ID A0A024VK29_PLAFA Unreviewed; 927 AA.
AC A0A024VK29;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Histidine kinase/HSP90-like ATPase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFFCH_03495 {ECO:0000313|EMBL:ETW29074.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW29074.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW29074.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW29074.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW29074.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW29074.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; KI927999; ETW29074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024VK29; -.
DR SMR; A0A024VK29; -.
DR EnsemblProtists; ETW29074; ETW29074; PFFCH_03495.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR PANTHER; PTHR11528:SF41; HEAT SHOCK PROTEIN 90-6, MITOCHONDRIAL; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT REGION 163..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 927 AA; 106999 MW; A8A40CCB402AAF25 CRC64;
MQNVYVGNKI KFIILYFFCV LFLKDYERSE AFNLARTTEK LNYILNYKTP NRYDLNNNVN
KLFFEKQKKK IEFSRKPLNS FNEDVKTIRE DISSDSSPVE KYNFKAEVNK VMDIIVNSLY
TDKDVFLREL ISNASDACDK KRIILENNKL IKDAEVVTNE EIKNETEKEK TENVNESTDK
KENVEEEKND IKKLIIKIKP DKEKKTLTIT DNGIGMDKSE LINNLGTIAQ SGTAKFLKQI
EEGKADSNLI GQFGVGFYSS FLVSNRVEVY TKKEDQIYRW SSDLKGSFSV NEIKKYDQEY
DDIKGSGTKI ILHLKEECDE YLEDYKLKEL IKKYSEFIKF PIEIWSEKID YERVPDDSVS
LKDGDKMKMK TITKRYHEWE KINVQLPIWK QDEKSLTEND YYSFYKNTFK AYDDPLAYVH
FNVEGQISFN SILYIPGSLP WELSKNMFDE ESRGIRLYVK RVFINDKFSE SIPRWLTFLR
GIVDSENLPL NVGREILQKS KMLSIINKRI VLKSISMMKG LKETGGDKWT KFLNTFGKYL
KIGVVEDKEN QEEIASLVEF YSINSGDKKT DLDSYIENMK EDQKCIYYIS GENKKTAQNS
PSLEKLKALN YDVLFSLEPI DEFCLSSLTV NKYKGYEVLD VNKADLKLKK ENDQNKSDSL
DKQKMEYEIL CRWLHNKFSH KVHEVRISDR LINSPALLVQ GEMGMSPSMQ KYMKQQATAQ
GISENEMFGG QSANQPVLEI NPNHFIIKQL NHLIQIDKMN LQNSEIAEQI FDVASMQGGY
TIDDTGLFAK RVIGMMEKNA EQYLMNVQSN ISNNTLNNNT SGSEMPQNNS PNELQSEMKS
TNGIDDNSNI SENKINESSS NQNNIGENSI AEENNIKNIA ESDVNKINLG ENDVSQNTMH
KQDSGLFNLD PSILNSNMLS GSDKTLL
//
