ID A0A024U1F2_9STRA Unreviewed; 975 AA.
AC A0A024U1F2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Insulin-degrading enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=H310_07510 {ECO:0000313|EMBL:ETW00084.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW00084.1};
RN [1] {ECO:0000313|EMBL:ETW00084.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW00084.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; KI913965; ETW00084.1; -; Genomic_DNA.
DR RefSeq; XP_008871109.1; XM_008872887.1.
DR AlphaFoldDB; A0A024U1F2; -.
DR STRING; 157072.A0A024U1F2; -.
DR MEROPS; M16.008; -.
DR EnsemblFungi; H310_07510-t26_1; H310_07510-t26_1-p1; H310_07510.
DR EnsemblProtists; ETW00084; ETW00084; H310_07510.
DR GeneID; 20084560; -.
DR VEuPathDB; FungiDB:H310_07510; -.
DR eggNOG; KOG0959; Eukaryota.
DR OrthoDB; 129328at2759; -.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 32..164
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 191..370
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 376..656
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 660..836
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 975 AA; 109567 MW; D7EF1CB2CD1D0A87 CRC64;
MEKSVRQKGG IDISAGDERD YRHVRLENGL CVLLVSDSEA EKSAAAMDVR VGHQSDPDNL
LGLAHFLEHM LFMGTKKYPD ENSYSQFLSA HGGSSNAYTS GTDTNYYFDV RPPYFEEALD
RFAQFFIAPL FTPGATEREM NAVNSENNKN LQSDPWRVDQ IVKHTSSRRH PFHKFGTGNL
VTLGTAPTEV VRAELLAFHA KYYSARIMKL AIVGKEDLDT LEEWARSKFS EILDTGDKTF
HYEGVPFEGP QLQRRVNVVP VKDHRSIEVS WPLPSLRSSY LQKPTSLISH LLGHEGSGSL
LSLLKRQKWV NELSAGLMKE YDDWSLFCVE VEATEVGMAH VDEIVDSIYQ YLHLLQTDGI
APWVFEETQS IALMNFRFRS KETPMNYATA LATRMQLYPV QHIVAGSSLL YEYDPIQVKS
IFSLLTPDRM RLLVVGKEFE GTTTDVEPWY ETAYSDTPIE PSLIERWSNP ARSAALFCPH
PNAFIPHNFD LVATATPGAV PILLRDDAAA RLWVKTDTTF FKPKLNICLA FHSPVIYNSP
TSVVLTDLLV RAIKDQLTEF TYDAELAGMR YSLSFTTTAV ELYGGGYSDK LPVLFDLILK
QIVQFDVDNE TFGRLQDKTK RSYDNFERDD PYKHALYFSS CLLEDTKWTV TEKAAAIAHV
TRADLVHHAA ALFRELFVEA YYHGNVDAAT TTALLDNVLA TVQARPVIPS QRVKTRAIKL
ASPAEYVYAI PELNAESVNS GIYTVFQLGP ESIHLRATNE VFAQLVREPC FNQLRTQEQL
GYIVFSSSHR AHGIEYFRII VQSDVASPAY VERSIEAFLK LVRRDIAALS HDEFQKNLQA
VVDALLDKPK AASEECSRFW SEISAETIAA VFQQKTVTFE KRVMTYLALL HPFLYRKFGK
GNQGIQHQVR GINPSKKPAH GVLPVSISAK MTALHLTVQS SKNFLAASRR FGPCAATPTA
GIVKNTTCLS KPVSR
//