ID A0A024VS17_PLAFA Unreviewed; 1929 AA.
AC A0A024VS17;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=PFFCH_01272 {ECO:0000313|EMBL:ETW31252.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW31252.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW31252.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW31252.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW31252.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW31252.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927858; ETW31252.1; -; Genomic_DNA.
DR EnsemblProtists; ETW31252; ETW31252; PFFCH_01272.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR47455; ADENYLYL CYCLASE BETA; 1.
DR PANTHER; PTHR47455:SF1; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT DOMAIN 114..173
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 488..620
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 184..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 50..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 191..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1929 AA; 226806 MW; 4CBBF5F1BAF9B978 CRC64;
MLKNIFSEYL KSYDNKDENY ERINNLSRNY SCDYTSDWRW FSIKCERFLE NELYKKYNKE
EREKKKKNKN IIKENENLAI FRSFFPKILL NIYSKCENPA QFFSNLVIQK FNSVVFFCDA
SGFSNLAEQL DKRINGTELL GNCLNKFFNI LIKIIDYWGG DIIKFSGDAV LVIWPLHNVL
KNKKKKKKKN GTQNNDSDDE HVNLKDNKTS HDSKSNIAQA NNSDDNYPSD YNKKKKNQNA
VEIRKICLLA LGCCMDIHKL LNKFPTPIEN KYLKVHIAIT YGKVSFLQIG NVLRKREYLL
SGKPLEEIGA GESLAKNGES VLSYSFYKNI KDKVMVQGTC KKNFFLFVKM KEEIDMKKEE
QNEREEQNER EEQNEREEQN KTEEQNKTEE QNKTEEQNKT EEQNKEGQLP NLLVDNRSVV
KEEENISKNN IKDNKRRNSL EDKIKKRFTL LSTDKQSRQS TIIYENFDLL LKTFIPDIVY
RKLSLGCNIF FNEIRKVTII FVSVKDIDAS TMTGVHSAHG IMKLTQKAVF TMEGTINKFI
LDDKGILILI MFGLPPLYHC DDTIRALLTC FRLIDALKSL KLNGSIGIST GKIWCGIIGN
KIRKEYTALG DSVNVAARLC FKAGNKEIYV DENTYNNCKH FISFQKLISI KVKGKNKLIK
IYSPIGTINK KSIDYVYDNT SNDNNYFTDE ELLVNNQNNK KNNNILLNKE ETIKNVHENL
YTNIDLSIIQ NKLIKTNYQQ IFDFSFLNNN FLFIYYKSFF KNKIYHLFKE KNSFYYLQNL
DTNNYKIITT TTFPNYSLNK NIEQINNNHL IIKKDMDKQY VNNHQNLNHT IKQNQFILHK
DGNHINSYDD FHGKSHSPSK SFSSINNTYN NLLTYDMIYS LSRFNKIKTS LHVDYKSYTG
PFLLHEYYDP FHFKFKELSR IGGVLFVEGN ENLGIFEFIK LITNGLYNFK LFNVSNMPNS
LYINITNPLL PWKILCNDIL NTWKLSHMRK KNLLLNKNDN FNMLREITHP SYHWFFKSMI
HNISFITPDE KKRKTKKRAK RKLKKKKKLS KMVSTSVIRM IWMQYITALR MCHMAALGIS
NKNKLTNKHE PSYPKHTATG DVSSSSHAYS RNDIQTKMKN ELKENRIGII SSMIYYFTLH
ENMFIIFNYR SGTSLNINIE DDAWKISNNI AKLAMLKRKK ISKHLQKNLK DWRKNHSRKC
DFCKGNFMNT TYVNNVHENN KCADNIYGNI TNLNNIYGDN TNDSFLHNND DDDNMYNSDK
QNRLSFKKNI NDFLDDHMRA QSIDHVDKNI ISQIHNDINN DTNTNNIYNI NDMYNEENSH
YSQNINITND NNNNNNKKNS SSSSNNNNNN NNISAFSLKQ QKLYQAHEII LMDENNDSSS
KKSSSATLIN NSEINSQIYN NENIIHNTNK QENINVLQLF KEEKDIVNNT NKIKEQKMFY
KTLCPNIKDN ILLYIAQQKM NEQNNNYQMN KNQNSKNNYL NDNIQNQINH LVKDNMDKHI
YNNNNNNNDN VYQNKSPLCN PFFMHKHKPL IFLFINGMKN NSNIKQLKKI KKYAQQCEAS
IELKPFNKYD LYEFVSLCLN IHKDKISTQL IEYLNKTCFG IPKFVQYTLF YLLTNHYIEL
YKYEKDKNDK HNYENNDELH PSNNEKNNEQ NNEQKNEQKN EQKNQQNNEQ TNQHNNDEIF
FLKEQKYEKD SSSTNPAKIN HPNDITCANQ FNQINNINQN YDKNNYINHF SKQIISVQNE
TVKSSVFPSN STTSCNDNSN NDDINYEYDL VVVKDLNEAP LVPRLTAYCM SLIDSLNQEE
QLLAKLCSFF NNTFNIKKME CIYPKYISRC ELKKIIVKLV EKNVFCLYED PNKKSVTLPK
DNVNSIHNIN FVYRDMYNKI NSFLEKKSKH HSLFGKHKNV PDEEIYFCIT NFSLKKVITI
KRKKRNNGK
//
