ID A0A024GTW0_9STRA Unreviewed; 3595 AA.
AC A0A024GTW0;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=PH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BN9_117120 {ECO:0000313|EMBL:CCI50165.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI50165.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI50165.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI50165.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI50165.1}.
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DR EMBL; CAIX01000406; CCI50165.1; -; Genomic_DNA.
DR InParanoid; A0A024GTW0; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3454..3474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2170..2586
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3312..3466
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2923..2947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2933..2947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3595 AA; 408507 MW; F47EDD08F503356B CRC64;
MQSTLSRLKE MGSSRPDHVD GQWSSTTFFE WWNFEENARL HRFVLAPFSA SLKLEINFAN
SSSTNADPRY TAMFYLSRLN CAIDEKQLSI WGLIMDSFNT HDEWRHDMKM QLIAEERRAL
YTNRDATQHI ENEYLVSWDK ILSAKIAQLE HFHHIEKSNA WRELLQLERD LPLSYIVYLR
NYGSYEDVMK KACFSEKKSR PDNGPRDVTY RDTPEDTPIE VHMQFPRGST GLVLTYHRLT
QELIVIASKE DTAASENRIR PRSRLIKLNG ESILEKAPSQ SGIDYQKWLD ELDLDIKILS
FHLPPEEHAE DVPLNVVSRV KFHTTKLKFT IVSAARTIPI IRCVLYDAAL SMIGLGDSLF
SYHQYDIAIG SFLLQNMIVR HGFWHQEEPL VSYCILSSVR RTQRDLGNYL QDAEKEANRS
CSLHLGADFL YKQHQDVKKG SYGVKYLIHL GDIVAVFDED KITQLVSALY SFQYGILAPE
KTRSTHTTGD KKDDTEHCDH RCSHGKDGGS TCLSSVSTMD SSNRTYDEAG FSNLKVEQPK
PETRKLIRTT FDVQLGHIRM YICGKDIESS EDDLDARTNH DACSSSHSFD CTEHETQAAL
VSREASYWNV LHQLAPNDDH ESKADGGTRS SDLNMFPRDW IQYNEAVVNV QRHIRGFLAR
KLPIPRMVLK AHSSVRRIDY AKFGWLYKRD DTLTFCRWQR YWCYMNSEGD FFVYNNGSGA
GLVTRFSVAT CGTTLMRNGR GPWGLPCHLK NSGTPILEIS DANRQILGVF SDKKISVLEE
WKKAIEKMSE HLKDRLAYGS LLASVDFDQV QDRRPAVKED IGPSYQSPFS SIADMMRGYD
YFLESGFSDT YTRSKELQKM HTNWLVLDVI NVTFTCDICN ENIGNHTAFQ SNLTAQSMTL
LDYRRFDIGR PAVFHIGDEF LSFQKNTFLP SRVILNPFFA TKNTYVSVNA TYGSVFRDTD
DFFVGQKRAS LKISLAGWVM PLTILSSIMD ISAALSVLWR ENPSDSYTTG TIKYQTQDNE
RHPNGTESRD TLDRAQSLVP ARITAQTTST APGMDSLAGN ALFQVTELCL QLQAPMIEAY
IEDIDCVVKL TLEKVVCSLR AGSYAEELTI NLGPTALYLL TNEMALRLVQ LNKLYVEYEL
AVWKQAQENW SNGSFAKSSI RKEKRWKSRE EKSKRPLCYR FVDIRIGQIK LEADRRLQLL
FALIEALTLP STNDDMEQSL PWKYEEESHP EHLSLDERHR QSIQSTKSRS GGRSKQVLEP
PSTLFSSILD DENDPFRTGS GLIDSHLLDQ LTYPISGFSR SEHTLRPGFP LSFTKNKDSG
SSPNLRRSFD FSPHFRKRFS FSSNHNAPIS GAHSQAPYER VTNRCDDMLL GPLMSYQTYI
VIIKDKTRCY GGEKCHSMPI RGAPSSSSRK WAHGSPDPGM KSTGKSFLYA LKLRKGRVYD
CIFFHCDAIV LEVIKRSLSI VALDTYIPVM NFALRDINAE ILTNSELSSD YGVSASIGIC
AQYYNNALAD WEPFIEPWRV NALLRKQDDS PNRTTGFEVR PQESPHGIKG RLQPPQCVET
TICLSAMERL NINFTHALVC LLCSVAKNRQ KQVFSIEKRK PAAVAADSEA RKQDGRVCVL
NNLGVPIRLA NLNTSRRGSL FIEIRDGWAF PSYSRFHNIR MEVVLLPWWS PRQGETLEQL
RHVFILPYCG AQSGVTPILR VAVSTAVDEK IMTNAKSFEH DTDPLPDPFS IVNEKDGIEL
RAWGSATALK PSDDSMEHWE AERDLDPLGP KNVEKKYWQL LGVAEVNLAA TVMGYGTSAE
QMRLTRWFRL HDARGAPTGE VLLHLKFIPS DLPESEKSDF EDPKVVKDGQ FLVFDPLKMV
SVGHRTRESC TASSISKTLE TELENGHENQ TEDERNASQL QHVILADSLR GAYIPPLALE
ILLDNKRYNL LCPLRRAGKF LIQCDNLTAE VKVAQRDETR RVLLLNSPVQ LKNETQANAV
FWTKQLDQKA LEAKDLLPEN DQHAIYLKAN SKISVPLSAL HGEKKHSIIM SVNNCTPRVI
ADLDDLNPGT LLLYWSAEND EEHPNSEGLR TETPYRRRNS SLSHSKAFSE NSGIAQLWGY
CFLVTIASHT RKVYREDQQT LPANEGGNMI YRPKQEKLGH PAKFYKGDGD TSHHRGASYA
KWSEVDTQSY ATKHQISLHA CLLFENTLPV RVQYKVVLEK TVQREEIVIR AGTLSPGKSV
RIYEFQKDAV LQLRLPEMDT MWTKPILLAE CIYRESSMRE QERNLLGLPK VAVKPRAVRP
VAVASSAAAA VLTSVQRKIS QHDRVVEFYP KAPSLNMMFE KEEMEAKKVI TRMDFTQSDN
QSPRIVLYAS IWIYNQSHMS TLMFRDANDS TASSTVVYAP QIVPEHPNPK LMDCPSHSFE
MNTRVDHEIA RWSDKLHSAV VGVQDPITFE FGRIDLRRNK KRFEVGVSIE RPLGQFHRTA
KVLVAPRFVF VNQTQVTFKI SQSCRENDSN VVEVEPCYKY FFDSATNTMD PVLAAGSTLS
PSMASASQSA RERAGYEETE HVSGGPLVWT PFDFLYSDSI AQTRKRRVFI KMAHATAQWS
GPFAIDYEKE FPLRLRGGVA SSWSSTRSWT RPNKDKDDPL AKFELALGAF AQYRLRIRIT
AVGATMVITL MKDDPPMFFI RNESTLELHV SQARASESSM MLQSGEYVPF AWDRPEKTTR
VSCRVSSPKT RAFGIEWNRT SVKVPRLFDF ENLDREKGIV ELTRWFYGRS ISGEIKVEKS
SRVLVFKDQV AKKEPEYLME IKILSTKMRT REGPDTLGRF CVQIMQEKRF TEYKERKNSN
LYRFDSELAF SFRSRPKHLK LTLCETSKVN AQLDQLNDQR DVSSISIHDK EDPIRASKHQ
DISAGNMVDL TRFEDDDHRF GLYRSIQTPD QWCRQISNIP NCDSDRPNDL EDDLIQSQSS
SSSEEVDNAS RLLHTNVLGS ACKLGRLKIR IPAKIWAQNH NDQRHFDSIA SIGPNCLSHA
AALSYTCGYD AGQPALNGAF YGAAVSNESN WWALQDSESG DIIGEVQLAL KCRRTFVPAA
SMASDFFNIS VTIPSIGISF LHNSTPNQSM LEVAFLSLQR MSLLYSCVNG QNSEVVFRLG
NLQMDNQMDA EVVVGPKIQK VDRGVSIRLR DRLKACLDYR YRGILSNDIG LLQNSTSFKT
PNNVVHFRML WNAQCVAGDI THYELIQLAI QELEMSTDEK FIVNLIIVFQ GLEILTRQHS
FDEIVDSEIS FVDEKAALAA AYVANLASRG LVNTMLEYEN QKDAMRRRQR DADTEAAAIT
KLASLNPTNQ SIYVEELQID GIRIQFSVEL NGGRYIRTLG SVGRRLATYF PESNVKDLGL
NLPKATFSHI YNSQATIIRS LLYHYRHHAV LVVVRGLHTV SLYANPLRIC YRFLHGIIEL
IRLPLRGLMS GSPIELLNGA YLGVRALVMN LISGGYEIVA GAAGLLTIFV GLILPESKRR
AFEEDMFAFQ RSVMEEVDAF DAQEERAMVK TIVRQPRKFD AGNIGLLTVY GPGALPIEEQ
SQIDYNAAVM IQEWWRRRRL AEKLMEHVRE LNPNFETITE EKTIKTSHWK ECLIL
//
