ID A0A024TSB6_9STRA Unreviewed; 503 AA.
AC A0A024TSB6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Adenine DNA glycosylase {ECO:0000256|ARBA:ARBA00022023};
DE EC=3.2.2.31 {ECO:0000256|ARBA:ARBA00012045};
GN ORFNames=H310_10240 {ECO:0000313|EMBL:ETV96521.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV96521.1};
RN [1] {ECO:0000313|EMBL:ETV96521.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV96521.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC apurinic site.; EC=3.2.2.31;
CC Evidence={ECO:0000256|ARBA:ARBA00000843};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the Nth/MutY family.
CC {ECO:0000256|ARBA:ARBA00008343}.
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DR EMBL; KI913976; ETV96521.1; -; Genomic_DNA.
DR RefSeq; XP_008874787.1; XM_008876565.1.
DR AlphaFoldDB; A0A024TSB6; -.
DR STRING; 157072.A0A024TSB6; -.
DR EnsemblFungi; H310_10240-t26_4; H310_10240-t26_4-p1; H310_10240.
DR EnsemblProtists; ETV96521; ETV96521; H310_10240.
DR GeneID; 20087290; -.
DR VEuPathDB; FungiDB:H310_10240; -.
DR eggNOG; KOG2457; Eukaryota.
DR OrthoDB; 123472at2759; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd00056; ENDO3c; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR004036; Endonuclease-III-like_CS2.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR000445; HhH_motif.
DR InterPro; IPR044298; MIG/MutY.
DR InterPro; IPR029119; MutY_C.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR PANTHER; PTHR42944; ADENINE DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR42944:SF1; ADENINE DNA GLYCOSYLASE; 1.
DR Pfam; PF00633; HHH; 1.
DR Pfam; PF00730; HhH-GPD; 1.
DR Pfam; PF14815; NUDIX_4; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS01155; ENDONUCLEASE_III_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 67..207
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
SQ SEQUENCE 503 AA; 56113 MW; EB7B57FAFFB05059 CRC64;
MKHNHAWKAT EVAGISSALL KWYDTQRRCL PWRGDSTPYL VRVNERDTDY CAPNVVTPYG
TWVSEIMCQQ TRVDTVVAYY TKWMDTFPTV QSLAAADPDQ VNAVWAGLGY YRRARMLHQG
AQFVMDKFNG NMPHDIETLK TIPGIGPYTA GAIASVAFNQ AEPLVDGNVI RVISRLRAIG
GDPNHKPLIK FCWWGRLFSL LNRLSAHPVA LGRFRESGKR LIDPSRPGDF NQALMELGAT
VCSIQTPACA TCPVQSFCHA YAQFKEDGST SPNNAPLQVE CAVCDLTRLE EWGVDAPAAV
TKFPLKTRKK APRSEVISVA VVYRQPGDTM ESRQYLMAKR SDRGLLAGQW EFLTSKATHD
SDNVSDYAMR RTWANDGIAT ALSIRPETLE GLIVRRCDRG ELVHVFSHVK HHMGVEEVEV
DWPGVTKQLE SPMVRWMSCQ DMAEVGITTG MKKVLNLVVK ADSKARAVTR HAASSRHVKP
KVVDNETRPI TAFFQFAAKS ATE
//
