ID A0A024WA56_PLAFA Unreviewed; 1031 AA.
AC A0A024WA56;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Actin-related protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFTANZ_01865 {ECO:0000313|EMBL:ETW37428.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW37428.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW37428.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW37428.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001836};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the actin family.
CC {ECO:0000256|ARBA:ARBA00006752, ECO:0000256|RuleBase:RU000487}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI926363; ETW37428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024WA56; -.
DR EnsemblProtists; ETW37428; ETW37428; PFTANZ_01865.
DR eggNOG; KOG0680; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF387; ACTIN; 1.
DR Pfam; PF00022; Actin; 2.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708}.
FT REGION 580..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 121000 MW; 91246ED5457385F8 CRC64;
MSAPVNIDIP KLILDNGAGL IKGGILPSYS QIEGSLCEEI EPKFILPNCV GQIRKKNIFH
ISDSCQSICE YFCHRPHVDG LLLDLELETK IWEKIFSCRN TVGGKINEMG LCVTESYLTP
AYIKQGVIEL LFEYFNMNQI VIVSSQTMLP FSYIGLNLGQ YDILNPPIYR SRSSITKKVD
QVIKRRRRSE NCDIDMNKLD SSKDNMMENN LVTDSVINIK KLGSMDKTNE ENVNSMNSVN
NVNNFIDDNS YESKKIRLSQ ESVDHNKFNE NKGDPINIQK DNVFAQDDDK NIEDVEKYEN
SGHTFEKRRY NKKNTKSDVN IFTNKHIYLK NIECYNKYSH KLYIDDKYQG DNWEDFYFNS
FFNLNNYNNN NIYDDDNNNN NYLFEGLKTH AKSYKFNNNN VVRTLYDNNY LGKNFSRQDP
NFIIPEKVDL YRNYYGKNFQ DIKMFKKNYR NKYINNFYKN IINGNYNLSL RNPCALYIDV
GFSHTYVLPY IEYKLIEYAV LRTKISGSIL NSYLKSTLSY KHVNLEHNEL LVENIKERAC
YVSLDYLKEL EKEKTRLENI KNQRIKDKLD MRAEILMKEL EEEAQGKGER DKEKKKEMDT
NMEKKKMKKK QKKKESDLLT NSLVKEDESN STINDMKVNE KDNSDVTEYK ENSSNSYDKK
MNNILTKKKN DSCGSSLSVS NKSDDDMYIK KRRTCNVEEG GVDITEDQSY MSDLKSNVSV
DKSRKSSRSN INVDKSYTND EDNKSNYNNN SDDNNNNSDD NNKYSDDNNK YSDDSNEYSD
DSNNNNNNNN KYSDDSNKYS DDNNKYNIDK CNGRKNKKLQ PHLSYQYKLI DYNNVSKRQI
NKVFNTLKSN YNNNCIYIDS DYDYKEEFSN FIIDDKDDNM NIKDMSIKVG DSSKGKEDVI
NLTNERIGIP EILFNPQDIN LEHCSIVELV YRCISLLPKH IQKYFVSQIY ISGGSTKFRN
FKHRLYKELR QVFPSDWDIN IYSHKNSLYS NYIGTYVWLS DPSIYNYNVI TREQYFNFGK
ESKVWNRKKD A
//
