ID A0A024UEH9_9STRA Unreviewed; 1291 AA.
AC A0A024UEH9;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=H310_04416 {ECO:0000313|EMBL:ETW04023.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW04023.1};
RN [1] {ECO:0000313|EMBL:ETW04023.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW04023.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; KI913958; ETW04023.1; -; Genomic_DNA.
DR RefSeq; XP_008866979.1; XM_008868757.1.
DR EnsemblFungi; H310_04416-t26_1; H310_04416-t26_1-p1; H310_04416.
DR EnsemblProtists; ETW04023; ETW04023; H310_04416.
DR GeneID; 20081466; -.
DR VEuPathDB; FungiDB:H310_04416; -.
DR OrthoDB; 5490433at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 361..557
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 658..831
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 142835 MW; 0FB1993D0A0ECBE7 CRC64;
MVSQNNVKDH HTLKMADTTA AATTTPATDE EPTGLLSKEL MEELGGNEDD LLTVRKKKVK
GQAKPPSEEV MKAATKLSNS KRKKLAQLEA RKAKEARRDE VFQSLESKKL SQEHLNLMYS
TARLGHKETL KERLKRSMNQ EKAGLTLTDS AREELYPDLG ERKGDDVPDL GPVDNSTGGV
DAPVVKSAVV PTLRNDVISP SADSTSKKAK KKKVVLSTAA APAKSSLFSP ASAELRAPAA
PSTDENDASS TKPAVIDEKV SSESAMMAKL LALRAKNEAK RRLKAEGGNP AAPVRAVVDK
YDALPKYTPQ ALHLHTTHEM LALAKTVAPL QLQQKVVVHR LDAIQLGRMQ LPVCNAEQEI
MEAIQNNSVV ILCGETGSGK TTQVPQFLYE AGYGTDGMHP GMIGVTQPRR VAAVSTAQRV
ATELNVDFGQ RGAVGYQIRY DNEHVGDATR IKFMTDGILL KEIQQDFLLK KYSIILLDEA
HERNVNTDIL IGLLSRVAPF RAQMAIEERE HFDSLSLADQ ASAPPPIQPL KLVIMSATLR
VEDFTQNKTL FPTPPPVIKV EARQYPVTVH FNKHTELHDY VQAAYQKVAK IHRRLPEGAI
LVFLTGQREI LQLVRQLRRT MGSSQRKKLV QASTHRRNSV QNEAWYIREH DDDDDEADLD
DADVYGDEEE VDDDKSDDGD RDGDLDGDAN AIDEADDLFP FVHVLPLYSM LANDDQMKVF
EAPPPKHRLV IVATNVAETS LTIPGVRYVV DAGRTKERVF DLKSGISQFQ VQWISKASAD
QRAGRAGRTG PGHCYRLYSS AVFDNEFKTF SPPQILCQPI EDVVLQMKAM GIENILQFPF
PTPPEAIALH AAVTTLLHLG ALDRTTNSIT GLGKTLAGFP VAPRFAKMLL LAQQVGCLEY
AIAVVASLSG QSPFILERER KETQKFQKED ATNDTLPTDA STAADTETRI DAWTEELQEA
EAMKRHTQWI DNDSDVLSML RAAGAYAYSG GSTSFCAENH LHEKIMEQML KLRGQLTTIV
NKLVGATALT LRPNMPPPSD DDQDLLRQII AAGFVDQVAR RVPAGTITSG SKIERNCAYM
SCNDVVTEPL YIHPHSHLFT TDPSKLPPYV VYTNVVRTSR AYMKTVTAVE PDWLFSVAAN
TPLCETSDPL AAPPPKYNAA LDRVECYVKP MYGSHKWELP AALVEYPDGP VKLRWFGRFL
LDGLVVPSLK PFLANKLREP SLSLIKKKFD VKIQVLVSAL ERAKVSSRRA LVAQWQRNPK
FLHDELLSWV QDNHKAALKA QWKAIVTREA L
//
