ID A0A024JVH5_9MYCO Unreviewed; 1785 AA.
AC A0A024JVH5;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Phenolpthiocerol synthesis type-I polyketide synthase PpsD {ECO:0000313|EMBL:CDO87835.1};
GN Name=ppsD {ECO:0000313|EMBL:CDO87835.1};
GN ORFNames=BN973_02193 {ECO:0000313|EMBL:CDO87835.1};
OS Mycobacterium triplex.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=47839 {ECO:0000313|EMBL:CDO87835.1};
RN [1] {ECO:0000313|EMBL:CDO87835.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44626 {ECO:0000313|EMBL:CDO87835.1};
RX PubMed=24874681; DOI=10.1128/genomeA.00499-14;
RA Sassi M., Croce O., Robert C., Raoult D., Drancourt M.;
RT "Draft Genome Sequence of Mycobacterium triplex DSM 44626.";
RL Genome Announc. Announc.2:e00499-e00414(2014).
RN [2] {ECO:0000313|EMBL:CDO87835.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 44626 {ECO:0000313|EMBL:CDO87835.1};
RA Xu Y.W., Yang Q.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG964446; CDO87835.1; -; Genomic_DNA.
DR RefSeq; WP_036467984.1; NZ_LQPY01000034.1.
DR STRING; 47839.BN973_02193; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_2_11; -.
DR OrthoDB; 9778690at2; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 35..456
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1673..1748
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1016..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1756..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 186893 MW; AEEEC4106AC42358 CRC64;
MTSLAERAAQ MSPKAREVLA RELVRAGTAF PTDVAEPIAV VGIGCRLPGK VAGPEDFWQL
LVDGRDAVGE VPADRWDGDA FYDPDPQAPG RMTTKWGGFL DDVAGFDADF FGITPREAVA
MDPQQRILLE VAWEALEHAG LPPDSLSGSR TAAIMGVSAW DYTILNLERN TEIDAYMSTG
NPHSAAVGRI SYLLGLRGPA VAVDTACSSS LVAIHLACQN LRLRESDVAL AGGVHLSLSP
FTSIALSKWS ALSPTGRCKT FDALADGFVR GEGCGVVVLK RLADAVRDGD RVLGVVRGSA
INSDGRSNGM TAPNAAAQRD VINAALRMAD VTADSVNYVE THGTGTILGD PIEFEALAAT
YGGGDGRCAL GSVKTNIGHL EASAGVTGFI KAILAVNRGY IPRNLHFNRW NPAIDPSGTR
LFVPTEPTAW PTGGVRRAAV SSFGLSGTNA HVVVEQPPAP AAPPSIEPAV STLLVSGKSP
QRLAATAAAL ADWIAGPGAA IPLADVAHTV NHRRARHNWV GAVVARDHAA TVAGLRALAS
GTPAPGVVAG AESGPGSGTV FVYSGQGAQW AGMGRRLLAD EPAFATAVAD LEPEFVAQTG
FSLRQTLAEG SPVTGIDKIQ PLLVAIQLAL TALWRHYGVE PDAVIGHSMG EVSAAVVSGA
LTPAEGLRVI ATRSKLMAQL SGRGAMALLE LDAAGVEALI AEYPDVTLAV HAAPGQSVIA
GPPDQVDAVV AAVGARNLLA RRIEVDVASH HPIIDPILPQ LRSALADLAP KPPTIPMIIT
TMEGPAPLLD ADYWAANLRN PVRFHQAVST AAADHHTFIE ISPHPLLTHS INDTLGEANA
HTLGTLQRDT DDTVAFHAQL AAVGNAAATD GRLADIPVAP WEHTHYWIDD RSAVSNSVAT
HPLLGVHIEV PSSRDHVWQA DVGTAVSPWL ADHKVFGQAV MPGAGFTEIA LAAASEALGV
PARAVSLNQV EVEQMLTLND HTQLTTRLMR GADDKIRIEI YSRSAGNDWT RHATARAEVR
TPEASPEPPA PGGGETAINP AQVYAALRAA GQFHGPAFAA LTAIHRLPGG AVETEIVLPD
ESPWHPDFRL HPVMLDAALQ SLAAAIPDDE LAGSAEASYL PVSFESVRVY GDPGRRARCR
AQLSGLDEGG AGKLGRIVLT DDTGTVTAEI NDIYVRRVER RSVPLPLSQK IFDTAWVPRP
VGAGPSDTPG SWLVLTDGNS AEADRFVAGW RSPAHRVVTA DLHDESAVLA AFADSAADPD
RPPVGVVVFV APNPNVSAAG IAQAREAVWS VSTVVRTIIG GWHGQPPRLW LVSCGGLPVG
DEAGQPGIGA LKGLVRVLAY EHPELRSTLV DLDVGHDPVG ALNAELESVA DGSIEDMIAW
RGGQRYVERL SRATLGEPTR ADVVRSGASY IITGGLGGLG LVFARWLADS GAGRIVLGGR
SEPSEEQRAV LAELERKTEI LVVSGDLAVD GVAEKLVAAA GESSLRGILH AAAVLDDSLV
FSMTKDSVQR VWAPKVIGAL RMHEASAGCE LDWWLGFSST SSLLGGPGQA SYACASAWLD
ALIDWRRAAG LPAAVINWGP WAEVGLARSL TGGPLDPITP AEGVAALEPL LAAGRCHTGV
ARLRPDRALI AFPEIRNLGY FTSVVDELEA AGDGGNWAGP EALAGLDPDQ ARAAIAERLH
ARIAAVMGYA EPSAVDADLP LVELGMDSLM AVRIRNSARA DFGAEPPVAL LLQGATLNDL
TAELLRQLGL TGDAQAHQQQ GAVRDRAQQR AAARQQAAQR RKRGR
//
