ID A0A024FD06_9FLAO Unreviewed; 271 AA.
AC A0A024FD06;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN ORFNames=WPG_0362 {ECO:0000313|EMBL:BAO74592.1};
OS Winogradskyella sp. PG-2.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Winogradskyella.
OX NCBI_TaxID=754409 {ECO:0000313|EMBL:BAO74592.1, ECO:0000313|Proteomes:UP000031636};
RN [1] {ECO:0000313|EMBL:BAO74592.1, ECO:0000313|Proteomes:UP000031636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG-2 {ECO:0000313|EMBL:BAO74592.1,
RC ECO:0000313|Proteomes:UP000031636};
RX PubMed=24874677; DOI=10.1128/genomeA.00490-14;
RA Kumagai Y., Yoshizawa S., Oshima K., Hattori M., Iwasaki W., Kogure K.;
RT "Complete Genome Sequence of Winogradskyella sp. Strain PG-2, a
RT Proteorhodopsin-Containing Marine Flavobacterium.";
RL Genome Announc. 2:e00490-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001419};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008847}.
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DR EMBL; AP014583; BAO74592.1; -; Genomic_DNA.
DR RefSeq; WP_045468598.1; NZ_AP014583.1.
DR AlphaFoldDB; A0A024FD06; -.
DR STRING; 754409.WPG_0362; -.
DR KEGG; win:WPG_0362; -.
DR HOGENOM; CLU_060704_1_0_10; -.
DR OrthoDB; 9808470at2; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000031636; Chromosome.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02127; pyrF_sub2; 1.
DR PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000031636}.
FT DOMAIN 16..254
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 271 AA; 30199 MW; 4BF2D1C1142972CE CRC64;
MTTTQLVSQI QRKKSFLCIG LDVDLNKIPS HLLEEDDPIF AFNKTIIDAT HHLCVAYKPN
TAFYEAYGLK GWRALEKTIN YLNENHPDIY TIADAKRGDI GNTSSMYAKA FFDDLGFDSV
TVAPYMGKDS VEPFLAFEDK HTILLALTSN LGAFDFQTKN VEGVELYKQV LETSKSWRNS
ENLMYVVGAT KAEFLGDIRK IIPNSFLLVP GVGAQGGNLH EVCKYGMNDS VGLLINSSRG
IIYASQEDDF AQAAAKNARE LQMQMDEILS K
//