ID A0A024UGW6_9STRA Unreviewed; 1499 AA.
AC A0A024UGW6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RNase III domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=H310_03284 {ECO:0000313|EMBL:ETW05529.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW05529.1};
RN [1] {ECO:0000313|EMBL:ETW05529.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW05529.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI913956; ETW05529.1; -; Genomic_DNA.
DR RefSeq; XP_008865306.1; XM_008867084.1.
DR STRING; 157072.A0A024UGW6; -.
DR EnsemblFungi; H310_03284-t26_1; H310_03284-t26_1-p1; H310_03284.
DR EnsemblProtists; ETW05529; ETW05529; H310_03284.
DR GeneID; 20080334; -.
DR VEuPathDB; FungiDB:H310_03284; -.
DR eggNOG; KOG0701; Eukaryota.
DR OrthoDB; 53947at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 565..680
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 1025..1142
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1206..1364
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 1453..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 167413 MW; F62774EB12335BAE CRC64;
MSLGEHQKEM VALARQQNVV VSGKSGIGKT FAAAFFIREM LLDHPESKAL VLVTSVAKTT
EVFKLVSRLC SEKVAVASED VAHLWQDAAH SKRECAQARV LCVSPSIASH LFYLGHISLE
TLALIVVEDM EDMFATAATF TERLATKYIK VPHLQRPRLF AMVSKPLSEL DLPTSRNPLY
KLVTAFCISQ PTFRKRATIA PIIVETFQYE SSNYADAIGH PVDFLRGANP LHCNAEALYA
SLLTLGNVSS QYDVLTIESR RKRFVTAAEA ILEQLGLWCF LKFIELELRH ELKDTLDRQI
DNGMDAQAIN ILTTMDVVPP VMDPKSRIEH HADVQQTQTF LAWIVEQQHK HGLGATNARL
KKVADLYGSY MDNARETGRC WVFLQRRVHT RVVAEYMTAC FPAYPPCCSM LGSGHGSVAG
LDKSDVKAAD VEKLFNEGKS PLLVTTAMST EVEHIAPCDL VICMDEVVDP HKLVDFRQRA
DPDHGVFKYV IPDTPMELDK YRALFGKMAM LLSLDGNGAS TTETLDQAVV PRRNTQQHGR
KHHHGRVKYE LYHADVKAKM TLENSIQILT AFCHTLPGIK IYDNRPLYMI QRHLMGRLDG
RKRCRTDTAD DGTIDHRKFL FSASLKLPSM LRVKHNISTP KVASDKQAKC IAAFKAVELL
LKRGFLDRSF KSKLLVNRTF IPQESVDEDM ELETQNSYDI PPATAVEMGL SPVKSKLLRD
GDDNDDAVMH LYGLQGMQYG ILCTEPIYGG KTSGRWRFEL PTSDVMKPAV QHVPLTVHPT
KVTLRQSDLK MALKFHVMLM RLICYGLEAA MSPTNGDIDT EFSSKNDKGY VVVPTLCPVG
GGCLEIDWAG LHNVMQSALL RPAWPMSGEC GNCIYVSNKR RNVAYVIKKV TTTMVGDVAR
RVVSNDQYWS YTLRRAKSAP GIPILGRWYT KEALLTASPD QPLVHAIEIP GAVPLIRFVH
EGKAQLDFGE LKERLLIPDQ TSILALTKQQ YFDAIRLVPL LFEFERKCQL STLMHAIGCD
IDAKHMEEAT TKPAYERLET LGDCFLKLES TWWLYQNRHD IKSEGTLSML RGDMIRNDRL
CKLSMQKMLH HYMIYPTDLE QRPFRSWIPS CMGRTPDPVI AHLKWIADVL ESTCGAYIQG
AGEFAGRAFL SWAGCSVCEA PQIYNRTYFP NCIPQHVPAL DSPELPIHLD TWDLTHLGYP
DVPERMYLLQ TSLKYTFQDK RLLLEAITHP SVAQWLIQAD KSTTNVVWKG DYERLEYLGD
ALIEYLVVSY AYVQYPTWQP GALSDWKGAT VCNDALGKAA LICFHMDQIM LTGSMRMDPA
LETKLAHIKR LHAEGSSERP HVTMPKIFAD GFEALCAAVF LDSGCDLHVI RDIFLGPLLS
VIGADAVALV TRKNAPKPAD LCLPRDTPIA FDAHDDDDDD GVAHVVADPA AHEPSVADDA
PVEETVATTA GEAPVAFEAP AAGRTGGDDV VKRARPTPRP IVSSTTPVEI IEIDDSDDD
//
