ID A0A024X5G9_PLAFC Unreviewed; 4226 AA.
AC A0A024X5G9;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=PFMC_03449 {ECO:0000313|EMBL:ETW60749.1};
OS Plasmodium falciparum (isolate Camp / Malaysia).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5835 {ECO:0000313|EMBL:ETW60749.1, ECO:0000313|Proteomes:UP000030694};
RN [1] {ECO:0000313|EMBL:ETW60749.1, ECO:0000313|Proteomes:UP000030694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAMP/Malaysia {ECO:0000313|EMBL:ETW60749.1,
RC ECO:0000313|Proteomes:UP000030694};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum CAMP/Malaysia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW60749.1, ECO:0000313|Proteomes:UP000030694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAMP/Malaysia {ECO:0000313|EMBL:ETW60749.1,
RC ECO:0000313|Proteomes:UP000030694};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum CAMP/Malaysia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI927523; ETW60749.1; -; Genomic_DNA.
DR EnsemblProtists; ETW60749; ETW60749; PFMC_03449.
DR OMA; RINEEHI; -.
DR Proteomes; UP000030694; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR PANTHER; PTHR24092:SF219; GUANYLATE CYCLASE ALPHA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00211; Guanylate_cyc; 3.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030694};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2079..2106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2118..2138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2168..2190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2202..2225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2234..2258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2270..2294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2791..2808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2828..2849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2861..2879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2891..2919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2931..2951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3737..3760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3775..3796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3808..3831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3013..3270
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 3970..4104
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 552..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2475..2505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3077..3150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1749..1763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2475..2500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3109..3141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3215..3230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4226 AA; 496130 MW; 0C4E4CCBB3E23E24 CRC64;
MSDSKKHYNE SNVRYKVKYS GKIFGNNMKK LNENNNHDFT TAEAAWMEKK KKLYKDTNNQ
PLWDFRKIQI NPTETDELIS FPSNKICSKN YGKYSFIFKG LYEQFLRLPN IWFLLISLLE
FIPQYQNLSN YMYYSKHSSF FLLLFFICVS IIKNIYEDSR RSNIDYQINN RLCHMLDGPN
SQLKAVRWME LSVGSIIRLI ENEQVPADIL LLSCNNSEGV VYIETSLLNG ETNLNKKYCV
NETRNETSIY AISNIRGRIV CEKPNSNMES FNGSLKLDAH PRATSLSINN VIFKGSHIKN
TEYIFGVILY TGNDTKIMKN ISNNKHKLGY VNKELNSYTI IGLIFTFICV FISVLFKWTE
DDKFRNGSHF FLITVKDNIC ESIVKYTLLY SNIIPISILI SVDLISILQS ILIENDNHIS
TFENYETSEP STIDDMDNEL GDFKMDKSHT FFKKYTYFLN NRSKNFTNNR YSSTNTERAS
DFRKSFFGTF DKLKTIKRYF YSIKSKIKSI SQSNTLYNKS SAGGSIIRSD KNKQTTFSKS
FIDIFQRTNN NEHSQTLDNN NNNDNNNNNN ICKEKYQNVN NSKNVYVSED SSNNKYKQND
YLQKSQEQNE IHSINNNNYN NKNDNNLQTE FSNHNFRINA YKTNRTTKDD TYNNKHISLN
SRSKSNQKGI LINSNEINRK KKKNLLQKIF PFFKKKRTNI SEDLSKYVFR RSKQLNINHN
NSEKYNLNDY DEYGWGLCLN SNMHGDLGNV DFIFTDKTGT LTNNNMTFNM CSIAGKTYGS
KCKNKKKIYN NPKSNNDNKL NSYDKNIFKN KFSSEASIKK ISFVRDFSNN VSSKNDLTLD
DPTELISDEG NNYLRDKYEH TSDKKNDTNK NRDGANNSNN NNNKDVSNNK NKNNNNYNYN
SNNDYIKQNG ECNIYNNQNN TNNTHNNNIY YDEYNNTNEG NMKNTNVNKD TNSKCNKKDF
IINTSDIINN NNNNNNDQKT NNLKYKSSSS WNSKAKKSSY INLNSYNKYQ SFQNSSMLSS
SLSSTCSSET EDENGSQLMY YSSSNYDNLD INNDMDSTKT YSHYTEQNYY NSVKDDKDQN
SEHQRYQQKK TNKQTKNIQQ NQCDQWEDNR YTQESIKNQY FFDRNYQTFL MKQNFRRPKS
FRLNMNSSSV KGRCDFNDTK IYNDLNSQSW RGYYIDEFFK CMTLCHAVTP FIQFDYIRNK
HLTYTNSRSS KGISNNMDRY NINPTTTTTN NNNNNNNINN INNINNNNNN NNKQFSCDYM
KNRNDIIFET STDYYANQDN AKRKREKTLF DNVSHCGEIQ EYRDNKKYRM KRSQTCSNNR
KIFSNQRTLY DYRNMNNNLK NKNSYLRNKL KSKIFLDKSY RKRKKSSGTY KGSDICKGIE
KKETRRWKRF LHMKGSNNRN IFSRIKDFKS NSIIYNNQDK TNDYKNGYSN NINNNNSNNY
TNEKINRSFN KRHSAVSFKQ MSKEKLIPIN NVLSNRCDVE SYPNEELSFS KKKKKNSEIV
SFASGKSDIG FEERTDAGIA GKNMELSYNE LEKYKYVKHI DSNNKYINNN NNSIHMSHMS
SNNNTFESHI YFDAIKYQSS SLDEECLIYS SSFLGYRLVL RNKNTMCIEI DGSFNKWTII
GVNEFTNRRG KMSIVVKPDS MESGSILYVK GSDSSILSLL NLKYSKFLDK KYSRKRRNKN
IQKYKQKREE YNELKSKDIN IEEFQKSKSL SLKNFKNNTP KVLFGECTLD YNNNNINKNY
KYDKNDKHNN NNNNNNNNNN NSNYSYNYLH DSNNLDAMQN QKYSYAYEDK EDYYYTNNGE
CNKYKERYRR LEKQLRKFSV KGLRSMIFAF RYLSEEETIK YKRMYDDACS SIYNKEQRLE
KVAEEFERDL IYLGITGVKN GLQEKVPKTI DILNQSGIRI WMLTGDNVEY SLHVSFLCKF
LNKHTKIFHA ALENSNAKKL KREGMALYEL FQLEKEEKKP YENLCLLVNG RNLQTFLNYT
DLQTHFLNMA CTCDVVIACR ITAKQKAFLV QLIKNRLYPT PNTLAIGDGA NDIAMIQEAN
IGVSIMTSDC IISAGYSDYC IKKFCYLRKL LFIYGSKHLY TISIILYWNF FKNILLILPI
FFYQAYASWS CVKIYPELLY TFFSIFWVFI PIIYYMFLQH NLNYDILYNI PLFYALSRRR
YNMNCFKFLP WIFEAIFYSM IIYFFAYAAL KENSHLNNGE VITINTFGNI CFIGCLLISI
LRLFLEGSLW SPSILITCFG CFLFVFFPSL LFICFAYLSN EYIREVFRQT FLWAPLYVLL
ILWFSTCIIS YIFINFTKSI LFPNIYNVVN HWLFEQYQEK HNKNKYIFSL SGKNKFLKLR
KLGKKIKFKF KRNYSKKYDT NVIREHPLLH HTFKSEQDQN KCNEQFSKDP FISNSLLKSK
NCKFKKDSSY SKSNIHVDEE QTYKGLKVVL SEQVVHAKEN LVSFKNEKKN KNNKNTSMNV
NDNIIIKNNN INIKNNDNNN DDNDNDNNNN NNNNNNDNYN NNDHNKKEFK QKHIQNNYEN
LFNHTQVENN LIKENLSIRN DNNRRDNKNE TDYIKQSDED YEMNPSITSL RKRECINDSK
YIDNKSYDNK ISNNHEEKDG FKSDDRSLIN SNMMDYKNEF TENDTTYSFN DSHMFYDFPS
NSKTTKDYKV INSRIDDSIM ADMKNCLNPL KNTFLVDLLP PGKRFRINED HIYFKNNERM
ENIPEALDVN KKYYHIIQNK AEYYDNDSLS EFSYTSSNSS INNKKKNENT QKEIVKVSHL
INRFTLAFKD MQLESGFQIH KKNKFYKTFT PWYRFIFLLL GVFFLYVWKL ESSLSQLWNM
PSDASTDVFI LFLSLLLELV LLAATVTTFF SNIFIENFNK IISAVVILII TYHVVSYSVT
HIDGVFQAVL FPLYTFVILR LPFVNAVLCN IIFLGLFIIR FNGDHFLDKK GLAHYIPLFI
GVDVFVGFVG YRLEYNQRKN FLLEYSVESS RRKQREILNT MLPPFVVDEM IYSELNEEGI
PISLKAEDIS TVTIIFCDIY DFQNIVASIE PTRLVEVLDR LFLCFDKCTE QFNCTKIETV
FETYLAACGL VKREKDEDEL ENNKYSNNNK NNNNNYYYNR KKKKKKNNNN NNNNNNNNNN
NNNNNNNLNN NNNNNNVNTS DDDGDFFEED DANNHQIYNQ MKGQEDAHDS IDFALSILHV
SSHIKYENSK MMLKKNDSFE DANDDTHNVN DSFNNDKAEN DNTNTDNNKP TRIRVKVGIH
SGRIIAGVVG SKKPQYALFG DTVNTASRMK TTGKPDYIHI SEATYNLVKD DKTLIYEKKE
TEIKGKGIMT TYLLTSVIGL NYPFLGEHVE KKGHFISELY EDDLSNNLNY DKTQNILGYY
SNKINQNNDS NINEGIINNN MNTFNTIDGD TSNYYVNLKD LSLNDLPNEY IKDVNTHYCE
IIKLRNLKIG TAVGYQLKQK DFYNMTFLNN GLNNDTATNF NQYIESHKDF DDIKDLRIGM
NKLSISDSLY YLNENVIRNE PINEYKNKIK INSVNTNKKS YEDAHLNAGN IIYTNNEYPN
GQNIEEDDDL LLTNHYNKTN VNNNNNNNIY DVSKELIEHN EEDYKNILMC SKRCKNCNET
YCTPNDCNNN DHVYHVMYHR KLSNIKKNYL KNIRKDANIK KDIEKEELNK IHSNKKSFNF
FYLFSYIFKI FPFIGKINKE EKKNKSYKKG EQDKSSKRII ALNSEWIFLK FSDKNLEAKY
RAHFYSNKSN INSIEQALII FLVTFVMQTL ISSTVSIVFI DHKRATQTLH INYFAYWSVR
SVYTFFGFVL WLLFHYRTRP EVSSLLNIKW MIFFLNLLFI SAACVFSIAY LWAISETDQT
TSYTIWMTND TIEFFFYLVI LHHNTGMLFQ TCILVDLLFI TMSLTFIATS VVKTITTDST
VLLIPWYVAF NLISTYCKES IDRRTFYANE SAKKTENRAT ELLNDMLPKH VLEEFQQDKL
KLAYTHDRLT FLFADICGFT SWANGVDASE VLTLLQKLFA KFDNDSTKYG LYKLCTIGDA
YVAISEPVTE DNKDYDPVDG TERVLEMAYS MIRIIKEIRE KLYIPNLNMR IGLHYGSCVG
GVIGSGRLRY DLWGIDVLTG NLMESNGIPG KINVSETLKN FLLQQFKNRF IFKPHTTIRV
IYKDVKCFII TDKKEVESSN HSKLLQNKNY LLNKKFSTQN YLVKNIFAKK KHSSISSSKN
IHSYDEKKKK KNDLFYINVN DRQSNL
//
