ID A0A024VH93_PLAFA Unreviewed; 1441 AA.
AC A0A024VH93;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=PFFCH_04435 {ECO:0000313|EMBL:ETW28084.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW28084.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW28084.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28084.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW28084.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28084.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; KI928027; ETW28084.1; -; Genomic_DNA.
DR EnsemblProtists; ETW28084; ETW28084; PFFCH_04435.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 221..421
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1206..1441
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 76..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..193
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 804..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..999
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1441 AA; 169648 MW; DFF6E27F4F4C0C3D CRC64;
MEDDKDNNIT KENLNEVDIE NSQLPIIEEK NLKEEGVKDE GGKVFLKGEP IHKHLYKHSY
NTQVYKDEVT HMRLRNRENK NLNENNSDDN KKVNKKNGNS NDDIKNNHKY NNDDYHKNMI
KLHCTSPKKK EHSINNNNIV SHNEIEENLK DHTLITNDEE KNIKIIEMYE KKLENEEIKK
QNKEDANENN KSQIRESISK IFKECPTSKP KIINEINNET KYDNNNNNNN NSNNNNKNNN
KNNNKNSSYN NYYYNNIYNC NNMKENNHID GDKNNIYETN NYSDSEKNKS SDTEKNKLKL
NNKNTLKEGS LLRLFRCEYF DTHLHIRYLY DRKEVGVHEY LVNSLYTQRK YEDILFYLPQ
LSQISLVRYE SSSLYRFLLE KASKSMHFAL KLSWLYHSIV EDNSSKYKDL AQRMIQEIEM
AVVNCKPLNN ECKSFEENKQ SYLLDLAYPL LFKRKFILKK IKTNEKLNKI KMYNKCLNNS
YNSYTLKNLH VSNPIEMDTT SFLRNHKNSN DSTLSQGLPN KSSNDDNCNV LKREDHQDVI
NISSEENEER DINKNLKEEV TTLDDNKISR ENNLQNLQSE KKTPILKRKN LKQAHTTPCP
KLPPCYIINS GSLSIARAKV KLPSTYSKLG NPLSFSKFSL PDFNYSYDMI EELQQFFMKQ
RRCDYFSLLN NFINLLISVS NLLAAEPDID LRNELLRRFI YSLNSWMNMR RCIVACCENI
FAMTGLCIPL ESMSSSTFNH DTNNRLSYNN LQILHFNNEE CKIFFSKKRA PYLLMFEVAD
LDEDISHISD NIFYTKKSLF FQQDNNNNNN NDNNNNNNNN NNNNYNCNNN NYNSDVQSKE
PKNVREEYSR KSLILSRNFC CSKNYGYYEE NLNTFDYENR LSLEDKKKKN SKKKKYAKEQ
EQTNNEKLKD KEKERKKKNI FDLNSLKMDD IYVYNCIVND LRRENLISFT SKEDENLALI
KKCLGLKMVE EEKNENDDDD NDDDNDDYNE EEEDDNYEKK NFEEEQKGNY NNDNINHNEK
KKKVPTANDN LSSSSFCVKK NYLLNSRSVS MPSYLNNNLE KCDTSSYDNT SNNIKTSIET
ISNGIDDIQV EKNIEKNETF EEMKRKNSNN EFIDYNEHMV KLSPYYTTTN HRGKNKNDDT
DDNSDDDNIN NYNNNNNSGN NNQDNTISNF PNNILDLSEY FKPENYLNEE FKKKNCKIIK
RLLWGELFEE KKKRIRKVSP YGKLKTWDLK CVIIKGGDDL RQELLASQLI KQFKIIFENA
GLPLWLRPYE ILVTGSNSGI IEYVNDTCSV DSLKRKFGAD SISTIFNIVF SDYIFEAKKN
FIESHAAYSL ISYLLQVKDR HNGNLLLDSD GHLIHIDYGF MLTNSPGNVN FETSPFKLTQ
EYLDIMDGEK SDNYEYFRRL IVSGFLEARK HSEEIILFVE LMMPGYFYIT YEDETKIIFI
T
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