ID A0A024W418_PLAFA Unreviewed; 1555 AA.
AC A0A024W418;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN ORFNames=PFTANZ_03826 {ECO:0000313|EMBL:ETW35407.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW35407.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW35407.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW35407.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
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DR EMBL; KI926474; ETW35407.1; -; Genomic_DNA.
DR EnsemblProtists; ETW35407; ETW35407; PFTANZ_03826.
DR eggNOG; KOG0206; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF214; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708};
KW Translocase {ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 478..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1148..1168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1273..1294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1306..1326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1356..1381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1393..1414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1426..1449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1455..1477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 24..85
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 1243..1492
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT REGION 339..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1555 AA; 179119 MW; C3F19031C11CCB58 CRC64;
MSLVYRKTLN FLKGKNEDDK DVKININGEN KRTCNNSVIT SKYTVFNFIF LNMYEQFHKI
SNVYFFFIGI LQVIPQFTAT NGIPTVFFPL LIVLTANAIK DAFEDWNRHK TDKIENNRMC
YGIVSEEEKK IYQEKSNKKN IFKKLKRYFF GNRKICNTEN YYDEDDMCDD EITDINDYIN
NYEDNLENIE GTVKKRWKDI KAGDIILCRR SEFFCADILL LCTSHKNGIA FVETSSLDGE
TNLKVKEANT FLFNILGNDR NSAIDNVKNL KGFILSDKPN KDLSTMYGTI YFEKDKKIDV
ENIGIQELLK KTTEEIEYRK KRLSSVDLSK SSSAIGSNLC NNNNKSDSKS DIKNYNKDDD
DFDDMDENNI LKNDNYIRIP FDEKQFVLRG CKLKNTDWIM GIVIYVGRET KIQMNSSKSI
KKTSKLEILT NKMTIIIWVI QMIICLISAY YNAIIVSSSR KNRFRYLPFN LEKAKKPYIV
GIISFFSWVV ITGNFVPISL IVTMSFVKVV QAYFISCDKN MIHKVQADVP SFGEQKEIPN
IPKDDISSDA DVIKRMRTKK IADSSLLHID ENQTEEDNMD MKSDCIAFKN NSSHQNINGN
NKQYSSSSLG IISNAPKREI SSRVISFKDS KEKNYIYFNA VPRTSSLIEE LGQIEYIFSD
KTGTLTCNIM EFRKCAINGI SYGKGLTEIK RNILKKKNLE IPVEPTMKFK KKTPHVNIID
NDIINHLKDP NHFNHVNLIN FFLHLAINHA VICEKDKEGV TTYSSSSPDE EALVNAAKHF
DITFLYRREG KYGISIFGKI YEIDTLATIE FTSKRKMSSV ICRIPVINPD YNHPTDAKSS
NMDKKKNNMD DHLVVGKNEE KEETVDLNVY PPKKEAHSKL NNNNNNNNNN NIRIDNLYDD
KNNFNIIYNH NEGRTPEVIT CKNSKNSKIM LFCKGAGSII LKKLAKRTDV DEITIEHMET
YADEGLRTLC IAQRELSEES FAEWYHLYKE ASLSIKDREE KLESVAEYIE NDLILQGITG
IEDKLQEGVS STIEDLRMAG IHIWMLTGDK IETAMNIGIA ANLIDNYSEQ FIYTEEYIES
EEALIKKIDD DILMVEKSLN IPHYNFDDEN NNVEDEKRKT FFRNNFIKNF FCAKNKSGLL
LNPDKYNMLI NTLNYVLVVD GSVIDLLLSE KMERKFFYLA DKCSSVICGR VSPYQKGAIV
SSANRLLNKI TLAIGDGAND RNMINTANIG IGIRGQEGVQ AFNSSDYGIS QFRFLKNLLL
VHGRLSYRRI SKLVVYMFYK NMVLIFPLFI FGSISLYSGQ KIYFEFLLHL FNVLFTAIPV
VIHAVLDQDI SLNTAMEKPN LYKLGIHHYY FNIRTFISWV MNSLFHGSVV FLIPLYFLSY
YNIPTSDGIP YDIWTVGCAT YFLTVLIVNF KILFETYYLN ILPISGIALS IFSFVLLVTA
FSFMCVGSIH LLGTIVYLVQ SLRFWLVVIL GLFTALLRDY VFKVYKRNFN PEIYHLLLDQ
ENAKIGMNDV IDQLKLNEFD KDDDIRIEKS KSLGYAFSEA DPACIQLIRK QDNMI
//
