ID   A0A023X7Y1_9ACTN        Unreviewed;       502 AA.
AC   A0A023X7Y1;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   ORFNames=RradSPS_3043 {ECO:0000313|EMBL:AHY48326.1};
OS   Rubrobacter radiotolerans.
OG   Plasmid 2 {ECO:0000313|EMBL:AHY48326.1}.
OC   Bacteria; Actinomycetota; Rubrobacteria; Rubrobacterales; Rubrobacteraceae;
OC   Rubrobacter.
OX   NCBI_TaxID=42256 {ECO:0000313|EMBL:AHY48326.1, ECO:0000313|Proteomes:UP000025229};
RN   [1] {ECO:0000313|EMBL:AHY48326.1, ECO:0000313|Proteomes:UP000025229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSPS-4 {ECO:0000313|EMBL:AHY48326.1,
RC   ECO:0000313|Proteomes:UP000025229};
RC   PLASMID=2 {ECO:0000313|EMBL:AHY48326.1,
RC   ECO:0000313|Proteomes:UP000025229};
RA   Egas C.C., Barroso C.C., Froufe H.J.C., Pacheco J.J., Albuquerque L.L.,
RA   da Costa M.M.S.;
RT   "Complete genome sequence of the Radio-Resistant Rubrobacter radiotolerans
RT   RSPS-4.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP007516; AHY48326.1; -; Genomic_DNA.
DR   RefSeq; WP_041339101.1; NZ_CP007516.1.
DR   AlphaFoldDB; A0A023X7Y1; -.
DR   KEGG; rrd:RradSPS_3043; -.
DR   PATRIC; fig|42256.3.peg.3091; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_10_11; -.
DR   OrthoDB; 3802174at2; -.
DR   Proteomes; UP000025229; Plasmid 2.
DR   GO; GO:0018478; F:malonate-semialdehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AHY48326.1}; Plasmid {ECO:0000313|EMBL:AHY48326.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025229}.
FT   DOMAIN          16..478
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   502 AA;  54235 MW;  40583944FC69233B CRC64;
     MHKTKREVRN FVGGEWVEAN GRKTEAVYNP ATGEVIAKTP LSTKEDVERA VGAAEAAFSG
     WSATPVTQRA RVLFRFKMLL EEHFEELRDL VTLENGKDAK DAAGEVRRGI EVVEFACGMP
     SLMMGETVRD VASGIDNVSW RYPLGVVAAI VPFNFPCMIP LWTMPVAVGA GNTYLLKPSE
     RTPLCSKRLV ELFVEAGVPE GVVNLVNGAH ETVNAILEHP RVKAVSFVGS QPVAEHVYKT
     GTASGKRVQA LAGAKNSMIV LPDAVLEKAV PNIVSSAYGN AGERCLAGSV LVAVGEKEAQ
     DRVVEKVREA ASSMKVGAGY EEGSELTPLI RDSHRQKVRS YVDLGEKEGA EVVLDGREVR
     REEGFFFGPT ILDGVTGEMR VAREEIFGPV LSVVRVDTLE EAVAFTNGSP FGNACSIYTE
     NGAAVRYWRE HVEAGMLGVN IGVAAPMAFF PFNGVKNSFY GDLHATGKDG VRFFTENKVE
     VVRYLSEPAS GEAVRLPQEA GA
//