ID A0A024WV67_PLAFA Unreviewed; 1290 AA.
AC A0A024WV67;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMALIP_00800 {ECO:0000313|EMBL:ETW51149.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW51149.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW51149.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51149.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW51149.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51149.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; KI925499; ETW51149.1; -; Genomic_DNA.
DR EnsemblProtists; ETW51149; ETW51149; PFMALIP_00800.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699}.
FT DOMAIN 837..1016
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 415..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 137..165
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 415..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1290 AA; 151779 MW; 45C0F50EEB6E9AEE CRC64;
MTLSSSESSI FSETDDDSYK EEDYTYNRDE NIKNIKIYNK IIIKLFLKNR KYYEQIKRIA
LGYISKIEDI EFCNVQNNEQ DRNEHIYNFY FDAHDAIEYG ENKLIYYLQN SYHKFMDVIN
NYSIPLFFRI IFLSCYFEFL NNEENEKKKK KKKKKKKKKK KKKKEDFELF RTNENDMYEK
ENEHLWQDKN EEYNNIHNEK YINDKNSINN DDTKKKKKKT LDQVGKGRVK ENDMDYFFNN
FIEYDFCKDN DVMEQIDLYS SCLIKGILFS YMKYTFLKKE EIKLKINNCL KMIFVRHNIK
IKCRLINIPY LHDIHINNIQ EIENKHIGKF ISTEGIITRV GEKKILEESK KYRCMRCDYV
IKKNAAPELY YNTETFFRCP NIIVNTKKMS SDILYDINDK ITKEFITKKM DKNKKKDDSV
DHNFEDDNDN NHYNNPLYSN RTNQNEKGIY VKKRCNSTNF EFIENEIKRV DYQEIKIKET
SKSNIPYSIT VVLLENLAGK YHPGKNVIIN GIVLRRWKRL YKDIRCDSEL FIEANYIEIK
ELEQIKIKEI SLDDDFSKYI NSIVSKACLR DQQSVFCGEE EFMENASCGG NDNLCEQMEY
DICSNKRGNI NVDDINVDNI NVPQDNQCYP INTRLIPQNK RRKDEHINRQ VNHISFTHLN
SVDKRENVFE KYWFFFENNK IEGKKYICES ICPNLYNCKL SKLSILLVLI GGNKINNEYE
SFYHENNKWI KYFSKNYKKS KKKSSIGNVV RDNLNVNEEN EMVEDSYEED SLEEMGERIR
KKTRKGNKNE VKKNDIYQKE NNIYNLYKTN NISNIQYDEM ENTKEKRKRK QRQKQKQKQT
KFESDNCDKR TLCHLLLVGD PGTGKSQLLK EVQKLSNICV NVSGMFCTTA GLTCAAIKEG
NSFMLESGAL VLADNGVCCI DEFCLMKNEN KNAIHEAMEQ LSISVAKGGI VDKLNCRCTI
IGASNFEINK EVKGNLSNYD SKVIIINLSY ALLSRFDLVV IAEDNSQIDY KIADYILSQD
VEVKKGLDNE YVNNNDNIKN NVLDKNNMNS NMNNCKSTTC NNYTENNHLE NLPGSYINNG
HKKHNEPIGH DSIILSPFNS DNGNGGTFEK KQNKINKINK INKINKITWP SEKLKEYINY
VKNGFFPNFD KSSKLILITY YSTLRKYNDG DNGTTVRTLE SLIRLSEAHS KLILNKKVTS
DDVINIILLV ELSLRGYQIA IRTNANNILI ARTGILENSA YLLQTYNSNY NTFYCLDDVL
FDDSLYIYFK NIILEKLQLQ EINGKIHKML
//
