ID A0A024UHI6_9STRA Unreviewed; 260 AA.
AC A0A024UHI6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Proliferating cell nuclear antigen {ECO:0000256|RuleBase:RU000641};
GN ORFNames=DYB32_003165 {ECO:0000313|EMBL:RHY32368.1}, H310_03529
GN {ECO:0000313|EMBL:ETW05871.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW05871.1};
RN [1] {ECO:0000313|EMBL:ETW05871.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW05871.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RHY32368.1, ECO:0000313|Proteomes:UP000285060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM0002 {ECO:0000313|EMBL:RHY32368.1,
RC ECO:0000313|Proteomes:UP000285060};
RA Minardi D., Oidtmann B., Van Der Giezen M., Studholme D.J.;
RT "Aphanomyces genome sequencing and annotation.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC and is involved in the control of eukaryotic DNA replication by
CC increasing the polymerase's processibility during elongation of the
CC leading strand. {ECO:0000256|RuleBase:RU000641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000641}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|RuleBase:RU003671}.
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DR EMBL; KI913956; ETW05871.1; -; Genomic_DNA.
DR EMBL; QUSY01000141; RHY32368.1; -; Genomic_DNA.
DR RefSeq; XP_008865648.1; XM_008867426.1.
DR AlphaFoldDB; A0A024UHI6; -.
DR STRING; 157072.A0A024UHI6; -.
DR EnsemblFungi; H310_03529-t26_1; H310_03529-t26_1-p1; H310_03529.
DR EnsemblProtists; ETW05871; ETW05871; H310_03529.
DR GeneID; 20080579; -.
DR VEuPathDB; FungiDB:H310_03529; -.
DR eggNOG; KOG1636; Eukaryota.
DR OrthoDB; 118939at2759; -.
DR Proteomes; UP000285060; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
DR PROSITE; PS01251; PCNA_1; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003671};
KW Nucleus {ECO:0000256|RuleBase:RU000641};
KW Reference proteome {ECO:0000313|Proteomes:UP000285060}.
FT DOMAIN 1..124
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 127..254
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 260 AA; 28384 MW; F02BD18CF0E32AB8 CRC64;
MFEARLSQGK IVKLIIEAMK ELISEGNIDC TKSGLALQSM DGSHVSLVSL LLRAEGFEHY
RCDRNISLGI QTASLSKILK CSGNDDALSL SAEDEGDVLN ITFEASSGDR VSDFGLKLMD
IDSEHLGIPS TEYVATVRMP ASEFQRICRD LHTMGDTCTI SVSKEGVKFS VSGDLGNGNI
TLKNNAAAEK EEDRVIIHME EPVELTFALR YLNMFTKATP LSATVTLSMS PGVPVVIEYA
IGEMGYIRYY LAPKVEEDAN
//
