ID A0A023DFQ1_9BACI Unreviewed; 300 AA.
AC A0A023DFQ1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00018123, ECO:0000256|RuleBase:RU361159};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
GN Name=rocF {ECO:0000313|EMBL:GAJ39846.1};
GN ORFNames=GCA01S_029_00240 {ECO:0000313|EMBL:GAJ39846.1};
OS Parageobacillus caldoxylosilyticus NBRC 107762.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Parageobacillus.
OX NCBI_TaxID=1220594 {ECO:0000313|EMBL:GAJ39846.1, ECO:0000313|Proteomes:UP000023561};
RN [1] {ECO:0000313|EMBL:GAJ39846.1, ECO:0000313|Proteomes:UP000023561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 107762 {ECO:0000313|EMBL:GAJ39846.1,
RC ECO:0000313|Proteomes:UP000023561};
RA Hosoyama A., Hosoyama Y., Katano-Makiyama Y., Tsuchikane K., Ohji S.,
RA Ichikawa N., Yamazoe A., Fujita N.;
RT "Whole genome shotgun sequence of Geobacillus caldoxylosilyticus NBRC
RT 107762.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227,
CC ECO:0000256|RuleBase:RU361159};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361159};
CC Note=Binds 2 manganese ions per subunit.
CC {ECO:0000256|RuleBase:RU361159};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742, ECO:0000256|RuleBase:RU003684}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAJ39846.1}.
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DR EMBL; BAWO01000029; GAJ39846.1; -; Genomic_DNA.
DR RefSeq; WP_042409155.1; NZ_BAWO01000029.1.
DR AlphaFoldDB; A0A023DFQ1; -.
DR OrthoDB; 9789727at2; -.
DR UniPathway; UPA00158; UER00270.
DR Proteomes; UP000023561; Unassembled WGS sequence.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd09989; Arginase; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR NCBIfam; TIGR01229; rocF_arginase; 1.
DR PANTHER; PTHR43782; ARGINASE; 1.
DR PANTHER; PTHR43782:SF3; ARGINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR PIRSF; PIRSF036979; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS01053; ARGINASE_1; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503,
KW ECO:0000256|RuleBase:RU361159};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003684};
KW Manganese {ECO:0000256|RuleBase:RU361159};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361159};
KW Reference proteome {ECO:0000313|Proteomes:UP000023561}.
SQ SEQUENCE 300 AA; 32466 MW; 0E8099234AA2B6F8 CRC64;
MKKISIIGVP MDLGQTRRGV DMGPSAMRYA GVVERLERLH YDIEDLGDIS IGRAERPDDE
GLRLNLRNLK AVAEANEKLA TVVDDVIKRG RFPLVLGGDH SIAIGTLAGV AKHYKNLGVI
WYDAHGDLNT AETSPSGNIH GMPLAASLGL GHPALTHIGG YSPKVKPENI VLIGVRSLDE
DEKRLIREKG IKIYTMHEVD RLGMTTVMEE TIAYLKGRTD GVHLSLDLDG LDPHDAPGVG
TPVIGGLTYR ESHLAMEMLA EAQLITSAEF VEVNPILDER NKTASVAVGL MGSLFGEKLV
//
