ID A0A024B0T2_9CAUD Unreviewed; 300 AA.
AC A0A024B0T2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS Bacillus phage Hakuna.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Bastillevirinae; Wphvirus; Wphvirus hakuna.
OX NCBI_TaxID=1486659 {ECO:0000313|EMBL:AHZ10075.1, ECO:0000313|Proteomes:UP000026900};
RN [1] {ECO:0000313|Proteomes:UP000026900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sauder A.B., McKenzie Q.R., Temple L.M., Alexis B.K., Al-Atrache Z.,
RA Lewis L.O., Loesser-Casey K.E., Mitchell K.J.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KJ489399; AHZ10075.1; -; Genomic_DNA.
DR RefSeq; YP_009036506.1; NC_024213.1.
DR GeneID; 19526057; -.
DR KEGG; vg:19526057; -.
DR Proteomes; UP000026900; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..295
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 300 AA; 34876 MW; 3B794B70DE44FAEB CRC64;
MTTLQQIREN DVDYLTNAMF KDVLTHGERR EDRTGTGTIS LFNVNHTFDC SNKFPVVTNK
KVPLRVVFEE LMWFLSGSTD LKWLLDRNVH IWDADAHRFY QEQGGELDFD SFIEMASIYG
FDLGPIYGKQ WTDWNSEGFN QIEWVIEEIK RNPESRRLYI SAWHPTAFKK AALPCCHVSF
QFYVSNKDTL NLKFSMRSND LFLGYAFNVS SYGYLLFLVA AMTGLKVGSL TYDAGDAHIY
LNHLKQVELQ ISRKPFPQPQ LIVNGVKEKI TDYKWEDMEF TEYQHHETIK GKVSVGEVKS
//
