ID A0A024VTW6_PLAFA Unreviewed; 2429 AA.
AC A0A024VTW6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=histidinol-phosphate transaminase {ECO:0000256|ARBA:ARBA00012748};
DE EC=2.6.1.9 {ECO:0000256|ARBA:ARBA00012748};
GN ORFNames=PFFCH_00360 {ECO:0000313|EMBL:ETW32194.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW32194.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW32194.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW32194.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW32194.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW32194.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC ChEBI:CHEBI:57980; EC=2.6.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001045};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KI927809; ETW32194.1; -; Genomic_DNA.
DR EnsemblProtists; ETW32194; ETW32194; PFFCH_00360.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR42885:SF2; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42885; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED; 1.
DR Pfam; PF01276; OKR_DC_1; 2.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT DOMAIN 580..805
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 854..943
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT REGION 378..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1038
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2429 AA; 282379 MW; 08E8261026B05106 CRC64;
MKLSNDPNFQ IDEDSLHMNN IDQNKIEEDV IPDSKAVSDY NVNNQEVQRK SLSLKEDEKM
RINSVGVYKV KREEYKNNMH PRNVQQKNIN QMYKQYKNIN TKVYDENIEY HRKNYEENLY
GSTKYDRIEE LENYININNV TSVCSLRIKL WEALLLYVNN LNVEFIYFII SCLKEIEVYW
GQEATENLHE IINLINDKKY KEVSNKIRET LSSLSVTTGK ITDENPFFYT LIVSSKRDEN
RSNSTNNYSD LTCELNKILQ YEHNRLSNQI NNKTLEYKII EVSNAREALL ACLINPQILS
VVIVDNLNID EERVEEKDIY NYYNDENNSV RNHSVANSYV YNSSIVNNVH MPINKSNMNN
IALNALALNN KDIYMKGMMG TSRHHNNNNN NNNNNNNNNN NNNNNNNNNN NNNSGVNDFR
KNKSYNYSNN YINNNMNLNK YNDSNKKNII NNVNNLNNMY NLNNMYNMYN MCNINYNNDN
ICHHQFKEYK FNIADFVLGY VQLVSAPLEK MKKGFNSLVI LIKSIAYIRS SVDIFCVCTS
ITLDSLQSVN NMIIRIFTTH DDHSDLHESI LDGVKKKIKT PFFNALKAYA ERPIGVFHAL
AISKGNSVRR SRWIQSLLDF YGVNLFKAES SATCGGLDSL LDPHGSLKDA QIMAARAYSS
KYCFFVTNGT SSSNKIVMQA LVKPGDIILV DRACHKSHHY GFVLSQAFPC YLDPYPVSKY
GIYGAVPIYV IKKTLLEYRK SNKLHLVRLI ILTNCTFDGI VYNVKRVMEE CLSIKPDLIF
LFDEAWFAYA CFHPILKFRT AMTVAEKMRS TEQKRIYEKI HKKLLKKFGN VKSLNDVPEE
ELLKTRLYPN PNEYKVRVYA TQSIHKSLTS LRQGSVILIS DDNFESHAYT PFKEAYYTHM
STSPNYQILA TLDAGRAQME LEGYGLVEKQ TEAAFLIRKE LSEDPIISKY FRILNADDLI
PDRLRQCTVS YMKRKHVNNN NNKKKNNGDD DDNDDDNNND DNNNNDDDNN NDDDNNNDDD
NNNDDNNNND DDNNNDDDNN NNNDINHDNN HNNHNNVGNQ KKYNNSLNSR CSADEDATGS
YIFNNNIKEI EDNTESAHKI PIEYVDGKLF NVIKYPHEYM SEDNSPNNIH TNLQKSNMKL
LNDNNIEVGR ILESSNCFKY SHNVNMCNVL INNSSYRNNS DNKKDGSEKR YVYDEYNESV
KEYSPNDDTN YDATYKGYVN GHVNVNMNNL MNGDNKCDWY DTNDCDDNKN IYCDKANNIY
YYGNNYKSKE EKRKKANYGS VNSICCDSTY CMDTSDDNLS SNECSSYIDN NNNNNINNNS
NNNNSCSGDM KNFLEYFERS WLSEDEFVLD PTRITLFTGY SGIDGDTFKV KWLMDKYGIQ
INKTSINSVL FQTNIGTTGS SCLFLKSCLS LISQELDQKK SLFNERDLNQ FNESVYNLVY
NYIDLSVFSA FHPLFKKRYE DKNIFNNEGD LRKAFYLAYE EDYVEYILLN NLKDRIRHKE
MIVAASFIIP YPPGFPVLVP GQIISEEIVN YLSGLSVKEI HGYDENIGFR CFYNFILDYY
ETININDPYS MYQPMDKRLY EQLKEKYLHS KKDLHDHRLS NLYMYDKETM KMKKVYIHNN
GSYSVDPYGY ISDLNEEEGV IINAQHVNNK KDIFFHNKRE NKIHNNNNNN NNKKKTHVNN
KSDVMIIIPS EDHLNPHIIH KMSDNNRKII NTKNYNNIIN YTSNILNNKQ DHAFYNSGSP
RTSVCSNHKN INTNGMFNNL MHKNDERGNN KSMSKHEKNN HSLYLTNGVN TKSHKKMYIE
SYNPKGDREL DFQNKSTMYN NMDDVAYHGK HYHSVKKDII NNDTSLKENR YNKNIMSCKT
NNNTGTNSKN ERKKKKSFGI HMSLSPNNNH LKGHDTSRYS DSTSICEDNI NDDNIDDTGH
KKMDAIDGHN IRNKKSDIKE ILYNNNDNDI YGNACDVIAC KENMYINEKD SYSDVVLIKR
NNKINKNDGN YYYHNNFSNN SKHSNVVPIL NKGNVLLNNT NVKKNDYCVI QKDNKIMSRN
NMNTKYASSN EYNKKKEEGA YYSDSSKNIH DNLFLKRKEN ENIEHITKDV MKKPLIGYNK
EEIKKINEFL KINRRIADEH MGDIQIKLDE EILERKEEDM YDNKNDMFNV NIKSNIEDVA
DNSPQMNIDK KDIIVLASNN NYCDINNNNN NNNNNNNNNN NNNNCNYVKK CETNKCDIYI
TKDNLEEIQK TNMNIKKDVE HDIGEYNFDS VINQSVNNNI NILIDKYNCN NIKKLNNSNI
CENNNLLSND NNYIVNHKVY SSIENTNTLN CNNIKTDNNS NNNNNNNMPY KENKVRGLII
CENDINKNTG RQLNTLNNNS YINNLITNVD DDTFVHREGN FFLQCEFTNS DINCNMYEME
TSLNNICTNL GGVIIKNNME YDDCETKHK
//
