ID A0A024G4P1_9STRA Unreviewed; 2265 AA.
AC A0A024G4P1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN ORFNames=BN9_025980 {ECO:0000313|EMBL:CCI41814.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI41814.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI41814.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI41814.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI41814.1}.
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DR EMBL; CAIX01000025; CCI41814.1; -; Genomic_DNA.
DR STRING; 65357.A0A024G4P1; -.
DR InParanoid; A0A024G4P1; -.
DR OrthoDB; 1705390at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:1901137; P:carbohydrate derivative biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR005855; GFAT.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035490; GlmS/FrlB_SIS.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR01135; glmS; 1.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF0; GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); 1.
DR Pfam; PF16113; ECH_2; 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 5.
DR PROSITE; PS51464; SIS; 2.
PE 4: Predicted;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 127..357
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 432..573
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 606..752
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT REPEAT 1895..1933
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1934..1972
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1973..2011
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 2012..2050
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 2088..2126
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 2265 AA; 250648 MW; 6B7BE524E72AE5C4 CRC64;
MLLHGKKNSG ATLQGLNFHA LLGKSTDMIR QFSRRSPTRL VFDIKAIPLH YSLVYESSIL
HHRRHIETSY GTIAKVGAKT TTTSVTKTHH AIIGLLLAAG ISLQYGDRKK NGEEYEVSLF
GKIAECCGIM GVVGKSGNAS NFLLEGVTIL QNRGYDSAGM STQKSIPDEN GQAPITTTKF
ASVDGTADSI QLLKNSKEQH DGNNVGIAHT RWATHGSKTD HNAHPHMDMH GRVSVIHNGT
FTNYNEIKQE LTSEGVIFAS DTDTEVAAQL IGHLMGDGAD VLTATRLALS RLEGTWGLCI
MARDEPGKII VARNGSPLCI GYGSNEMYVA SETTAFSRYT KRFISLKDGE LAVLKSDSAE
LDPVDEKEGF LQRFPTSRYA TAPDVKVRLA PTPYPHWTIR EIMEQPKAVA AALGYGGRVS
VDHVYLGGLE AEKERMLKIK NLLIAACGTS LYASKYGAKL MRSLNAFDNV SAEDASECTP
DRLPRKKAGV LVVSQSGETL DAVRVLKMVE DLPVEFPTFS VVNAVGSLIA RTTKCGVYLN
AGRENAVAST KAFVTQVTVM GLIACWFAQN RPEGNHTKMD ELIQSMHRLP IAIGIALRTR
QQCEQVAEKL MSSEHLFVLG RGYGEPIAYE GALKIKELSY LHAEGYPGGA LKHGPFALIE
DAKDGKNGAT PIILIVLDDE HAQYMKTAAQ EVRARGAHTI VITDNAKMCE GIADTIISIP
TNGPMTALLA SVPLQLIAYT LAVKKGINPD VPRNLAKAQD AGLRIVKLNR PEALNALSFP
MIDHLYGRFK KFEKNWTINA VILSGMGERA FCAGGDIRAL YEQGKNEATR HLGKNFFRRE
YELNYFLATT EMPIISFLNG ITMGGGAGIS MHGKFVVATE KTVFAMPETA IGFFPDVGSS
YLLPRLGRRL VEGEHYRADV GKSAAMEGQG LGTFLALTGE RLKGPEVIGF GLATHYMESN
VYDNLMHHLT GFDFPNDMPQ EERDEALHEA LEEFETEDAQ QDIDSEYLQT VESIFGAKNS
DDTMEGIFSR LKSHNSEWSK TTLATLQKMS PLSLKVTLEL MREGAQKSCE DCFQMEYRIA
SRMLTKSDMM EGIRSMIIDK DRNPKWTHGS VDDVKREDVL GYFNALENEE ELVLGVSADE
NANISKDDPV SNTDVSEKLN AKSSALVHSE CTARTEKHVY VPADEDTVSI ITPTSKEHSF
RISRNLTFQQ LLIDAASYWS LPTSQVVLRD GKGGIWPHSE SVMVTLAAKR NRKIKVILDI
RQTSWASTFA HLEEACNSKR DQIEPFPKSL PISNASSTLY KDLWGIFTFY CVQGGDLQVD
LMKAHQFTKL LQDCQLLNKV VKLEIMSIIY NGEINGKVQL NFEEFLNLIS RIAKLAITKK
LKCIQGCKKE EEAVYQLVVD HILPKACRWP QEEWEVSTIK IHQREVIVFF FGHLKALLAI
FIFYARSYHK NPATGMREFY MSYQNFQRFI NDFLFAKLQL STVSCAQIFL AACCSCPFHV
PIYHTVDKDT KVLDPESSSI KAFVATKDVE ETRIATIRDL ISTSGVVVAY TFPASLENRA
TCMGFSAFID FLGRASLTAY TKSDTISCVK ALIHHVCSEA THARVMEIIE NHGSSCVHAN
TFYMGTAALK SKFFKAWKEE GFPDYLAANV DVARRPERAV HRKARLLHQR AAMGKNLAIS
SFQYDSAVSI KASGSVEEEE IHPLKLLMED MSSDEPETRI KSMRKLKTVA QALGHDRTRC
ELIPFLRDST DNDDEILVAL AEEVGDFVDL VGGPAHAAIL VDPLEVLAGI EETVVRDRAV
QSLQKVIKAV PNVGEVMVPL LRRLVEGDWF TSRVSACSLF APIYSRLVDV GQKKQVRELF
SVACSDETPM VRRAAASNIG KVAANVEQEF VVTLIVQLFK TLTSDDQDSV RLLAIENCAA
IAELLSPEEN QQHILPVVKT SAEDRSWRVR YSIAKDLFPL SRAMGSQITE SELLHCFTTL
LQDTEAEVRA ASAKNIPGYI TIVKYDLFNN EVIPLLSNLA QDTAPNVRTA VSISCMELAP
KLGEAAAKTS LSPMLLLFLR DEVVDVRLNI LKRMENLAPW MSSFEDVFLP AIADLARDLQ
WRVREAVVLS IPSLVGSLGT QYFQEHLLDI YLNAYSDMVG EVRLSATKIL PQLVNTAGNE
FMLQHVLPRL TAILEKSIIY QERVNVLHAL EQLASESASG ELLNGSITLA IRGAQDKIPN
VRFVASKTLK ELSKHTDATV IATQVRPCLM ELLNDADTDV NIILQ
//
