ID A0A024U7B6_9STRA Unreviewed; 4983 AA.
AC A0A024U7B6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=H310_05858 {ECO:0000313|EMBL:ETW02311.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW02311.1};
RN [1] {ECO:0000313|EMBL:ETW02311.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW02311.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI913961; ETW02311.1; -; Genomic_DNA.
DR RefSeq; XP_008868916.1; XM_008870694.1.
DR STRING; 157072.A0A024U7B6; -.
DR EnsemblFungi; H310_05858-t26_1; H310_05858-t26_1-p1; H310_05858.
DR EnsemblProtists; ETW02311; ETW02311; H310_05858.
DR GeneID; 20082908; -.
DR VEuPathDB; FungiDB:H310_05858; -.
DR eggNOG; KOG3595; Eukaryota.
DR OrthoDB; 53982at2759; -.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT DOMAIN 741..776
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3444..3499
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4983 AA; 556254 MW; BABF4C2753D106A0 CRC64;
MASQKDDANR RSEKTHYNAT TPEERMLQRG ELPMSFASRR RRPDRSHRPM SAGPCALSNQ
ALDGTINELA SQLVLVSPRT NNNASPMDSA PSSLMSPKKE RAASAAPTRP TTTSNPRNMI
RPKSSTAQRK LTLSGEARRD GVPWSPLHLA GPLQRAADKN HQHLSSGISP PLVKVPAPPS
SAYQLSNVTD LLPPSSGPML SRPQSAAPTK LLSKRGLNRP RTAVAKSPTK RIKTNRPSNE
ASPAPQNQQT VDDNAPGMHV STVEKAVDVE LSHKNTSRKS KQWSPPKHFT ALRQTPMKSP
SKPVASSSPL PTSTTPIVPL DTLQTVRTSI ENWIHRREND RSTDRCLSDA NDTFRYAVPA
HHFDRSAPYD PYTITYVPFH HVYKVTDGAP HGLQFTDDDR VIDQQIACDF YVMSSKNVLY
YNKDHATVTF QSMPEWDRER RIFQRLKTLA LFSTYRRTKA MKCWVSHYIL CKRQRCKDQL
NDLLYFCNSI FHATMEKIQA KMAVLHTQLL FYVDSATVIP PEEFQRRQGI HIQKLGHEFI
ALFHAIREIL VAMSHTYLSQ YSSTDAVIKY ADVSLTSRKS TTFHMDQFFG NVQKKSPLSP
LATCNEDNTG ELDLVAIRAE LQRSRVRAKS RESIKEKPTM DAIKWSVAAV KRARCSELSR
FIRRVDFMLL DAFHGVINRS AAALGQLLET GAGKSSSLLL SKDAYMRAYH RFDIYGNGAL
DCAQITRLLH HVFDGKLTGA ALEERVGLFI SVFDENGDGD VSIEEFSKGL DVVLDVERMQ
QFDASANSIY ETTRMAHTNL FIPVPLFEVQ LVFDGTGLSF EPPLKSVQSA VEMTLRGFFD
ANEHVQRLIT DPTILPVLTF YDQVRTSHLD SCAPQVATAP GGDHPQDARI SLILFERASQ
DQAYMHLCEQ IFDIVKGSIC GCQAYANCFL PLCDEYDWNN ALDFDRIAQQ HLDGAYDMDQ
LKQDVQKFQH QKWMLEDVVV SQDIQLIRVK TNALKTALVP SPVRCLKELE RILPILAEKN
IARLLSYIEL VASKIQRPPA KDIEAFVTYI LNLKEINDEL PSKDLEAAQI SDYLELITDS
GFHIPSQTQA VYDLVEPELS TLKSAVTNCM ARRDMDIREY AVLLEQKMQH LEANIAYLQT
ESCAEQLFHA ETEALHALAF TGNLKQLATD YSSRSERFLY VRSLFNEFLP NCMPDIPNKG
GHFASLPKLT GDIQLKHDMW TLIMAADQSL ASWGDIALKD MPKADMEDLL RRVTELHRVL
AVEFPTSPVT ARVHGLQTLL LHMTSIVQNL CNPHVEDRHW RKLENKLNVV FQYEVEPATD
HRCLVRQGDI SFKYLVSLHI DDKHDEINDI VQEAATEAAI SKSLHDAIRV WDTQEIAFSY
WTDNDTRDVV VLGDTTECMN MLEESDMLLQ TILASSYIRP IQPLAMKWKH DVNEMMEIMM
RLEECKNYWE HMEVFLSPEF LRALPGQVRA YTELDRTWKV LLDKLSKNPS LVRTARTQGL
KEHIIQLSQG FEGIYKTLEG YLEIKRQSYP RFCTLSDSEL TDLISACRNP HNIQQYLPSC
FPSLGKVTFD TDDKSMGIVA VRSPPNPFEE VIPMGKNLKA RGYVEQWLSH MDRRLSERLH
KNIKELVVYF SGRPPAGWDL SHLRQFPLQC LLVANDVVTS TTIGNVEGNN DVAGGVVVRI
QQLTQALTSG DRTLHPVVTT TLLMQQFYFR DTLDNLSVIP WENHPHYTTT DDEVQLAIAD
MVIPYGYAYH NPTENYLVVT PLTERYLLAV FNCVQYYQAG LVSGGMSSGK TGLIQMATVM
LGRDLIQTFC TIHTSLKQIH RFITGGIGSG GTLLLQNADR MVGPILSFIN TVVSTIMNGA
LAAKHCVTLD EREHVVDAGS MIMLTTSVPS CLVSPYHFQA LCESLSSIAV VAPDLERVLH
AIFFSYGFEH ALTLARMLGF VWSELRGVST RLSTQPTMVQ LFTIHTAKQC AKQMFERSRG
TSITDEVGLL KETLLEYLTT RLNLPGGIRA HAMSYIKSMW LAKDHAVSVR EGDMESKDGH
NRTVFLSFLK AAYDKNQFIP SETLLQVSAA LVQAVVAYRT VILCGPMKTG KTTCVAMLAA
ALNNLFFDVD LANPTLPQFP QPPPPQSQFI VIKTLLPMSL SMAQLYGGSA DGNSDSSLIK
RLATENVPCP LLSGVDELKM NERDTVPQDV APLFTHRQRV WIVLDGTMDA AWAEHILSLA
GPAPSSSLTS GLGQFSLLGS DTFTIPSNVT ILLETIDLGH ASPTLVLNSS LIHVSDAPSR
PLVSKDLVQS TNSAVSAKLL PMHKMFLVGS IGRIRVQMTV PPLVCELLTK HLVDSSLLDR
LLEVLGEGST HAPLSHLHTA QHIMTLIHPV LSTQPGIDYT LWTKSLEFDS ALGYNEPRRL
LSRQIELCIL WSVCWGAGSC ASIQTKRLVT SVLQREFDHL QESWANCSGD MGLYSWVLDI
ASATFRSCKD VLCIPTGQRD ISPFSVYIPR VDSTLVHLVG RQVLRSGVPL LVFGPPDCGA
TSCVVEFLQR SSVFLSQGLT TLDKSTTATG SSDNAEAARI SNMRLTTTMI VSSLASRLKT
KRTSAVRSPR SSIVGKPGPP VRMCSPDDEA TTKLFEAGAF VSMRLQCTAS TTIDSLSTSV
EIVMQRERKQ VYEPPPGKAM ILFLDDVHLP LHSEFPSPHA WIRSMIDLSA VYRPSDTKTR
TIERTLLVAT ASDHAMGSWH RAPNACQARL LSRFFPVRLA ALEACDVSQI LTPIVVGLFE
RTDLHCRYVQ PIRHQIGHVL AVTIDVFVKC RALGTHVALA FGFSKLITML EFLTAVPPPA
LPDLPVLLRL WHHEIERTFV DTALAFDHGE AVQHIADTAY ASLCDLMKEK PAMRHTARWV
YFPHGYNEKP SMRHRQDSLD GSPIGQTPED RAASIGLGRR RCSINKAPPP LERMTSIVDS
SNLPQGKALL QRQNTAAKVA PTLQKTDSLR GGFAQRKNSG TFDYDALGTR RLSSRGILAP
GSCDHFGWNR HVYGELFNGL SEYADALPSL HAALQKQTLR FGESDNLILS VPMVGTTLQL
CRILGKPGGK AVLVGPPGHA KHSVAKMAAK IMDQQHVHFE ALMDKAVSET KWATALKEVV
TIAGVLQTDV TFIVQNAHRM SDACLEQLTS LLNSREVPLL FSPDEHVELA GRVKDEKLFE
LNALHSKQME NLRIELSVAK RSELQSKHDA VRRLIADSRE SHTKTAKERE LEAMIEVEKH
LNLQGQERID ALVSVQHSEM DDFIRKFEAN VDINMALTMA TVKPSGVVSG IWNEVVQAAA
RNVRVVVCCD ATDIPVFVQR VPKLFAQTQM CVLPRLDFDV IKPMVHLRIE TQWKVFQDHE
GHLDSTVLLN SLDLIQSNLN HVSTLAAKFH LAASRVMLAS GAAHAVISLH LIPLYSRYIF
DAMKRLRIRM NHLMSRSRAF LDVYQNAVDQ VDSAQKQYQE KQVQIQSALV QIGEYKLHFE
KMQAEAEVLR NVMRKQKADV DEQVKITTDM DKLTKHELKD ALKVLDDANK CVANLDRRYI
MEIKTFVNPP VLVHVVLNAM CVLFSVDPSW DNAKKLLSDV NFITSMLNYD KDNVPETILT
KLEPYLTNEM FNKAEVEKQS IAASTMVVWI IAIEAYSRSR KLVKPKLDIL DAAQAKLRTL
VGEFAECKKN VEQADRVSSD IEETIQARME DKKLMEAECQ TLTAFLVQGN AVLKILGPEQ
AVMTKQLQSM VEYEASLVAE AVVSAAVITY GGVFSPRLRR HLFDEWTREL DGQPLQIHPT
HSILNNYAAQ PFGLWLHAAG LFHSRHSQQT AYILAHALPV VLVTSFSPHM DSLLRNVLHS
VGCNSIVTKS ALDKDVRSVL ESCISMGQQL IVNDVTPRLY TSTFQDLVEW GTEWVDGVEY
INYIGHTLAL KRGFRLVLTT TAPLCEFGSE VFQVATVDAV ECWDDMQNVL LDDMELANVC
NDRVGVGAYD FARAILDMEV DMSRSFDGLL VHLRTMIRET KYDAPQVESL ATMCNQNAQH
RATFDERRQE LHRTMAARGD VSYAAVTQLG HQIFTALQKL ATLVPDLVMA FEPYGFRIFF
IQCLESCDGR SKAPGARCPP PGDVLVKLLE LLALTIPQLH WSSFLLLLAF EVRGGPAKDA
KASPPHLYDL ADDAPAEALS FMDLQRNVLF PPHWNASLTD ATINDMTATE QLFQAYEGIP
RDSVLMKRPR HLSMPSKQPS QQTDASVHSD GIQSIVSMPP QYHCLGVMLA GRPEAFASFC
DKLVLFTLGL EPKQPAARRT WHPKDWSKIL YNTQDAWFWC VVSNAGFSSL QLLYTVLDTI
VPRDMWPDVL KLLLQRPVVH ALSFHVPLDG GSIMGFFDSV PSMVQFEGLN PIAFESLRWF
VLDMTTPDKW DAVVQYNKKR RLDYRPVGLV SHLKPTLGKP MNQRHAADDD MQPSRMVHVV
PTTPAPTHTQ PLSVANVPLA VQPNRLVLHP LGSNPFSTEF RLTLLRLVAI PFSTAIGDAL
EGVNMDPAVR NVVAIVLWRL LCGLVFFHAA LVARQDKVVG CAVDMSTVDG SDLVLGVYMI
TGPLLQTIVR AFLETDDGDP LEQLNWGHIH NVFVQHAHGR KCRTHRGRHW IRALLRECIG
PYLLVPNSPP QQSKFQLPLP SFQDVLKTPT QSSEEYLTVM CAFASSCKWT VPDVVVPSAA
VSIDLRSLVL LPQHLNSPNH VKKHVLAIVQ LCLQSLPPAL PLKLHPRNAL VQHPLRQFLK
TVIHSFHHRR DHTELALQAL LSDITQASPA TVAAFVATTN NNDLKSALAM ECRALVLDKI
PARVATYAAP LDMSLSVAIK HWQRTGSFLQ LWWDEGQTEY WCPGIVDVTD LMAAFGFTYK
IATNTVANVD LLAFAGQVYP METPLDAFRN RNDTILLTGL ELLNAIPSPT TAGGIQEAAG
CAVPVQVLLK VSASPPPINA MECPILRSRC SSVSVGSLHV DIVPAIQEWA TCPYLVLSVD
DAR
//
