ID A0A024TBV2_9STRA Unreviewed; 395 AA.
AC A0A024TBV2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288, ECO:0000256|RuleBase:RU000554};
GN ORFNames=DYB32_007170 {ECO:0000313|EMBL:RHY26906.1}, H310_14244
GN {ECO:0000313|EMBL:ETV91081.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV91081.1};
RN [1] {ECO:0000313|EMBL:ETV91081.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV91081.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RHY26906.1, ECO:0000313|Proteomes:UP000285060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM0002 {ECO:0000313|EMBL:RHY26906.1,
RC ECO:0000313|Proteomes:UP000285060};
RA Minardi D., Oidtmann B., Van Der Giezen M., Studholme D.J.;
RT "Aphanomyces genome sequencing and annotation.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000554};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804, ECO:0000256|RuleBase:RU000554}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935, ECO:0000256|RuleBase:RU004169}.
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DR EMBL; KI914015; ETV91081.1; -; Genomic_DNA.
DR EMBL; QUSY01000882; RHY26906.1; -; Genomic_DNA.
DR RefSeq; XP_008880277.1; XM_008882055.1.
DR AlphaFoldDB; A0A024TBV2; -.
DR STRING; 157072.A0A024TBV2; -.
DR EnsemblFungi; H310_14244-t26_1; H310_14244-t26_1-p1; H310_14244.
DR EnsemblProtists; ETV91081; ETV91081; H310_14244.
DR GeneID; 20091294; -.
DR VEuPathDB; FungiDB:H310_14244; -.
DR eggNOG; KOG2872; Eukaryota.
DR OrthoDB; 34606at2759; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000285060; Unassembled WGS sequence.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR HAMAP; MF_00218; URO_D; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00906; UROD_1; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793,
KW ECO:0000256|RuleBase:RU000554};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000554};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU000554};
KW Reference proteome {ECO:0000313|Proteomes:UP000285060};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..395
FT /note="Uroporphyrinogen decarboxylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038289897"
FT DOMAIN 67..76
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00906"
FT DOMAIN 188..204
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 395 AA; 43867 MW; 1098AD2CB2C525E5 CRC64;
MARVVIPLVA LAISSVLFAA VRRRAKKERP FPSVRTPIKR VPLDELPKLK NDLVIRAYLG
QPTERVPVWC MRQAGRHLPE FRALRQAGYD FFTMCGVPEL AAEVTLQPVR RYNVDAAIIF
SDILVVPQAM GMEVVMLPGV GPVLPAPLRT PADLDRLVEH PDIEATLGYN LDAINLTRQL
LKGQVPLIGF CGGPFTLFTY MVEGGASKTK SKVKTWLYNH PEAAHRALHA ITDVCVRFLL
EQHAAGAQAL QVFESVGAEV LTQAHFYEFA FTYMAQIADR VKDKLPDVPL VGFSKGTPYA
FEQLATTKYD CLGLDWTMDP VAVRQQTGDR VSLQGNLDSA AIYAEPETIR NEVKKMLDAF
GTQKYVANFG HGCNPDFDPE RVDTFVKAVQ QLSLQ
//
