ID A0A024WBS5_PLAFA Unreviewed; 967 AA.
AC A0A024WBS5;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=PFTANZ_01617 {ECO:0000313|EMBL:ETW37691.1};
OS Plasmodium falciparum Tanzania (2000708).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036725 {ECO:0000313|EMBL:ETW37691.1, ECO:0000313|Proteomes:UP000030708};
RN [1] {ECO:0000313|EMBL:ETW37691.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW37691.1, ECO:0000313|Proteomes:UP000030708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tanzania (2000708) {ECO:0000313|Proteomes:UP000030708};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Tanzania (2000708).";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI926346; ETW37691.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024WBS5; -.
DR EnsemblProtists; ETW37691; ETW37691; PFTANZ_01617.
DR eggNOG; KOG1175; Eukaryota.
DR Proteomes; UP000030708; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030708}.
FT DOMAIN 29..85
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 87..223
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 508..734
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 795..841
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT DOMAIN 882..918
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 315..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 110539 MW; 8C5832B7E6531A4C CRC64;
MNSYPTKEIY DDENNKNDGN HNIKNFQAYK AMYEESINNP EAFWGNLAKN NLIWYKLFTK
VFLGNFKKGN INWFVNGKIN ACENCVDRWV EKDPNKIALI WEQDCPDQYK KITYQKLLEK
TCKVANLLKL IGVKKQDTVT IYLPMIPELV YSMLACVRIG AIHNVVFAGY SAASLSDRII
DSRSTVLITS DFGLRGGKLT KLKQIADVAM DMCGMIQTCI VFKNKTKMKD KNIQIKTPME
NPIYNFTSFD SNSPQNFTIN NSNDFIQIKS THSHQSDHQN DFSLQQEDNN YTKNSNMSYT
TSMYYHDNNL NHINTNKNND HYNNNLNNKN YLNNNINDQS PMYVHTMNHN DNNDDNNNNN
NNNNVDDDNN SNIQNDEQSY FNQQNNTYNK NDHSDDNNKN KGKTTLHKKI TKNNPINHKI
SYSEKSYSKE LINTDMVNND NQFGDLKTNK KFININNIIT CNQNGYSPNK QYFPEPDKNS
TSNFDETLCV LKKGRDIDGT ALLKNMRSYC PIEYVDSEDF LFLLYTSGST GKPKGVAHTT
AGYLLYAYTT CKYIFDVKEN DIFGCVADIG WVTGHTYVLY GPLLNGITTV IFSSIPTYPD
CGRYWSLIQT HKVTQFYTAP TALRALMKYG DEWIQKYDLS SCRILGSVGE PINPETWRWY
YNVVGKKKCT IVDTYWQTET GGIVIAPIPH LFSMKPGCAS LPFLGVQLEI LDSKTLQPLS
GNNVCGLLCI KSPWPGMLRT VYGNHQRLIK TYFTMCPNYY FTGDGAFRDE DGYYWISGRI
DDTLNVAGHR LGAAEIEHAL VQHFYIAEAA VVSFHHNVKG EGILCFVVKK KGNIKNYSKG
ITDIVNSNNN NNRNELHNNS PFLICSNNIT DIEEFKKNFT DEKLIEQLKL YVRQVIGPIA
TPDLICVVPD LPKTRSGKIV RRILRCIANG ITDFGDISTV SNYEVIETIN NTLNECKKKL
KDIEIKK
//
