAITIK DKIDKTQKDN ALTITTINLN
     NEAVAAKGTI KIYKLKAPKK PMRIRPWKAP DYEGFKEEKF AELFPHDAFK NEHDYRKWDK
     GNMVLDKPFN TASTKENETG TQQLSLGSIK KWESGKYVIE LNTKDRFDQE VKDIQYITLY
     SQEDKNISDQ QLFEIITNKS SYKIGDEAIV KFSSASEDIT ITVDIEKNHN IIETKLIKLS
     KNSKTIKIPV TKEDLGGFSI GYSYLNYNGY QSGAMIIPVP YEPTELSIET KTFRDKLLPG
     QQETWSFTIK GPKGDKVSAE LLASMYDASL DQFRPHQWYF DPINRPIYYT QSKRHATQSF
     GVLTFRLQNH NNPSYHYSSQ GYDQLNWYGL YFGQQYFGRN RNYDIMESGA PAPMMKRSAA
     KSAVANEVAM EEAEFNADDG VAGVAGVAGD AAEKDKEESK AEKPQDQQSL EGVKIRKNLQ
     ETAFFFPQLT TDAEGNVSFN FTAPEALTKW KLQLLSHTKG LNAATSTLET VTQKELMILP
     NPPRFLREGD RIVLSSKISN LATKDLNGIV ELQLFDALTN KTIDTKLQNN NARQDFMVKA
     KGNTNVSWEL QIPDDVQTVQ YKIIAKAGDF SDGEQNVLPV LSNRMLVTET LPMWIRSDQT
     KTFTLDKLKD NTSSTLKHHK LTLEMTSNPA WYAVQALPYL MEYPYECAEQ TFSRYYANTL
     ASHIANSNPR IQEVFNQWKS SDALLSNLEK NQELKSLMIQ ETPWLRDAQS ETEQKKRIAL
     LFDLNKMNNE LQSALNKLKQ MQYGSGGFPW FQGGRENRFI TQHIVTGFGH LKKLGVTQYD
     GDTSTMLQNA VRFLDAEFVK EYEELKRYCE KNKIDINKNH LSYTQIHYLY MRSFFTNIKR
     PKNTNEAWSY YLGQSKKYWL NQSLYAQGML ALITHRNDDN TTANKIIRSL DEKSISSEEL
     GMYWKSNTAS WFWYQAPIET QSLMIEVFSE VEAEPKRTEI VDNLKIWLLK NKQTNRWKTT
     KATSDAVYAL LLQGSDWLSV TDMVDIVLGD QKIDPGKIED VKVEAGTGYF KTSWNGNEIK
     PNMATAKISK KGKGIAWGAL YWQYFEELDK ITSAKTPLSL KKKLFLKKNT DTGEEITEIT
     SKTKLELGDL IRVRIELRSD RAMEFVHMKD MRASGLEPIN VISQYKWQDG LGYYESTKDA
     STNFFFDYLP KGVYVFEYDL RVNNKGDFSN GITTIQSMYA PEFSSHSEGI RVTIK
//