ID A0A024WBK1_PLAFA Unreviewed; 1214 AA.
AC A0A024WBK1;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Rad50/SbcC-type AAA domain-containing protein {ECO:0000259|Pfam:PF13476};
GN ORFNames=PFTANZ_01354 {ECO:0000313|EMBL:ETW37923.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW37923.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW37923.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW37923.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; KI926336; ETW37923.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024WBK1; -.
DR EnsemblProtists; ETW37923; ETW37923; PFTANZ_01354.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..240
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 535..562
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1214 AA; 145851 MW; EEBDA00AB934EB98 CRC64;
MTTLEKIGIQ GIRSYNDEDV EILEFATPIT IIYGNNGSGK STIIECLKVS CTGDFPPNAE
KGKSFLHDPL ISNKMNIRGK IDVLLNNYNN KRIGISRSYN LFYSKDKNKK VKHTFRALDN
NIIIKKEKGD DLIITNKCVD INNHIPKLMG VSKALLENVI FCHHDENLWP FSESIKIKKK
FDELFGDDHF SKILEELLKC KKYLNDLLKR KEFDLIHIKE NFEKKKNIYI EIEKNEKEIQ
SAQICIQLDV EEIEENTIIL NNLIKKKNLL YKLIGNIDSY FLLYTKFKVD AEAYKDLKEV
YEENYTELLY FQEVFNNDIN KCEICIQKVK QDIQNLQHEK DTCMFNYNES NKYDDNYELS
KKQLNEYIIK RDDIRNKLKD IFFYNDQIFF SNYKGNSSSD MIKHSSINEG HQKEKLKKKF
KKHDSVYIKD HLLKEYENLL HMYDIHKEDI ALYNHDVMLS YKNEEHIPSN ARLMEELFLI
CQNKKHEKKI NSIRYILKRH ISHIKRNKYK KRNVIYKIKN YKKRLLKIEK NITLLDIYKN
KLNKLKSNEI IYEQNLKKIE KLNQLKCLYD NLTTLDNEMD TYNIQKENNY YEEQIEKNMK
QINDIQKLKI WIHTFCNIIR NYNIFYEFIQ RCKKIHEHCV IFFDILFSLL DVIKTDFYKI
VDMLKERDMD FNIEIEESVE KIKDNKINEC DVNVDTLNKT NSIHHVNNIK INSKSLVCMN
EHLQRKRENE KLNDYTCKLK KQKTHLDISI LKNRKYLDIL LNIINIFIDK YENKINNIKT
LIIPLNQKVL EISKKLNNMN NNINEYKNYL SNFIHMLKEK KYKDVKDFVN YVEAIDNQIK
IKKKNLWMLN GKEDLMNEFK NHLKSDEQNN SDNNKKVGVE KKKKKNCLFC KNTISQNNKD
IVQIEMYIEE QKRDMLKKIE ESEKDINILK NKKEENIILL NYYYYHIKHI HTYTNDSNEM
IVKLKEELLS AQDSIEKYNI KIKNIHRKFQ LVQKFKETCV YLINIQKDIL DVEKYIKDES
IKIKGNFQEM KNKIKDNVEN NKMSNNTNKC NDTKTCNNTK TCNNTYTCDH LFIEKLYHMI
ENLDISIEVK ESNLLKNIKE FVKKFAKYNN KDIINIFYNK ICTSNVNDSY SYIPYNDIIN
VDLYQQYNYQ NNYKDRFKYN LYKINNANYI CKLLSPHQKV SLKDCYSSDQ TPQKIYVDEE
KEKEKKKKKK KKNR
//
