ID A0A024WYD8_PLAFA Unreviewed; 1515 AA.
AC A0A024WYD8;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN ORFNames=PFMALIP_00092 {ECO:0000313|EMBL:ETW51851.1};
OS Plasmodium falciparum MaliPS096_E11.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036727 {ECO:0000313|EMBL:ETW51851.1, ECO:0000313|Proteomes:UP000030699};
RN [1] {ECO:0000313|EMBL:ETW51851.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51851.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW51851.1, ECO:0000313|Proteomes:UP000030699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MaliPS096_E11 {ECO:0000313|EMBL:ETW51851.1,
RC ECO:0000313|Proteomes:UP000030699};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum MaliPS096_E11.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KI925476; ETW51851.1; -; Genomic_DNA.
DR EnsemblProtists; ETW51851; ETW51851; PFMALIP_00092.
DR Proteomes; UP000030699; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01370; KISc_KIP3_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF13; KINESIN-LIKE PROTEIN; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000030699}.
FT DOMAIN 918..1257
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 51..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1272..1299
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1378..1498
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 51..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1011..1018
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1515 AA; 174350 MW; 10372A341BB8A39F CRC64;
MESGNKKRID TYEENEWIEK EEGNNLGDNK NADYFVSSNI EDVFISNRTT ENENEEMTGE
FMSSSDISNK GDEKNAYKRV RHKEINKEDM HIGNNHNYVM NDNNDDNNIQ NNVSNNVEEN
IQSISFIDHE MIPEKMNILI NNNNSNIIND NIYIDGNNHN NMYIDHTPSD NIYNNNEKHT
KELYDKKKPC GIYKNTNSNS NDHFKEAKDE GNNNPVDELM KDIKMFNNSM QSIYSTNNLS
FQKNLSKMYS ELASNKNLES LHNLFKDTSF GGNMEKAQFL KNILLASCLP QNGMGIKKNE
VAINKDIENN KEVEKINNKI LINDPRNVQV SQYIKKKKSS NYNLNEYTEE SNITNLSESQ
NLISNMEPTT VFSLSSHKNN LDVKEGDENV GKKETPKFLE DVEINTNDLN IRDDISPLNL
NQYKETSMIN IWNKSSSKKN ISSNEWDKMK KSFCNIENNL IDFNKLNKTS NENVIEGIQN
QIIDEEMKNI ETSPFINYLS NDNIMTVGNT NISNERFPVL DYVEQMGSNE TMFYDNFDKY
QVLKDHTSNS FHLYNSNDSS KVSCADQDIN KMDVDNINNK MDVDNINNKM DVDNINNKMD
VDNINNKMDV YNINNKMDVD NINNKMDVYN INNKMDVYNI NNKMDVDNIN NKIDVDNINN
NIYVDNINNN IYVDNINNNI YVDNINNEIY MDDNNNNDDD TDKHSNIYKH MPTKCHINNI
SPTNAGDRSK MSSPALQSMR TKIGNTNLLT KEEEGGSNLK ICKNELSKME HTKVNTIKMK
SPKNISKVCQ NKSTINVPKV VKVKSKTNEN VKTPKMTKRN SDNTTGRGDQ KMNVNQINNN
INVNNHVTVN NNNNNNNNNN NNNNGSVNNH IQVHEGSNNH GVSSLSPVHQ NGTLTNNICV
KSNKNEKNAS GEKDITYNMN VVIRCRPMSI SEKNDGAKNV IKILENKMVV LLDPSDNSDN
VLRQNRSREK KYVFDYVFDE NSSQEDVYNN SVKCLIDAVI KGYNSTVFAY GATGAGKTHT
IIGYKNEPGI MMMILKDLFE RIKMLQIMNE YKVKCSFIEI YNENICDLLN PSNEYLDVRE
DPIKGVTVSN IFEVCTTSVE EIMELIHTGN RNRTQEPTDA NKTSSRSHGV LQVIVEETEK
GQGVYQQTKR GKLCVIDLAG SERASQTNNK GMRMLEGANI NRSLLALGNV INALVLRSKG
NSKSNFIPFR DSKLTRLLKD SLGGNCKTVM IANISPSHLS YEDTHNTLKY ANRAKNIKNV
VTANSIVVKH HLTMYIDVIE KLKNEIEFLK EQLNEKEKIH GYMSTNSTNY DYYDQLKDYE
KNYSKEELIH IIALLKKENQ RLKMCDTHEG PMNNNESGAI INNNNDEQHN NVNDNFNHNE
YDNNNNNNNN NREKLNHDIL TNKHNEELAK YKEEVNNLKM MNEKLFMDNK NFQLKLQEYV
NISKNLKTLN EEYKKQIEAF KSMVHNHDMN HIQIKKKLDD LKKKYAQLKE STDDKDNDDV
LEKWKNELTK VIKHM
//
