ID A0A024VIB2_PLAFA Unreviewed; 1016 AA.
AC A0A024VIB2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Ribonuclease II/R domain-containing protein {ECO:0000259|SMART:SM00955};
GN ORFNames=PFFCH_04171 {ECO:0000313|EMBL:ETW28262.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW28262.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW28262.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28262.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW28262.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28262.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|RuleBase:RU003901}.
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DR EMBL; KI928025; ETW28262.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024VIB2; -.
DR EnsemblProtists; ETW28262; ETW28262; PFFCH_04171.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT DOMAIN 598..941
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
SQ SEQUENCE 1016 AA; 119433 MW; AC1B634EF12F8A36 CRC64;
MTFLKLTNRK GERHVQKYFY KLNANNRINK IVREVYLRND ISCGIEKCNI CENNKKKLLD
GERSILILDL NTLIKYMDFL YDCDIDNILI PLSIYDYIKS FNKILYKKLR NLCYDVDEES
IIEGSSSSSS FNHNKRFCVF VNTFCKFTYV EDNKDDTNGF NKELQEIIKI VIWLKHHNNK
LNIKVISNNK LLQEDCYNND IPCSTLFEYV NELMKGNDYK KKNKEGKKFN MDTLKMYFEE
DILNEHNDSK ADHTESTCDQ KTYHTLNNLS LNSNNNNNKR PLYEPHLSKS DMIQKLRENK
IIKGVFSVIC VNKLALVKFS DVDEIVIRGT KYMNRAIHND VVAVEIIDEP NEDLYEEDYL
EEQISPEEEE EEEEIEEEVE VEIEEVGEKV KIEINNMNKE KLQNSYIKNE DVKEKENVID
IYNKNNDIVQ KDMINLYEKK MNITYDKQIN ENIYNNINNR HISEKKKLYG KVVGIISRCR
KEYGGIIKEY SNNLNNIKKK LMFFKAFNNK IPYIMIKAQL EDELRNKRVI VTIDNWDIYS
RNPLGRCISV LGNCDDIETE TKLIYNEYNI STREFSENVY KCLPPNNWVI PDEEYEKRND
FRNVLTFSID PPGCQDIDDA LSVEFLQQDG NIEKNYIYRI GVHIADVSYF VKQNSPIDLE
ASKRCTTVYL INQRVDMLPK LLTTNLCSLV EGEERLTYSC IFCFNKDFDI IDISVKKCII
KSNKSFSYEQ AQNVIDDKND QSDTAKSLRL LNKIAKHLKQ KWSNDGALEL RGNTEVLFEF
EANDFSKAKN LKPYVCYETN KLIEAFMLLA NRSVARIIFQ NFKAASVLRR HPPPKHEYLK
ELNDYLKTIQ VFDFKYNTSK DLSHSINNIN LKNDNILSNI LKVMVTKCMN EAVFISGYNV
HNNDMLRHYG LAADIYTFFT SPIRRYADIM VHRILNHIYQ IEELDKKYLD IIYLNKQVAL
LNDKYRNARF ASRASVDFFS YLYIKKIGNQ ITNAVITNLK KNGIQIFLID YFTEGG
//
