ID A0A024UXE6_9STRA Unreviewed; 2165 AA.
AC A0A024UXE6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=H310_00671 {ECO:0000313|EMBL:ETW10348.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW10348.1};
RN [1] {ECO:0000313|EMBL:ETW10348.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW10348.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI913952; ETW10348.1; -; Genomic_DNA.
DR RefSeq; XP_008861759.1; XM_008863537.1.
DR STRING; 157072.A0A024UXE6; -.
DR EnsemblFungi; H310_00671-t26_1; H310_00671-t26_1-p1; H310_00671.
DR EnsemblProtists; ETW10348; ETW10348; H310_00671.
DR GeneID; 20077721; -.
DR VEuPathDB; FungiDB:H310_00671; -.
DR eggNOG; KOG0206; Eukaryota.
DR eggNOG; KOG1023; Eukaryota.
DR eggNOG; KOG4171; Eukaryota.
DR OrthoDB; 48945at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1060..1081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1285..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1316..1349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1355..1375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1382..1404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1702..1720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1732..1753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1759..1781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1793..1810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1816..1834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1462..1592
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1914..2090
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1102..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2136..2165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1156
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2165 AA; 236439 MW; 03309AF8DDA047A7 CRC64;
MANVERPVLK KNLERLLSSP SESNRVFFVH DRRRVQTHRV HHHVAPYPTN IVRTSKYTAL
TFLPCILLEQ FRRVANVFFL AIAVLQLTTS LSPTHPSSTV LPLGVVLVIT LVREAVDDYK
RHVADTAVNR STTHRLVDTT FVPVAWQSLE VGDIVRVNDG EDLPADLLLM VSGGSSTSDD
TSIESAQSAF VETSSLDGAC LPKRKLCLEG PSTSIAPSIA LETFHGWQIS CDPPNPALDR
MTGSVVNVSS ESSKDTETMF TIDNVLLRGT TLRHTKWVVG IVLAAGHDTK LLQTFRRPMA
NVSQIDRVAN RYICVMIGLL LIVVTASAAA GEDFVQPHKA VRAPFVGDVG SGATMEFATL
WITYLILYSH LVPISLYSTL ELVKWLQTKQ IERDRSLRCP TTVRPASAMT SDLNEHLGLV
NFIFADKTGT LTANEMVLRK TSIAGMIVDH SAPSPHLPNT AASRAFVRCV LLCHSATHQG
EQLDASCPDE MAMLVGFARL NCRFRRRLPH SNVVDIFIFG DVETYSVLAT IPFDSVRRCM
SVLVQRDGED AAIVFFKGAD SALMPLAPPD DTTKAIAHNV HEFASSGLRT LVFASRTVDG
MDVASLTDAA KRRASGDCPD SGKDVLVRGL DGGTPISILG ATGVEDRLQI GVADCLSMLF
RAGMRIWMVT GDKDETAVAV GHSCGLLTTH SNPRPDETPN GPLQQQHVLS VDGTTADECL
DQITQHRRAL KKQGLWNPAT VIPTIAIVLN GFALEAILSA PNEIPTGHLM DLIVQARSVI
ACRLSPVQKA SLVELVKLHH PRNVTLAIGD GGNDVPMIHT AHIGVGLYGN AGLLAARASD
VAIARFQLLL RLLLLHGRWN HRRIMHVVLF TLYKGIALTT TLGLFSFFTG FSGQSLFDSY
LIVGWTVVYT LAPVLVVGVV DQDITAPTIL AYPAIYQEME PINARKVLLW VASAALHSSI
ILYTVAKSIR SSALEAGGVV YVGTVVFAAH LLAATVKAAM TMHRWHRWQP VHVASLMLGP
VLFVLFVAIF SHRYGPWPGL HVARDIAGVG EVMVSDAPTL FLVVFVVVPA SVLPDVAFFG
FQRLYFYSNR HVLQEIDSCL GSTRPRRSGT KTQAVAPCPD TPAPIVLAPD TPATESTSPN
WPASPFPPPE EAPMTSQPVV APPSECAILI ALLQRLHATH RADPEDNVLA ATDTKMHPTK
MEFVGKQRVA LEREFDASAV HHELRRVRVY VYVAACLMLV SLLVEYFVTS VAAHPDTQQL
PLGRVDAPAH VASVRQAVAP TQGRFMTPFL VSRLTIVVLA LAYAQATRTS MFAKHYHVAI
LVPMAVTGVV ISATITVTGY VSAVLFPIVV LTMLHVRFTA ALIVVLVNFA IYLVLQVFGD
DSVLSATELG AFTCYIALVV GLAAHGCWRM QYAMRVDFLQ HRALAMEEFR AVHILRNMFP
PHVMAKLKAG DAIISEEEPD VTVLFCDIVD LHAFMRDHAP AEVVALLDHI YSLFDEMCVR
FGVQKMETVG KTYMACAGMQ SGGVGGQMAA LRAASLAQEM IRLMATCRTP RGTTIPLRIG
LNSGRVLSGL VGRKKQQFSL FGDTVNTASR MQSTGVVGAV QVSEATHHHL KASFSFESRQ
VEVKGKGSMT TYLLGAPMSD ILRELVRPRR DQPPPSNGTG TDRHDVAMKA NVHWLWLHFV
QDGMEAAYIK STAVARDTAA TYTTYALGLY MGFALVRDIV LGFNDARIST AILAFGILSR
AAMVVFTAGM FWWRPASVLA RPCVVASAAM VTMAVYHILA VQTCGVDKQG DMLALDIALV
MFAVSNSGAV VHRTAIWYNL AMWIVSVLVF VLSYRCDNSS ESMHPIILTS CTAIANVTIS
RRIEFFNRRV LWLQRRTQLE TKKADELLYQ RLPEAVVHRM KRGEVVCDEH LMVGILYSDI
KGYTSIASKA NTEQVIHMLD AIFAAFDALT EKHNVFKLQT IGDAYVVVSG LPYVDATVPV
VEAGKDGIPK LLRQDTNPDA AIQEIEQLDQ ARKRTTKTPC VRVDQHLQNL VHLALDMIHQ
VSKVHDPNTN EPLQMRIGIH LGSIYGGVIG NTTLRYDMWG PDALTANEVE SNGVPGKVVV
TAAVKAELDE LGIQCHYHCD IKPNIQTYVV QLEPGQDLAR SDSPRRATSA VGSGGNSPAK
LRKSY
//
