ID A0A024WI43_PLAFA Unreviewed; 1434 AA.
AC A0A024WI43;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMALIP_05118 {ECO:0000313|EMBL:ETW46837.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW46837.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW46837.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW46837.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW46837.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW46837.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; KI925619; ETW46837.1; -; Genomic_DNA.
DR EnsemblProtists; ETW46837; ETW46837; PFMALIP_05118.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699}.
FT DOMAIN 60..230
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 264..418
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 716..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1434 AA; 168952 MW; 92362E00E787988D CRC64;
MLKFLNVKSP VVSSDVDEIT DDSDKGDVSY TLEELRMKME ITQKKHFGYK NLKDFQVEAV
HATFHKKDSF IVMATGMGKS LCYQIPSLMD VCRKKFTIVI SPLISLMKDQ VDNLNRKRIS
SVFLGSGQKM NNNKILNEIK HGIYKIVYCS PEYALNNKDV FILLKNRILL IAIDEVHCMS
EWGHDFRPSY RKLNELRIIL KEIPIMCLTA TCTKNVQSDI LKNLNFDLQN CLIKRSSVNK
KNLFYSVREK TDIYHDLKDI LDIPLKESIE RTKKFIDNSK ICSYNSTLIY VNSKKECESV
YSFLKEKGLL VLMYHADLTN DQKKEAHEKF LKDEIQIIVA TVAFGMGIDK PDIRRIIHYG
FARSLEAYVQ QVGRAGRDNS DAEAILFFHI NDESKIKNII LRENTANNLI ETNFQRVEHI
VHIFTQASDY AYSTACRRKK IYEYFDEAPL TSYDIDIFND KRNEGICYYI KKYDIYLCGK
CDNCVYCLNL IKKKNGIKTN KINNNNNNIN IYSNSNNNNN INSNNNSREY YLDNDIKKET
SLKSLTCYYI SSSSNSSFSS YIFDNVVDLT NELKTLLNCI SSLKGKTGLS TVCKILVKSK
ESSIIKKNYH NIKEYGKGAH KSTNWWSSFM KVVRNDKFIK ETLNCGKEMC YISVGVTDKG
EEFIQSKEKY IIALPFFLNT SPKSSNTRNK KTKKDTYGKY SNNKETKYEN ITYEYKDKYN
DNDNDKDNDN DNDYSKDIYN VDDYKYDDHH ISSKIKQQQE QHNNNIRDIY YNDKDVEYDK
SIHNINKNTN KNLSYITIES GDEKGNTNCI INKENINRDN NFEKTHKNNI EKYEYIESYQ
KQKNNNKNNN IQINNKKYDD NKYEYFNINK NDFIMKENRY TKEEKILSDE QINDSIMKIL
LRTRMLEARK QNIPPFQLIS DQPLKDICHK RLTSVELIRK HVYNISPICP NTFLEKIVSG
IRGFCLLHDL KTDILNLNIY NPNHNNSPIP INAKTSTLKN FENLISSYNY YDRNKYAPRE
ESKSNETYSY EHYTGTERKC KHFVTQEDEY NHADISKMSR HTNIYEHKKN MNDHTYDLHN
YNNNITYDYG DIPKNTLIQY KNSLTDQNTI SMSDINSDNK NMVYNNHIFN KNHSIITNYN
SSAENNSSLQ NEFYRKKTNI IDDNNIGHHT YNINDNYHTN DVLLTNAIIK DRPKKKHDDI
FSNFCYKRDE SETRVQGNVT HVKKDINKGY QENKNDITFL QNNISQHTNN MIHNNGKDVK
NNLSALDDDD DDDDDFKFIN QIQTLGLHEQ NCKEENNYQN SLTNEHVHIP NYNLYQEENT
RNENEKRKIN INLKQEDQNI YTKRHQYLTN PNEHSVNNMH NIHLKENNIP KYDYTNQNVH
ESNQKKNDFY EEKKKKFNFI ESFSYNNNQE DKKRVNNLDI LDQFVYRDVK KRKT
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