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Database: UniProt
Entry: A0A023DK18_9BACI
LinkDB: A0A023DK18_9BACI
Original site: A0A023DK18_9BACI 
ID   A0A023DK18_9BACI        Unreviewed;       227 AA.
AC   A0A023DK18;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Deoxyadenosine/deoxycytidine kinase {ECO:0000313|EMBL:GAJ41607.1};
GN   Name=dck {ECO:0000313|EMBL:GAJ41607.1};
GN   ORFNames=GCA01S_079_00070 {ECO:0000313|EMBL:GAJ41607.1};
OS   Parageobacillus caldoxylosilyticus NBRC 107762.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Parageobacillus.
OX   NCBI_TaxID=1220594 {ECO:0000313|EMBL:GAJ41607.1, ECO:0000313|Proteomes:UP000023561};
RN   [1] {ECO:0000313|EMBL:GAJ41607.1, ECO:0000313|Proteomes:UP000023561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 107762 {ECO:0000313|EMBL:GAJ41607.1,
RC   ECO:0000313|Proteomes:UP000023561};
RA   Hosoyama A., Hosoyama Y., Katano-Makiyama Y., Tsuchikane K., Ohji S.,
RA   Ichikawa N., Yamazoe A., Fujita N.;
RT   "Whole genome shotgun sequence of Geobacillus caldoxylosilyticus NBRC
RT   107762.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
CC       {ECO:0000256|ARBA:ARBA00007420}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAJ41607.1}.
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DR   EMBL; BAWO01000079; GAJ41607.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A023DK18; -.
DR   Proteomes; UP000023561; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01673; dNK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000313|EMBL:GAJ41607.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023561};
KW   Transferase {ECO:0000313|EMBL:GAJ41607.1}.
FT   DOMAIN          16..215
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   ACT_SITE        91
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         20..28
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         44
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         56
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         67
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         92
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         97
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT   BINDING         151..155
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT   BINDING         160
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
SQ   SEQUENCE   227 AA;  27221 MW;  4E4B46CF50A9B8B2 CRC64;
     MMNLREKYYI PDHAVITIAG TVGIGKSTMT KALAKALNFR TSLEKVDTNP YLEKFYDDFE
     RWSFHLQIYF LAERFKEQKR MFEYGGGFVQ DRSIYEDAQI FAKMHFENGT MTAVDYETYT
     SLFEAMVMTP YFPHPDLLIY LEGNFDEVMK RIRERGRPME QKTPVSYWKE MYERYEAWIN
     KFNVCPVLRI NINEYDIIED ERSIEPIIQK AAAIIREYEH IKNNRLR
//
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