ID A0A024TKD1_9STRA Unreviewed; 284 AA.
AC A0A024TKD1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-79 specific {ECO:0000256|ARBA:ARBA00020987};
DE EC=2.1.1.360 {ECO:0000256|ARBA:ARBA00012190};
DE AltName: Full=Histone H3-K79 methyltransferase {ECO:0000256|ARBA:ARBA00029821};
GN ORFNames=H310_11877 {ECO:0000313|EMBL:ETV94615.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV94615.1};
RN [1] {ECO:0000313|EMBL:ETV94615.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV94615.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60328, Rhea:RHEA-COMP:15549, Rhea:RHEA-
CC COMP:15552, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.360;
CC Evidence={ECO:0000256|ARBA:ARBA00001569};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI913985; ETV94615.1; -; Genomic_DNA.
DR RefSeq; XP_008876930.1; XM_008878708.1.
DR AlphaFoldDB; A0A024TKD1; -.
DR STRING; 157072.A0A024TKD1; -.
DR EnsemblFungi; H310_11877-t26_1; H310_11877-t26_1-p1; H310_11877.
DR EnsemblProtists; ETV94615; ETV94615; H310_11877.
DR GeneID; 20088927; -.
DR VEuPathDB; FungiDB:H310_11877; -.
DR eggNOG; ENOG502S1KF; Eukaryota.
DR OrthoDB; 54777at2759; -.
DR GO; GO:0140956; F:histone H3K79 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025789; DOT1_dom.
DR InterPro; IPR030445; H3-K79_meTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR21451; HISTONE H3 METHYLTRANSFERASE; 1.
DR PANTHER; PTHR21451:SF0; HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC; 1.
DR Pfam; PF08123; DOT1; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 115..250
FT /note="DOT1"
FT /evidence="ECO:0000259|Pfam:PF08123"
SQ SEQUENCE 284 AA; 31910 MW; F55F300B417E02FC CRC64;
MTDLNNLRSR VAASAHSLPA QMFHIAGHLH RHGVISGIGK ALLKEVVFQQ DVRGPKLVDT
LFSSSDEHWL KFVHRLLDVE TLKLFDSLYL DYPLEQGKAI SRQEREDNGM LTQKSLVYGE
VDYLAFLATL RKIPIEPHWT FTDLGSGTGR AVFIARLNFD FSRCTGIEIL RGLHDAAADV
CSNYNEFVRP VVSTTSTPLE ASFFHCSLLD LDWSHTDVCF ANSTCFDSAL IAAMAEKASA
MRPGSYFITF TKPLPADIAP FDIVDKERRN MSWGPATVYI HQRR
//
