ID A0A024WUA2_PLAFA Unreviewed; 910 AA.
AC A0A024WUA2;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Iron hydrogenase large subunit C-terminal domain-containing protein {ECO:0000259|Pfam:PF02906};
GN ORFNames=PFMALIP_01418 {ECO:0000313|EMBL:ETW50538.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW50538.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW50538.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW50538.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW50538.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW50538.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NARF family.
CC {ECO:0000256|ARBA:ARBA00006596}.
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DR EMBL; KI925518; ETW50538.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024WUA2; -.
DR EnsemblProtists; ETW50538; ETW50538; PFMALIP_01418.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1780; -; 1.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR PANTHER; PTHR11615:SF258; CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 2.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699}.
FT DOMAIN 438..759
FT /note="Iron hydrogenase large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02906"
FT REGION 206..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 107964 MW; EC57A868AC853C98 CRC64;
MFSNLIKLEN LNDYNNEAEK CIKPFLYKNS SIDDEENENF IQVERPNLIN IKKIKKKNYN
RKERGEISLT DCLACSGCVT NEETTFLKSQ NCIEIINTVK KKKINIISLS LQSVTALSVY
YKLPISTIQK KLCFFFKSLN FHYVYDSSLG ELITLNEAKK EFLEYFFKNN ETYENNNIYP
GDDHVGNVNR QKKKNILIRK IFNDKNKKKK NPSYNDNNND NNKNNDYDKN NDYDNYNDYD
NYKNISSYSN NSSNKFSLQY KDKKIGPKTF PLICSHCSGA VIYGEKNFDD DLLNSFSKIK
SSQDIQGIIL KILHLHNSVL YTYPSLNKYI YNNFFRLYNY KFNWLNICRK HFLKNYRFND
NASKKKNNNF DNNNDNDMGV FKEMETLNIY DINHVYLLYC FDKKLEACRI HEEQQISIEN
NMKNYLSRQN VDYNIFIKKE QDQNKFYCVD AVMTTVELIE LINNMNIDFY TLPELYVDNI
YNLIKRICQD DIRGVQNIVG ASSDVLNENV SSTTKMKHIK NNDDDDDNDD DNNDDDKNDD
DNNDDDNNDD DNNDDDNNDD DNNDNNNYDD DNNDDNNNNN NNNIHTAEEY KDKSVATGNM
NEENKKNNIM LNHTEVNYMK YIYDDLFLHY LIRCSHKNNI SMGYGEEIFK YVCKEIFNFQ
VDENRFNLKY EDIIVLSLFN NNNCVFRVIL SYGFKSMHNV LRKIKELKNE HTKNYKNVDE
QVLHHDQNKY HINITYNLLF NDRIDYVELM ACEKGCLFGC AQNIFSEPVE KFSYCSCNNF
DIFKKLDKQE IISNFDFLQE SNDKKKKETN KFCCNENHKN YVMNSLCNNN NNNNNIHTAE
EYKDKEKLFK KLFNTMHDDQ YILYVNSKNC IYDHTINSFL KNIFHVFNNA NFHLFKATFS
SKKKLDIINW
//
