ID A0A024JXX2_9MYCO Unreviewed; 647 AA.
AC A0A024JXX2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BN973_02452 {ECO:0000313|EMBL:CDO88093.1};
OS Mycobacterium triplex.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=47839 {ECO:0000313|EMBL:CDO88093.1};
RN [1] {ECO:0000313|EMBL:CDO88093.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44626 {ECO:0000313|EMBL:CDO88093.1};
RX PubMed=24874681; DOI=10.1128/genomeA.00499-14;
RA Sassi M., Croce O., Robert C., Raoult D., Drancourt M.;
RT "Draft Genome Sequence of Mycobacterium triplex DSM 44626.";
RL Genome Announc. Announc.2:e00499-e00414(2014).
RN [2] {ECO:0000313|EMBL:CDO88093.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 44626 {ECO:0000313|EMBL:CDO88093.1};
RA Urmite Genomes U.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; HG964446; CDO88093.1; -; Genomic_DNA.
DR RefSeq; WP_036468336.1; NZ_LQPY01000034.1.
DR AlphaFoldDB; A0A024JXX2; -.
DR STRING; 47839.BN973_02452; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG3391; Bacteria.
DR HOGENOM; CLU_000288_63_44_11; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14952; NHL_PKND_like; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035016; NHL_PKND.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR PANTHER; PTHR43289:SF37; SERINE_THREONINE-PROTEIN KINASE A; 1.
DR Pfam; PF01436; NHL; 3.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51125; NHL; 4.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CDO88093.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:CDO88093.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..270
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 406..434
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 435..476
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 524..560
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 578..605
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 281..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 69004 MW; 6311A48B3DD4639C CRC64;
MEGKEFGRYR LVELMGRGDL GEVWRAYDTE TADRTAAIKL LPPQLAADPA IAEQFRREAA
AAARLNNPHI VPIHGYGEIG EQLYLDMEFI DGRNLQEVLA DGPIEPARAV RIIGQVAQAL
HAAHGVGLVH GDVKPSDILL DRDDSAYLVD LGLARLAPWY ETRLANSDKE IASWHYMAPE
RSGAREADAR ADIYSLACVF YECLTGQPPF AGDTWLFAAH LSTPPPRPSA NRPGVPPGLD
AVIATGMAKD PANRYATAIA MADAAQHAIA PPPLRRKQVP NMAKHAVPDG QPPQPEPLPA
ANRHVAPPPP PVTSYLAVEA SPAEEPSDLE PFKQPWPDEV ETSPRRPWWR RPVIVIPAAL
LTAAVVVVAV VVIVVRFESG RTKQAAVHHD PVFGPQITLP FNGLGHPADV EVDPAGNVYV
ADDMNNRVLK LAAGSSTVVQ LPFTGLNSPE GVAGDSAGNL YVADTNNNRV LKLAAGTNTP
IVLPFNGLHR PQGVATDDAG ALYLADTDAN RVLELTPGSN SPIELPFTGL NGPEGVGLDN
ARNVYIADSG NSRVVKLAAE SGRQSVVPFS GLFRPGDPSG VAVDSGGDIF VTDYTNNRVL
KMEAGTGRQS VLPFVGLNHP SGIAVDKAVN IFVTDYTGDR VVKLPAE
//
