ID A0A024VPV9_PLAFA Unreviewed; 1429 AA.
AC A0A024VPV9;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFFCH_02070 {ECO:0000313|EMBL:ETW30517.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW30517.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW30517.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW30517.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW30517.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW30517.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927908; ETW30517.1; -; Genomic_DNA.
DR EnsemblProtists; ETW30517; ETW30517; PFFCH_02070.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR48033; RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN; 1.
DR PANTHER; PTHR48033:SF10; RRM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 278..343
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1337..1414
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 380..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..83
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1183..1242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 169886 MW; F2EE2307D444363D CRC64;
MSEFYENDED VLQMIQHIKK ITKESKRKYE LDIDTLVEDT KTNLINNVND EKDNMKQEID
EKIKKLKQEI TKHEKNIKEK NKFNKPKNFV TYADYKYIGK LNNKNEHHGI GIILYNSGES
FYGSFINGKK EGKGIYIDKN LTRYINTWVD NKVFGKVKVV PYNSNRVYYF YYKNYMIEKC
IYFDNNINNK ESHHKNNIYN NYDNNSYNNN SCDDEEKRKY PIGDNVNCEH TDKMNISLHE
KNDKKNEKKN EKKNKKKKLF KYFSNNIENL IIENYQTWSL REVIQWLMLC NVPVKWLISF
YKNNITGDKL KYININTIRN ELGIIAYGHA IKILQLIKNL QVMAYNKKFN NLIQIEEYKN
YIRQKENTNK NIKKGKNIKK EKNKKKEKNI KKEKKKKKKE TKKFNNMDKK YIDLAIHKNV
KNIQNDTFYN KHENIYNCKN QTNFIYQNDS EIKKIMNKKK VSFEYDNNEE KKKKNIIKFI
KNNKSLQNSN GEYYLINHLS KERLPSYEKK LLSSSQSNIE HIKNLPLDVL SNNNSSANIK
IKKSKSKYNN DKKEQKKLPL ILNKSSSEFS PSHSYTSKSY HYNIKPSLQS SSNNSSDSSY
SISSTCSSSS SYVSSLYSNR SNDILNFYRN KIIKYCNNIY MNTKLAYSYM NGFIIPHEDL
IFIHPIENYY MDNTNEKNNI NNPYTKEKIM NHNFSFNTKN NTSFIDINTN IFSSNKQQNI
NNFGKYKKMK SRMFKGKYMG KEVAIKILVG KIKNFKKLHQ ILYNLYNLRH SNLVLIMGVS
IHYPFVFIIY EYMKNKCLFS YLHCIKYKHV YISTFLQRYK TLLHITQQEK IKKTNNINNN
NNINHNNINN NNINHNNINH NNINNNNINN NNINYNKDYN NKKKKEDEQH NIEHQDTFID
LPEKSNISSD DNNSTDISQI QKENFHFLNK KIEENKNIIY DDHTSTLSDH SIHNINKSYD
NVYKNKMNIF HYQHNVLCGA YDNNDNNIND NDIYCNNIYD NNINDNHIYC NNINDNHIYC
NNIYDHHKNT SLNSKEQNTD HNIEQINECN KYASETKYNI KKSNLKNNII SHKNFQKCNQ
IQMNQPYTFP PYQKELSSYL KNEKIKRKRK EMQEEKTKKS LEREEIFKDT NHNEKCINMK
REDYKTNNMY EDTDINNVSN NTFNEISGKE KNQNNIEYNE NVKSHNKTLK LSNEKNNLSS
KEKENILHNG SGEINDYNKM KDKDIPGKDK NGKTDIDNDN NNNNNDKIKS NNILESEINN
IQKNRTDKKK KKNEVNDTIP STSEGENNIN KLNTNKKDTI INNKDEDKKK REPEEKNNDT
FQNEQSVYVD EVIKEYPRIF ATRLPFEASK KDLEKYFSKF GKIVDIYVSR NISNNKNKGF
GFVSFEKQES MNKVLKEKLH IICGKEIVVD VASMRDDKYK HLFQNIKVL
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