ID A0A024P4Y2_9BACI Unreviewed; 394 AA.
AC A0A024P4Y2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Alanine--tRNA ligase {ECO:0000313|EMBL:CDQ23838.1};
GN Name=alaS_1 {ECO:0000313|EMBL:CDQ23838.1};
GN ORFNames=BN983_02091 {ECO:0000313|EMBL:CDQ23838.1};
OS Halobacillus karajensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX NCBI_TaxID=195088 {ECO:0000313|EMBL:CDQ23838.1, ECO:0000313|Proteomes:UP000028868};
RN [1] {ECO:0000313|EMBL:CDQ23838.1, ECO:0000313|Proteomes:UP000028868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HD-03 {ECO:0000313|EMBL:CDQ23838.1,
RC ECO:0000313|Proteomes:UP000028868};
RA Urmite Genomes U.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDQ23838.1, ECO:0000313|Proteomes:UP000028868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HD-03 {ECO:0000313|EMBL:CDQ23838.1,
RC ECO:0000313|Proteomes:UP000028868};
RA Khelaifia S., Croce O., Lagier J.C., Raoult D.;
RT "Draft genome sequence of Halobacillus karajensis HK-03.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDQ23838.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CCDI010000002; CDQ23838.1; -; Genomic_DNA.
DR RefSeq; WP_035508208.1; NZ_CCDJ010000002.1.
DR AlphaFoldDB; A0A024P4Y2; -.
DR Proteomes; UP000028868; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 2.40.30.130; -; 1.
DR Gene3D; 3.10.310.40; -; 1.
DR InterPro; IPR018165; Ala-tRNA-synth_IIc_core.
DR InterPro; IPR003156; DHHA1_dom.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR012947; tRNA_SAD.
DR PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR Pfam; PF02272; DHHA1; 1.
DR Pfam; PF07973; tRNA_SAD; 1.
DR SMART; SM00863; tRNA_SAD; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Ligase {ECO:0000313|EMBL:CDQ23838.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028868}.
FT DOMAIN 1..237
FT /note="Alanyl-transfer RNA synthetases family profile"
FT /evidence="ECO:0000259|PROSITE:PS50860"
FT COILED 260..287
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 394 AA; 44676 MW; CF1160083E2C8F4D CRC64;
MTRKLYYLDA YQMEFKSKVT NIDEDDRGPY IVLEETAFYP TGGGQPHDIG ILNGIEVIDV
EEVEGEIRHY TKEKFPDGIE NVQGTIDSKR RIDHMQQHCG QHIISAVFHD QFEILTTSFH
LGKNTVTIDL DTERLTDELV RRAEDQVNQI IRDNAPVESK WMSVDEASDY PLRKPLVVEG
DVRLVIIPGI DYNGCGGTHP RFTGEVMAAK FLGWTKNKKQ VRLEFVCGHR VLDKLGQKHR
VLTELKRIVQ KPESELVAEI GELIKSNKER DKQIADLEEQ ALKYEAKDII ANSQDKQVIQ
CVFKDRPIQT LQSLGKAIIE QAAYAYLILI SEQEHQLQFV LAHGEDLDRN MNEVAKKTMP
LIEGRGGGKP NFVQGGGKRL IDGAAFAERV KSLL
//
