ID A0A024TAB3_9STRA Unreviewed; 289 AA.
AC A0A024TAB3;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Peroxisomal trans-2-enoyl-CoA reductase {ECO:0000256|ARBA:ARBA00041063};
DE EC=1.3.1.38 {ECO:0000256|ARBA:ARBA00038849};
GN ORFNames=H310_07822 {ECO:0000313|EMBL:ETV99770.1}, H310_14887
GN {ECO:0000313|EMBL:ETV90287.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV90287.1};
RN [1] {ECO:0000313|EMBL:ETV90287.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV90287.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in chain elongation of fatty acids. Catalyzes
CC the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1
CC to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA
CC reductase activity. {ECO:0000256|ARBA:ARBA00037124}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+);
CC Xref=Rhea:RHEA:44960, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430;
CC Evidence={ECO:0000256|ARBA:ARBA00036396};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44961;
CC Evidence={ECO:0000256|ARBA:ARBA00036396};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+);
CC Xref=Rhea:RHEA:44964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57330,
CC ChEBI:CHEBI:57375, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00036112};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44965;
CC Evidence={ECO:0000256|ARBA:ARBA00036112};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+);
CC Xref=Rhea:RHEA:44956, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620;
CC Evidence={ECO:0000256|ARBA:ARBA00035816};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44957;
CC Evidence={ECO:0000256|ARBA:ARBA00035816};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA;
CC Xref=Rhea:RHEA:44952, ChEBI:CHEBI:15378, ChEBI:CHEBI:57386,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62242;
CC Evidence={ECO:0000256|ARBA:ARBA00036220};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44953;
CC Evidence={ECO:0000256|ARBA:ARBA00036220};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) +
CC tetradecanoyl-CoA; Xref=Rhea:RHEA:44968, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57385, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:61405; Evidence={ECO:0000256|ARBA:ARBA00036815};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44969;
CC Evidence={ECO:0000256|ARBA:ARBA00036815};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA +
CC NADP(+); Xref=Rhea:RHEA:33763, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.1.38;
CC Evidence={ECO:0000256|ARBA:ARBA00036518};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33764;
CC Evidence={ECO:0000256|ARBA:ARBA00036518};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SUBUNIT: Interacts with PEX5, probably required to target it into
CC peroxisomes. {ECO:0000256|ARBA:ARBA00038622}.
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DR EMBL; KI914051; ETV90287.1; -; Genomic_DNA.
DR EMBL; KI913966; ETV99770.1; -; Genomic_DNA.
DR EMBL; KI913966; ETV99771.1; -; Genomic_DNA.
DR RefSeq; XP_008871546.1; XM_008873324.1.
DR RefSeq; XP_008871547.1; XM_008873325.1.
DR RefSeq; XP_008881072.1; XM_008882850.1.
DR AlphaFoldDB; A0A024TAB3; -.
DR STRING; 157072.A0A024TAB3; -.
DR EnsemblFungi; H310_07822-t26_1; H310_07822-t26_1-p1; H310_07822.
DR EnsemblFungi; H310_07822-t26_3; H310_07822-t26_3-p1; H310_07822.
DR EnsemblFungi; H310_14887-t26_1; H310_14887-t26_1-p1; H310_14887.
DR EnsemblProtists; ETV90287; ETV90287; H310_14887.
DR EnsemblProtists; ETV99770; ETV99770; H310_07822.
DR EnsemblProtists; ETV99771; ETV99771; H310_07822.
DR GeneID; 20084872; -.
DR GeneID; 20091937; -.
DR VEuPathDB; FungiDB:H310_07822; -.
DR VEuPathDB; FungiDB:H310_14887; -.
DR eggNOG; KOG0725; Eukaryota.
DR OrthoDB; 2731281at2759; -.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR24317; PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE; 1.
DR PANTHER; PTHR24317:SF7; PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
SQ SEQUENCE 289 AA; 30687 MW; BD9CF3E2CB826F6B CRC64;
MTIRGATTVF RDGVFDGRVA VVTGGGTGIG KTIAHELCLL GCSVVLASRT LEMLVAAADE
IKAQLPTKHS SRSNVVVPIA CDVRDEGQVK RLFERVMSVF HRVDYVVNNA GGQFVSPFEN
LSLNGWNAVH RLNSTGTFLV TKYAFEAYLK DHGGAIVNVL VAMDKGFPYA SHSGASRAAV
ENLTKSLAYE WASRGIRVNA VTPGTIESSG LKNYGPVAQQ VCESYSANTP ARRLGTVEEV
SAAVVFLLSP AAAYTTGTNA LVDGGWNLAG ALVPLPQHIR YPVYGASKL
//
