ID A0A024V8T4_PLAFA Unreviewed; 2543 AA.
AC A0A024V8T4;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
GN ORFNames=PFFVO_01760 {ECO:0000313|EMBL:ETW19186.1};
OS Plasmodium falciparum Vietnam Oak-Knoll (FVO).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036723 {ECO:0000313|EMBL:ETW19186.1, ECO:0000313|Proteomes:UP000030690};
RN [1] {ECO:0000313|EMBL:ETW19186.1, ECO:0000313|Proteomes:UP000030690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Vietnam Oak-Knoll (FVO) {ECO:0000313|Proteomes:UP000030690};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Vietnam Oak-Knoll (FVO).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW19186.1, ECO:0000313|Proteomes:UP000030690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Vietnam Oak-Knoll (FVO) {ECO:0000313|Proteomes:UP000030690};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Vietnam Oak-Knoll (FVO).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI925068; ETW19186.1; -; Genomic_DNA.
DR EnsemblProtists; ETW19186; ETW19186; PFFVO_01760.
DR Proteomes; UP000030690; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR11319; G PROTEIN-COUPLED RECEPTOR-RELATED; 1.
DR PANTHER; PTHR11319:SF35; OUTER MEMBRANE PROTEIN PMPC-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR SMART; SM00181; EGF; 4.
DR SMART; SM01411; Ephrin_rec_like; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..2543
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001535752"
FT TRANSMEM 1732..1754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1766..1786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1842..1863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1928..1947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1983..2006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2033..2055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2061..2079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2100..2118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2124..2152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2224..2249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1066..1080
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REGION 2516..2543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2543 AA; 296863 MW; CA24ABB299B7D3AF CRC64;
MRNSDFFFFF FVLLNCFLNI QPYVSNATSN IIKEKNTSFV KKIYDDPYIK KDVTLQLKNA
KYNHINKKIS KSKKNVKKKR GISFVSLNLN KILELQDKNP IKLISNIYAK DKSKFLSTCY
ENNKLNDINN CNRFTISKQI CDTPVGFNLN DNFLVKETGG LSSTCLVDNK PEYWKIYNNH
IIVESGEYFD LKIRNETFLL QTSIIITKDI CMNKTKIESS YFTYQNNHSK IGNPILYKGE
VIGMEIKNIK VKDDVEGLFN VCSCYLDNEH HAYNKCSETN KHYMQISSIR IIKKIVHNIN
ILTGKKLHIN LQNYVTPYPI KSAFIIKKVE HYSCNNINNK SFNEIQEHFY NNEKKLKFYN
IFLYETDLQE FKEDIIFENP GMYLLCYTSN DSQSEYSAEL STILVNGYDI SKMNYLYLDL
YENKLNLRNS VVLHRYNLNE KLEEIFFKKK ETIQCSGEDI IYSNNITETK SYKSDDNSDD
DVIIDTIYIY NINLNAYDQI LEICSKKYNE YSLIGYTTIK PYILHNYKDI NHLTHFNIPP
DHVRTYVVDK KSNILTFFPQ LLNIFNQNDI NDMYMSFSCY SSKNEIIITY SFDKNMTPTF
FKYLKISDAS SSILYITNKG VYLYVLKKKS QLLFLYDITP EKVKKKKKII TNKKINDDYL
ELLLSYYLDY YDFTKCEQCL SPILMEPIYD EKQNLKHIFL ITSHPLAKLL IVGLDFKIIY
KHDNNDVKNV VTTIRGFNFT SDVLKYSSFL ITGISCGILK NESLDCFLID QLNNTIIAIE
YLQKQKTIIL IDSFQGENKN ELNYESINLN DFVFSQSNSY LHTPRNAIAY SFGESYVIFV
NENESNELNL LFYDKNKADN NLSYITKINN TYINDGAIEN IYKFYDHKDL INRNVLLIMK
YYEGDVYFMY IPLRNIANKL ELAYDYPTVI QDNGNTYTMK IKSEEIKKMN ALVNFQIEVH
NVNKSKYVTI DKYDGTIEIK LSEFVGDSVN LTAKLHGFFL ELNVNITFTV ICSNGMKALN
GICIPCPLGS YNNINEYIKN NNIYECTLCH NNSTTKNEGS TSISQCSCLP GYELNNNDLC
VPCKRGTWKT KLSNSPCIFH CYPNSYSLVQ GSRSEEESKC KCKRGFYFVS KDSINFCDNC
NIGYFCPGGY KIGEKKCPKN TTNITQNNFS ISSCKCDVGF EPFDSSNLNA YNFKNDPIFN
DYKDFLDDVK SSQICVPCKE GFYKNTVSEE KCKRCSDNVY TDGLQSTSIS NCKKCEKGYY
LQSEDSCIIC PDNHYCPGAY INDPKYAIYE NQKIPCGDKS LTIPPNNLNV SHLNCLCKKG
FEFIKTDDNE FDCLEVPKNY YKSHLGNKEK EPCPENSVTL YTQTKSKVKC LCMPGYYWDL
KEFKCIKCPK GHYCPGGYLK NCFNNQNLHS CKPQKKKCPL KNSTTQTKES FSQSSCLCDK
GYTINKEELR ECIPCPINTY KDVISNAECT KCLTPYTTDG QIGSTKEEDC TCSGGFFFLN
HCLPCSDKNT YCKGGKMIVN NKNKTIHYGP SKCPPNTTVS FETERPYNKG FCVCQKGFKH
VYTTSDFTKI CAPCERGFFK TIIGDFSCES KCKPNSTSFV GAIHETHCFC LENYYFKNGI
CLNCPDGAYC EGGFQKETLL YMKKNEYYLD TSKIKHIMPV PKENYALYKL KTNIYNTDWF
IVECPIKEAC LYNEKCHESM TNFLCGECKK GYTNNFSKLN LCIKCSGHIM NILHMIFVSI
FILLFTVIMA YLNVFTGANR KSVHSIVIKI AVNYFSCMKI FYVMGISELY FPVTFSSHVN
YILKNIKRLL KAKKNYGLYC ILTNYFDLSH ADAYFYGMVY HAFRPVFLAI ILTLLMFIVV
EIYKYKVRNE TNIKLNITDK IKELGKDKLH EEIMNELPSE RALVLFRYIP IPGDSRFKRI
KNFLEDMIPM YVTLLFFIHT KTTYYMLTLL DCKALYYNDK FVEQYMSYVP SIKCDLSKSY
SKFFILGLTG LIVWGIGIPL MSYLVLYKNR KQLHSENILF KYGFLNNGFN FQFWYWESIV
FLRKILVLLI STVPIFKNAK IFGTTMWLFT IISSIFLTLQ VILQPFDSRN YHILNKLETY
SMVAWTMTLI IFVFLTISNT NVTINFYVLL FLLFFNFVFI AKILISLCYS YIENLRHMKK
RIKLPFLRIF FEKMSKIAEE KDYKDPVVSL NTHDNSIQFT RKYKKKYISC SFKNNMLTTE
EKNYFLDVIS NFIYFGVLNL NFSVFHSYFM EFMLRLSIID NEMLYRKGGN GILKLIAKDP
NKIDKWIKIK EREINKKTFF ERHKKILNLF SKSLFVIQNN IKSIVYKGDK HTIISDYEVL
INVLKYDEDF ITDFKFLYDD NAVKSGLILS DLHLSFTKIK MKDKELIKQL FSLFIAKKNI
VQFERDIQLK NKIEQLTSLY DILIKSSEKK KLTFRKNVED AVKGDPFDYK ILENELKSVN
DRINNLIENY RKLKDVDYFE GMDNIDEEKM DLNNDSEFFN NKLLELSFKE LKDDITENEQ
NEDISKKEKE KIYDETTNDD QTK
//
