ID A0A024TET1_9STRA Unreviewed; 415 AA.
AC A0A024TET1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=23S rRNA methyltransferase {ECO:0000313|EMBL:ETV91842.1};
GN ORFNames=H310_13668 {ECO:0000313|EMBL:ETV91842.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV91842.1};
RN [1] {ECO:0000313|EMBL:ETV91842.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV91842.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI914006; ETV91842.1; -; Genomic_DNA.
DR RefSeq; XP_008879479.1; XM_008881257.1.
DR AlphaFoldDB; A0A024TET1; -.
DR STRING; 157072.A0A024TET1; -.
DR EnsemblFungi; H310_13668-t26_1; H310_13668-t26_1-p1; H310_13668.
DR EnsemblProtists; ETV91842; ETV91842; H310_13668.
DR GeneID; 20090718; -.
DR VEuPathDB; FungiDB:H310_13668; -.
DR eggNOG; ENOG502QQ98; Eukaryota.
DR OrthoDB; 276083at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0070475; P:rRNA base methylation; IEA:InterPro.
DR GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR040072; Methyltransferase_A.
DR InterPro; IPR027492; RNA_MTrfase_RlmN.
DR InterPro; IPR004383; rRNA_lsu_MTrfase_RlmN/Cfr.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR00048; rRNA_mod_RlmN; 1.
DR PANTHER; PTHR30544; 23S RRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30544:SF8; RADICAL SAM SUPERFAMILY PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF006004; CHP00048; 1.
DR SFLD; SFLDF00275; adenosine_C2_methyltransferase; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ETV91842.1};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETV91842.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..337
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 357..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 45563 MW; 6A7A6B8B32BB3D8B CRC64;
MVKKRVLSPA PLLDPALLTA FVEANGLKLV HAQKIWKHIS AQVQTQSTAN ISVRDVLHLP
SHAYPLLEDS FATFTTTVTE QHTSSDGTVK LLITLQDGHN IESVIMKHSG RNTLCVSSQV
GCQMGCTFCA TGTMGIIADL CAGEILEQLA HAFRVAPIRN VVFMGMGEPL NNYDAVLTAI
RAMTDIFGLA PKYITLSTVG VIHRIRQLKE DAPLVRLALS LHAPTQDLRV QIVPTAKAYP
LDKLMLAIDD HLKDRENRMV MMEYIMLKDV NVAPDTAHDL GRLLQGKSVH INLIPYNATD
VDAEFQSPSQ DEIVAFKDIL RAEYHLKVTV RENHGMDIDG ACGQLAVKKL EAGLPKSSGL
DQRDIEDLGK RTNKAPKPSK KQTKTDDTSA TALFVAMPIL AIVAAAAFVW RRLQQ
//
