ID A0A024GER1_9STRA Unreviewed; 1747 AA.
AC A0A024GER1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=BN9_062270 {ECO:0000313|EMBL:CCI45354.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI45354.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI45354.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI45354.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI45354.1}.
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DR EMBL; CAIX01000095; CCI45354.1; -; Genomic_DNA.
DR STRING; 65357.A0A024GER1; -.
DR InParanoid; A0A024GER1; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05534; POLBc_zeta; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 747..981
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 1109..1580
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 460..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1747 AA; 198745 MW; 82299998E94EA7C4 CRC64;
MSSVVERTND EEFIRVDVVH VDYYMNTPLP DNELFNLPKS PYYRKAHRVP VIRIFGSTSA
GQKTLVHLHG VLPYFYLRCE NDPIFEKLSE LQKLLPALAT DIEKSFQKKL DHSSTISSNA
KFSNVIAKLM IVKGIPFYGY HDQPCLFIQL FYYNPRHSNH LVHMLESGQI VKRVFQTFES
HVPYMLQMFA DYHIEGMNPL YLSNVKFRAP LPVSQHHLMD DMSAIVDTRE MCRRIYLQGN
VPEHMISSSS KQISVGIRGR HVPVTDFPQS NGCRQSSCSL ELDVAIASVL NSRRFREHQI
SLETRGIVNN VPSLAVLWEE EKERRRMAHL DESPELPDSY PRETDTQQKR FFGSRSKTDV
RLSQTLLSQS HFYDQMKTSL NKIMTKIINV KSEGIEEKRG HSEVEGDDLV PMSSQIHSPD
TENQFSFSQN CCGMSDTKRA EEDLDILNFL LKMKNPLEDS STGVELENEV ADYRSDRSDE
SDKRNDAAEA TAILESQRVS TSESPNHKSN ATANRPSKWW EVSTDKSQHA ADIGSSRINR
ASDRTKKLQK QDFFSLNAKS CSRKAQLTTD SQASETITYS REVWAADTNR IKTDCTQSQC
IKSSQEMIHQ SNTNNRLKAT PDTSPILCLS KQRKRRKASI KRDSVQENKV WLYRARPPTF
EELIESSQSL GILPHHNTGA FYSDPGDLPK KPLKFGGYKF QFTDQNDVTK LDRFDTSLQR
HELSSNTIGR VFRGLDELIS VEQGEHKRSG YRDANHNRLY TTAMLPPSQS MVRNWLSKEA
SSRQNEVKRE ALSTSNQINS STSLSATEQV HSTSTPNITT LSVEVCAFCR GSLSPDPAID
AIGAIAYAIS AKEGFHRNKT KHTGVIINTA EDKAIPDSQN TLVKESQDTL RFDANFAQLI
TAKRKLIGKR FCLGRHDAAV FAVSSEEEIF TCFNKVVETW DPDFLTGFEV QKSSIGYLVD
RAMHLNINLI QTMSRLPQTP IDARNPVSHV NVDDKDPGKI KTSIGTIWGM AKASGLWIHG
RHVINLWRVA RSELKLARYS IEDIVQSVLQ QTWPTYSWQE MSTSFREEGL RRWKMLDHLL
DKAVVNLKLL SRMQFITRTS EMARLFGIDF YSVLSRGSQF RVEAVMLRVT KRNNFVLLSP
SRNQVAAQAP MECIPLVMEP QSRYYSDPVV VLDFQSLYPS LVIAYNLCYS TYLGRLENGM
KPELETFMGV TSFSPDEKGF TNCDQEIHIA PNGTLFCPKS RRRGIVPAIL EEILATRIMI
KHAMKKHQSP TLSKNLYKKL DARQLALKLI ANVTYGYTAA GFSGRMPCAQ LADAIVQTGR
CTLEATVRVV ESHSEWNARV VYGDTDSLFV LLEGRSKNEA FCIGQEIAKK ITALNPRSEN
LFDIRMWQCS SLVCRPVELK MEKVYFGCIL VSKKRYVGYK YESLDQVQGE LDAKGVEIVR
RDSCVLVQKL MRTSLQLLFE TRDLSRIKRV MIHLRRQMLS NQIPLRDYVF AKEVRLGSYA
DNSHAPPAAL VSLKAMASDP RAEPRYAERV PYVVINGFPG ARLIDLVISP YRFVANPSGN
TINYQYYIEK QIIPSLERLF LLVGVNIRDW FASVSKVNSK ANGYASIDIE DLLQEKPQHP
RRYTPSNRKS IEFFYKSVRC YLCGSVIPSS SMISLDWIRT NALCPCCQEN AQRSLLQLKH
GEVLLDMQLG KLRQLCSLCT EGNQFIWYQT CQSLPCPIWN QSQILGDRVG RIISKSPEEE
KESLVGL
//
