ID A0A024W0M1_PLAFA Unreviewed; 1034 AA.
AC A0A024W0M1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFTANZ_05151 {ECO:0000313|EMBL:ETW34108.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW34108.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW34108.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW34108.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI926536; ETW34108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024W0M1; -.
DR EnsemblProtists; ETW34108; ETW34108; PFTANZ_05151.
DR eggNOG; KOG0345; Eukaryota.
DR eggNOG; KOG0348; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR025313; DUF4217.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF13959; DUF4217; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01178; DUF4217; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 40..232
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 267..436
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 561..721
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 239..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 124037 MW; 389EF5530D67C4F5 CRC64;
MNEEEKKKYP FDELKLDESI IFSLYIQKYF YCANIQKKTI PPLIKKENVL LHSQTGSGKT
LCFVIPILQY LIHHRNKLCP NDEKFIKRND LFNKKNVNDT VSYNKDQIER IYETVENINI
EKKNAYRDVN VNIDIRNFLL YTHNMLRNTN EEDISKKVEI NQNDNKVMTY KDKIISDDQV
NIIKKDEINI QKNNNQEEII RKNDLQNITF ATTCNSNYQD DKQETNKEKH EQKIEEKYNE
QNIQTNNQTK KPHNNNNNNN NSKKKTQKLL NIQAIIITPT RELCIQIYNL INKFLFFLRF
YISHTLNNNM DNNVLTKENF FINCLLFRGA VKISEDIKII ENEILKNNRY QIIISTPGKL
SSLLSEYNNK YFNTNELKYF VLDEGDKLLE DSYIRYMENI IKNIQAYDYT TCICSATCLQ
EENVYNLFQV KKKNFIKCIN TNNQDNSSTV INTYQMPDRI QNYYIILRNI DKALFLFKFL
NTMVNDNETV IVFFPTCLCV EFFFHLFKNI FNTKKINKQN ESKNKKNKNK IYKGIHNDNV
DNINVDNISV DNINVDNHID YIFQLNSKYN NIFSDADMAN FVKLICYMNK YIGEKKNNFN
FLKIHRKMKD KKRVATYNKI INTCVSNKGT KKKENRNINS ERKIIFCTDI ISRGINMDIH
WVINYDAANK NMTYIHRSGR TGRFDKTGKN IILLNKEEKE YIYFLKNKNV HVVNFKKTDM
FQHMINYEKT LLKSEHIINN DALRIIEINH NEKKKNNITI NKNSFFNLYP QILYDKKLIG
KHQNGDLQIQ KGEHKKNKNN LLILNKKLVM FFLKYITFFV IENREIYLLS TKAFLSYIEF
YKNHQLKFIF SFNKLNLTHL CYAFSLIKIP KFKEKSKIKN FQNINIQSFQ IPYKNEEKEK
KRQEHLKEKQ IDIITQEQKK ENQIKMQKKK KRKTIVQRKH EQRELEENEI DSLFYEENLY
KKLKKKKITK DEYDRLLNMD DIDKMFSSTS KTSKCTNLTN NTHFFKSNRK KSKKRMKTYN
IKIKKNKRKK KKRS
//
