ID A0A024FXJ7_9STRA Unreviewed; 2588 AA.
AC A0A024FXJ7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
GN ORFNames=BN9_000710 {ECO:0000313|EMBL:CCI39288.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI39288.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI39288.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI39288.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the SKN1/KRE6 family.
CC {ECO:0000256|ARBA:ARBA00010962}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI39288.1}.
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DR EMBL; CAIX01000001; CCI39288.1; -; Genomic_DNA.
DR STRING; 65357.A0A024FXJ7; -.
DR InParanoid; A0A024FXJ7; -.
DR OrthoDB; 49412at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR000757; GH16.
DR InterPro; IPR003440; Glyco_trans_48.
DR InterPro; IPR005629; Skn1/Kre6/Sbg1.
DR PANTHER; PTHR12741:SF29; 1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 2.
DR Pfam; PF03935; SKN1_KRE6_Sbg1; 1.
DR SMART; SM01205; FKS1_dom1; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51762; GH16_2; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2588
FT /note="1,3-beta-glucan synthase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001529139"
FT TRANSMEM 443..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1065..1086
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1169..1189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1195..1214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2070..2096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2108..2133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2145..2166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2198..2219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2226..2247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2296..2319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2331..2352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2364..2384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2396..2414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2426..2444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..408
FT /note="GH16"
FT /evidence="ECO:0000259|PROSITE:PS51762"
FT REGION 2553..2588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2553..2568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2569..2588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2588 AA; 293867 MW; BC1A725B59E05651 CRC64;
MVVLGVLLAL LPTLCAFPHV KTSIHNNSQW IDPCTPKDQY TKDIPNGNHS IYTGTNTTYR
LIFSDEFNVS NRIFESGYDS KWTAIDHRDV TNMGQHYFLP QAVQVDKGNL VITSSKPKKR
YKGARYVSGS VQTWNKFCFT GGFVEVRAIL PGKWGIPGTW PAIWLMGNLG RATYLGSQAG
TWPWSFDACS WWVENGEKIH QKINACGNKT DKHVKNSYPE NYGLNPFQGR GSTEIDIMEA
QIKLRDTPAF ISTSLQIRPA LFPNRRPASE TLPGPGQWYE DLKFGNFTRI NSDYYGEMGL
DSISAVTQLE SNSFNSFHLY QLDWMPGPHG YLRWWLDNVF VFEIPGEALN QWVDGIPPRQ
IPVEPSYIIL STAVSEKFSP PCEGQICDSI WPSNFTIDYV RVYQGPVNEY TSIGCDPELF
PSQEWIHLHP VEYGLPWYAS LNVVYGLTSL FAAITLLMSL FVMIWGSKFS SWVTFYSATL
FLAVSCHAIF SVEELEQFAW IHTTLACLCG VVFGALAAII PVGALGAMSG FYVGILSGPF
VNVTIVRIIC GIFFFVGFLI EFVPLIADLS LIVTTSFLGA LNLIASASYW FGDDKYWRYL
LQMTGHILGG VGYSTVDMHT KDCYILYSAL MISFTGAVVF HCITSRQLRR LGYNEPGKNN
DLNGKKDGSI HSISASSAAR SWRPDDTSVE RANFFAPSEL PAHMQPYSTV FNHAVSVQKH
FGFQTDNLRN QTEHLVMLLT NCSRNGQNSY RVVHDRMFSN YKKWCHKLKI PCNNWTIDTT
SPSEWTALDE MNIDLCLYLF IWGEASNLRH CPEYLCFLYH KMKAEYCSNR SSRRDPGHFL
DTVITPVYLL LKTQLSSNYD HQYRQNYDDF NEFFWQKECL NYDYKYEKVN EVFSPNSALL
FGGSNSFGHD KTSGRPSGPY DGPHQMGIAH APSFRGGNLS VAEAIAAHPK TFLEKRTWLA
SLRAFYRIFA FKVVTFHFLA ALAFGIEMEH PIHTIVRLCS SALIMRFFLS IIKSGMDVVA
IYNPVTGVRP LLRDVVWTVY YLIITVVTLA LYWNAWSKDG TSWTLYYVVA TTFHLPGIMN
AILQVIPDAN NWIRRTQCKP VASIRDFLNP MNRLYVGDNV LDPAHLSIGY QMYWLTLVIW
KLIFSYQFEI RPLVVPSYLL YRDQIEYDVS AVTTAFLIAI QWFPFFLVYC VDLTIWSSLW
AACTGTFVGF ASHIGEIRSF HRLRAAFGRA ADAFNSKLIA SKSKTGQKIT ESMSNVYGSV
GNEVLDQISD TASSSSQYYK TSSASDETPL LSFSRRKQTA DEVKLRRRQK WFSFSVAWDS
IIESMRADDL ICNQEKTLLR FQRVEGYQRE IYLPQFQLAG CFEVFNSKLS DIFASDNNVT
ERALQDKMLQ ILCQHPMIEE ALEEIWELTH WVLVNVLGPC HSNDVRHITS TLSLWAQRGL
FRAMDLRKVD DCGHALTDLL LLIMGNLGSW KSNAKYIPVR KSPAEYSSYQ FPAASLGLTT
RVSVGMTKSA STTGLSSLGG TVPRRSRGSG VARIAAMQHL AKSKDAKSKG DHVIPSAHIM
QVRDKLRLFL NVFKNMLTHL PETDPLFIES RGISDRLTWI LTQERGFMWD DDYTGEQITL
LTFERHSSTI LQHLHALLTL QKIDAEPRSY DARRRLLFFV NSLFMDMPLA PLLAEAKSWS
VITPFYGEDV LYSRKDLESK RDGLDVHTLL FLQTLYKRDW ENFLERVKPQ KNWWKDPQTA
MELRLWASLR GQTLCRTVQG LMYGEAAIRL LAEIEQVPVQ HIEDLVKTKF TYVVACQIYG
RQKRNNDPKA RDIEFLLQRF PNLRVAYIDE IRVNYQREQS YFAVLIKGGH ELGCVEEVYR
VRLPGNPILG EGKPENQNSA VIFTRGENLQ TIDMNQDGYI EEALKMRNML QEFDSGLPER
PYTIVGLPEH IFTGSVSSLA NYMALQETSF VTLGQRTLAQ PLRMRLHYGH PDVFDKLFFM
SRGGISKASK GVNLSEDIFA GYNNCLRGGS VKFPEYIKCG KGRDVGMQQI YKFEAKLAQG
AAEQSLSRDV YRISQRLDFF KLLTFYYNNV GFYISVSLVI WTVFIMLYCT LIRALLSLEG
TGGRSTVILS NLQVSLGAVA FFTTAPLVAT ISVERGFKAA AQEIFMMFIT GGPLYFVFHI
GTKWFYFGQT ILAGGAKYRA TGRGFVTKHS HFDELYRFYA SSHLYAGVEI MFGLILYYLH
TESTQYIAMT WSLWLVVLSW TFSPFWFNPL AFEWSDAVED FRVWFKWMRG DGGNANQSWE
AWFKEENAYF STLRPFAKVC VTLKGLLFTV VALSIAPSGD PYHSLLKMKT WLPFLVCFSV
ASVYVVISSW FLNAKKYGES GLLRFMKSLL VLLTVLILII AFFLVPGMLA CVLSTYYLGA
AIGCWALLIL GSNARLVQNL YFVHDAILGL LSLSMILIFA GLYVPGKIQT WLLYNNALSR
GVVIEDILRA SSRHEDREDE LSLHQMRSII MEQQRVISAL AGNGTDSDSS LAQAHGDLVH
TMSDNALSAM RNMSESDLAA IHDASRRLQA IVQHDSEPPK RNEVNSEPHI RRSLSTLNDQ
MRPAVDSS
//
