ID A0A024HCY6_PSEKB Unreviewed; 752 AA.
AC A0A024HCY6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:CDF82721.1};
GN ORFNames=PKB_1358 {ECO:0000313|EMBL:CDF82721.1};
OS Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1301098 {ECO:0000313|EMBL:CDF82721.1, ECO:0000313|Proteomes:UP000025241};
RN [1] {ECO:0000313|EMBL:CDF82721.1, ECO:0000313|Proteomes:UP000025241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B13 {ECO:0000313|EMBL:CDF82721.1,
RC ECO:0000313|Proteomes:UP000025241};
RA Linke B.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDF82721.1, ECO:0000313|Proteomes:UP000025241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B13 {ECO:0000313|EMBL:CDF82721.1,
RC ECO:0000313|Proteomes:UP000025241};
RA Miyazaki R., Bertelli C., Falquet L., Robinson-Rechavi M., Gharib W.,
RA Roy S., Van der Meer J.R.;
RT "Genome sequence of the 3-chlorobenzoate degrading bacterium Pseudomonas
RT knackmussii B13 shows multiple evidence for horizontal gene transfer.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; HG322950; CDF82721.1; -; Genomic_DNA.
DR RefSeq; WP_043250111.1; NZ_HG322950.1.
DR AlphaFoldDB; A0A024HCY6; -.
DR STRING; 1301098.PKB_1358; -.
DR KEGG; pkc:PKB_1358; -.
DR PATRIC; fig|1301098.3.peg.1350; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_6; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000025241; Chromosome.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CDF82721.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000025241};
KW Transferase {ECO:0000313|EMBL:CDF82721.1}.
FT DOMAIN 415..476
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 672..747
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 752 AA; 84356 MW; 81DED38560C2CABA CRC64;
MVQVRAHQPV NTDGSINLEA WLDHVQTLVP VLDRKVLLEA CEFARAAENK AASQVDTAWA
EGTSSFQTGL EIAEILADLK LDQESLVAAV IYRGVREGKI KLEEVQQRFG SVVAKLIEGV
LRMAAISTSL NPRQSLVLGT QAQIENLRKM LVAMVDDVRV ALIKLAERTC AIRAVKNADE
EKRMRVAREV FDIYAPLAHR LGIGHIKWEL EDLSFRYLEP DQYKQIAKLL HERRLDREQY
IATVMQQLKD ALAATGIKAD LSGRAKHIYS IWRKMQRKGL DFSQIYDVRA VRVLVPEMRD
CYTALGIVHT LWRHIPKEFD DYIANPKENG YRSLHTAVIG PEGKVLEVQI RTHSMHEEAE
LGVCAHWRYK GTDVKSGSNH YEEKISWLRQ VLEWHEELGD IGGLAEQLRV DIEPDRVYVF
TPDGHAIDLP KGSTPLDFAY RVHTEVGHNC RGAKINGRIV PLNYSLQTGE QVEIITGKHS
GPSRDWLNQN LGYVTTSRAR AKIVHWFKLQ ARDQNVAAGK TMLERELGRL ALPPVDFEKL
AEKANYKTGE DLFAALGAGD LRLAHVVGYA QALVEPERGN EQLELIPRKP SRIGHGKRGD
IQIQGVGNLL TQMAGCCQPL PGDPIVGYIT LGRGVTIHRQ DCATVLQLGS REPERMIQVS
WGPVPVQTYP VDIVIRAYDR SGLLRDVSQV LLNERINVLA VNTRSDKEDN TAVMRLTIEI
PGLDSLGRLL ARISQLPNII EARRDRAGGK DV
//
