ID A0A024XFQ7_PLAFC Unreviewed; 904 AA.
AC A0A024XFQ7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=PFMC_00345 {ECO:0000313|EMBL:ETW63786.1};
OS Plasmodium falciparum (isolate Camp / Malaysia).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5835 {ECO:0000313|EMBL:ETW63786.1, ECO:0000313|Proteomes:UP000030694};
RN [1] {ECO:0000313|EMBL:ETW63786.1, ECO:0000313|Proteomes:UP000030694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAMP/Malaysia {ECO:0000313|EMBL:ETW63786.1,
RC ECO:0000313|Proteomes:UP000030694};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum CAMP/Malaysia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW63786.1, ECO:0000313|Proteomes:UP000030694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAMP/Malaysia {ECO:0000313|EMBL:ETW63786.1,
RC ECO:0000313|Proteomes:UP000030694};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum CAMP/Malaysia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; KI927462; ETW63786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024XFQ7; -.
DR SMR; A0A024XFQ7; -.
DR EnsemblProtists; ETW63786; ETW63786; PFMC_00345.
DR OMA; LICNERN; -.
DR Proteomes; UP000030694; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17748; BRCT_DNA_ligase_like; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000030694}.
FT DOMAIN 213..311
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 104185 MW; 5B2982CCAAB13F0B CRC64;
MSSKDKNLFS DDESDDGRKK KRLKKVSSSL FHDDDDDNFI SNKKVEKSKS KKKSDAIYID
DNESNNNNNY NNTNKSSNRK SLENKSSKTS PKFYDITSFF KPSSKKLEDN NTMKKSNSKE
DEKLVVNNLN DYFNILQNDN KVTKEDTKSN NVSPKNEINK SNVKRERESE QYEISSENDT
VSSKKNVLIS PAKKQKTQNN NNEDLQKFDY LPFHNQKFVI TGVFKNFTRD ELQSKIKEHG
GSVMTAVSTK TNYLVHGEYL EDGRLFNEGR KYTKAFELQQ QNKSNIKILN EEELLKLLPQ
TDQTQENDKT YASDTIKTEN KDKNYNYEKK DKNYNYEKKD THNTQNEILN QLWVEKYRPK
NLNELVGNNQ NVIKLQNWLA SWEDVCIKGI KKPAQKTFRG IFENVNARCA LLSGPAGIGK
TTTAKIVSEA SGYNVIEFNA SDERNKAAVE KISEMATGGY SIMSLNNRKL TKTCIIMDEV
DGMSSGDKGG STAILKLIEK TKCPIICICN DRQNNKMRTL ANKCYDLKFS MPQKNSVVKR
LLEICKKEGI MMEPNALELL WESTCGDIRQ MLNTLQLLSK TYTRIQFLDL KKELNNSNKN
IQSLANPFEI TLKLLNFNES SKLNIREIMD LFFVDYELIP YFISENYTNV FNETDKSSAS
LNKWNVFSQI AHDLSLADKI KYNMKSNMDF ALLPHFAILS CVCPVMRIKI LKSFMSGRVN
FPTAFGKIST FNKNKRLLNE LCFNLSYKLN VCPKYMVTSG FLNYIYFKIM TPLHKADVNQ
AIQIMEEYSI TREMVTENLP CLRLPNQENL YDKLDTKLKS SFTRLYNSSH VIKIDPNSMK
KGLKSSEKKT TFKLNEFESD EDIDELSESK EDKDDDVLIK TKIDRKGTLK TKPSTKVKSM
KKAK
//
