ID A0A024WP48_PLAFA Unreviewed; 2022 AA.
AC A0A024WP48;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0000259|Pfam:PF00675};
GN ORFNames=PFMALIP_03296 {ECO:0000313|EMBL:ETW48758.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW48758.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW48758.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW48758.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW48758.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW48758.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; KI925567; ETW48758.1; -; Genomic_DNA.
DR EnsemblProtists; ETW48758; ETW48758; PFMALIP_03296.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 1.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2022
FT /note="Peptidase M16 N-terminal domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001537134"
FT DOMAIN 697..803
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT REGION 222..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1579..1606
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 222..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2022 AA; 238694 MW; C27E8D47ADA48934 CRC64;
MKHTKITKYL TINFFILLTL VFQKYSSCQN SLNYSKNNYG LNDQELRAML FGLNYDPSKR
NKNNKVNRDV IKNESSLLLR NLINEETLSE KNDKVVNDIK NMNNSTEKKI NSISKGNNNI
HNINENQNAN VELKTDNILD NTSEQDDINE KNNDNGDMVH KNIYNNILSD PYDINSTNAY
INKSDITNLN YSSNDVINND KVNKSYEEKN IVNNTELNKL IESDDHSNKN DINKKTEKNE
TFNSSSTSDE KKQTDIKGQN KNDLNNEHIF NNNDINNNVQ YKNKVNIISV DKNNTDRDNN
NLYETNNGDL KYNNDLIKEG ENKRNNKLNN YKFNMNKVND NKNFNKYTEI YNKESEPEKQ
NNSNNNLGIP TLIKKEVHIK NHNTFSSNGK ILENKDIDKM SDTSKKNDRN FRSNDIKNFK
NNDTKNNATL SEDNKNRYNI TTNKNNEKKE YNMKKSNENE YAFNTEKTNV NNDALKEERN
NYKYLNNQTD VNINNLQERD INLYNKNESD KKLEQSFREE DIKNAYLPEN KNFQKTLTNN
EKNEDNKIPH IDPSNNELDK KGNYNKYEIG KIKKNNEENK QNVTVEENIN PEKIRKDHEQ
NIQYSKNDPI TDIQNSTNAV LKKIKPTEFE NYTKEELQNV SSSEVRDDNL NEINRKGETN
MFSEKSTLKK GENDWNEYEY FKLKSNELKV LGIINKYSPK GGFSISVNCG GYDDFREIPG
ISNLLRHAIF YKSEKRITTL LSELGKYSSE NNSRIGESFT TYYAIGKSEN IYNILTLFSQ
NLFYPLFDED FIENEVREIN NKYISMENNS LNCLKIISQF ITDLKYSKFF FHGNYITLCN
NVLKNGLNIK KLLYNFHKKC YQPKNMALTI LLGKKGNSHD HYNMNDIENF VIDIFEKIKN
YDYVNESNNK RQKEKHIVNF KDDTFNIEKK SNYKDSRLVH NVTQNNSKDK EEKIKFIEHI
NEFNNYVLDL NQKGRYIEVL KKEGWRDQIY LYWSSKISID LYKKIEEYGS ITFIHDILLD
LRKNGLYDKI CVENQYAYDL KIISSCNKYY VNYGILMNLT KKGKKDLRHL MHIINVFIKE
ISKLFDHDSL NKGINKYILD YYREKALITD VNYNNDNKYI ELNDLINYSN ILLDHSDDSS
LILSINNLIE DKNKNDFRNH IKITSLLGSL MKNENTNIIN VVDTFSIRNQ SKIPYSNVTY
VIGENPYMVN EGNIVNDINL ILPEIKICPF NSLVNNKILF NEKSFFCVPY NSSENFEYSE
SEEKFISEEN KHIFKSNILY NIPCLIKSSY GYNIYFKRGL THISKVKTDF IFYFPSEKFT
FYESVFTRIH IIILQKKIER FLSDYTTCSV NANIMHDAIS YTLSIESNGY FFEEFFNKIQ
ELLSLKEIPS RDEYNEAYDE LNIIIQTDTT SGVDKSLKIM YSLFNKYTPT NKEMYDILNA
YFFYPSYNAY RTYVNEYFLR NYVVIFIYGN IIISDLKGEE NITKNNNNIF DNKKSMNYNE
GDATDKNNNS NNNNVESAND STNYYIYNEN NSSNRDTNKY TDNDYNNNNN NNNKDGDKYL
INEKIYEGEE NKKNPTTYLK KQEQFLEKQE NNNKEEENKS KSLQISYNGS GIEYLVKLCE
SFISKVTNKV IKKSESTYYT KKLINDEDIE IDMHDPGQDL SNSITVSYII DSETLLNNVL
INIIVDLISS DFIKFVKIKY NDGYVVEVRT FFTYNGLGGL LFIIQSFDKD VEQLESDICT
FVKYITFQLL NIDISDLKKQ LQNMKEHYIM NNTIFTFNQE YSSILDELIT GHECFDKKYK
IVQIFDELIN CPNIILNKIN YILRKSKKNI FKEYKKTNIV NIQSSNKDGT KGHDYLHLNE
KCNYSYRKNM KMSNIQFSDN SELFIKKQRK KKYKYIPSNG TTQSNNIYKK EHLFNFSNFV
EIKEKGFFKY IISYFRKNNR KYLNDDNYLD FESCDEEMSK DNFQIFYNFT NDINKIREYF
RGKFTNDKEV KENCSINYEE IRKYCYDHNI NKDNMIRTKI EI
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