ID   A0A024UEL8_9STRA        Unreviewed;       602 AA.
AC   A0A024UEL8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN   ORFNames=H310_04626 {ECO:0000313|EMBL:ETW04322.1};
OS   Aphanomyces invadans.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Aphanomyces.
OX   NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW04322.1};
RN   [1] {ECO:0000313|EMBL:ETW04322.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NJM9701 {ECO:0000313|EMBL:ETW04322.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- SIMILARITY: Belongs to the helicase family.
CC       {ECO:0000256|RuleBase:RU363044}.
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DR   EMBL; KI913958; ETW04322.1; -; Genomic_DNA.
DR   RefSeq; XP_008867278.1; XM_008869056.1.
DR   AlphaFoldDB; A0A024UEL8; -.
DR   STRING; 157072.A0A024UEL8; -.
DR   EnsemblFungi; H310_04626-t26_4; H310_04626-t26_4-p1; H310_04626.
DR   EnsemblProtists; ETW04322; ETW04322; H310_04626.
DR   GeneID; 20081676; -.
DR   VEuPathDB; FungiDB:H310_04626; -.
DR   eggNOG; KOG0987; Eukaryota.
DR   OrthoDB; 5474774at2759; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   CDD; cd18037; DEXSc_Pif1_like; 1.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR010285; DNA_helicase_pif1-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049163; Pif1-like_2B_dom.
DR   PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR   PANTHER; PTHR47642:SF5; ATP-DEPENDENT DNA HELICASE; 1.
DR   Pfam; PF05970; PIF1; 1.
DR   Pfam; PF21530; Pif1_2B_dom; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU363044};
KW   DNA damage {ECO:0000256|RuleBase:RU363044};
KW   DNA recombination {ECO:0000256|RuleBase:RU363044};
KW   DNA repair {ECO:0000256|RuleBase:RU363044};
KW   Helicase {ECO:0000256|RuleBase:RU363044};
KW   Hydrolase {ECO:0000256|RuleBase:RU363044};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363044}.
FT   DOMAIN          455..493
FT                   /note="DNA helicase Pif1-like 2B"
FT                   /evidence="ECO:0000259|Pfam:PF21530"
FT   REGION          133..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  67159 MW;  63873D5835492DDE CRC64;
     MSEGIRCDVE IQVALTATGQ NSRTKLIRNA RLCQRKGGLQ LFGEHYKTAI RTHGVELYFS
     HVLRGKLTFI WRETLRYTQY NCHNGAPNEM LQLKEFALTQ GAIAKSPLPI LPTASSVTRP
     PLQDRTNVAT TLVPVSPPSK RRQRTSPAKA RQHASQYLTA IPKRNRVLTP QQAQVVAAIQ
     RNENVFFTGR AGTGKSFLLG HIQRVVPPTG LYLTATTGIA AFHIHGMTLH HFAGLTAMDK
     LHVPTMLATI QRNKDALFRW THARTLVVDE ISMLDGRMFE ALEAIARQLR QSTRFFGGIQ
     LIVSGDFYQL PPVAQDRQPR FCFEVAAWQR GMTISICLDQ VFRQRDADFV DILNAIRVGT
     HTSAMLAKLN QRMGLPTADA IHIFSHNEDV FAMNEARLTA LQGKAHEYAA IDTGDRELLK
     GSPISARIQL KSTVPPRVIE CDGYDQRYPV NCMIECLCLR RLWMVEGVIV MLTKSLSVVN
     GLVNGARGTV LGFTRDTHMP IVRFDHGISQ PMVPETFPIM ANHTVVAVRQ QLPLTLAYAI
     SIHKSQGLTF DRAVLHLGKV FEYGQAYVAL SRLSSLRGLT LATPVTHSTI RVHPRVRDGM
     TS
//