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Database: UniProt
Entry: A0A024H4T2_9MICC
LinkDB: A0A024H4T2_9MICC
Original site: A0A024H4T2_9MICC 
ID   A0A024H4T2_9MICC        Unreviewed;       535 AA.
AC   A0A024H4T2;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   Name=hsdM {ECO:0000313|EMBL:CCQ47180.1};
GN   ORFNames=ARTSIC4J27_3160 {ECO:0000313|EMBL:CCQ47180.1};
OS   Pseudarthrobacter siccitolerans.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Pseudarthrobacter.
OX   NCBI_TaxID=861266 {ECO:0000313|EMBL:CCQ47180.1, ECO:0000313|Proteomes:UP000035722};
RN   [1] {ECO:0000313|Proteomes:UP000035722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4J27 {ECO:0000313|Proteomes:UP000035722};
RX   PubMed=24948757; DOI=10.1128/genomeA.00526-14;
RA   Manzanera M., Santa-Cruz-Calvo L., Vilchez J.I., Garcia-Fontana C.,
RA   Silva-Castro G.A., Calvo C., Gonzalez-Lopez J.;
RT   "Genome Sequence of Arthrobacter siccitolerans 4J27, a Xeroprotectant-
RT   Producing Desiccation-Tolerant Microorganism.";
RL   Genome Announc. Announc.2:e00526-e00514(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCQ47180.1}.
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DR   EMBL; CAQI01000048; CCQ47180.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A024H4T2; -.
DR   STRING; 861266.ARTSIC4J27_3160; -.
DR   REBASE; 89118; M1.Asi4J27ORF3159P.
DR   Proteomes; UP000035722; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42933:SF3; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:CCQ47180.1};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000313|EMBL:CCQ47180.1}.
FT   DOMAIN          42..169
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          181..495
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   535 AA;  59696 MW;  480E543C1DB03D98 CRC64;
     MTYPRHCGMN WNLVRENVTE DEAREYAGGF HLAVQPLSLS ELESYLARAA DLLRGSIDQA
     DFKAYIFPLM FFKRISDVYM EEFAQALEDS GGDHEYALFA ENHRFSIPGG HLWGDIRNRT
     ENIGTALQTA FREIEKANPE TLYGIFGNAS WTNRDKLPDR KLADLVEHFS TKTLSNAAVA
     PDVFGNAYEY LIKRFADQSN KKAGEYYTPR SVVRLLINIL NPVDQESVYD PACGTGGMLI
     EVIEHVKAAG GSPKSLWGKL YGQEKVLATS GIARMNLLLH GVEDFKIVRE DTLREPAFYS
     GNHLAQFDCV VANPPFSLKN WGESEWVSDK WGRNNLGGVP PKGYADWAWV QHMLTSARTQ
     NGRVAVVLPQ GALFRQGAEA RIRTHILKAD LVESVIGLAP NLFYGTGLAA CVLILRHEKR
     PEKKGKVLFI NGNKLFKRGR NQNTLETEHA ERLLDAYELY QDQDGLSRVV NLAEIAGHGY
     SLNIPLYVAP EDEGEELTLA DALANLEAAH TKTAETRRAL EAELAKWGVG QEILA
//
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