ID A0A026VX76_OOCBI Unreviewed; 972 AA.
AC A0A026VX76;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=X777_15586 {ECO:0000313|EMBL:EZA47459.1};
OS Ooceraea biroi (Clonal raider ant) (Cerapachys biroi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Dorylinae; Ooceraea.
OX NCBI_TaxID=2015173 {ECO:0000313|EMBL:EZA47459.1, ECO:0000313|Proteomes:UP000053097};
RN [1] {ECO:0000313|EMBL:EZA47459.1, ECO:0000313|Proteomes:UP000053097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24508170; DOI=10.1016/j.cub.2014.01.018;
RA Oxley P.R., Ji L., Fetter-Pruneda I., McKenzie S.K., Li C., Hu H.,
RA Zhang G., Kronauer D.J.;
RT "The genome of the clonal raider ant Cerapachys biroi.";
RL Curr. Biol. 24:451-458(2014).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; KK107847; EZA47459.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A026VX76; -.
DR STRING; 2015173.A0A026VX76; -.
DR OMA; CECQAWS; -.
DR Proteomes; UP000053097; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000053097};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 23..972
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025075853"
FT TRANSMEM 391..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 159..257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 544..694
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 899..968
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 482..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 107079 MW; B77E4ED0B5EA7D1A CRC64;
MRPKSCSLFL LFCVLLPGVV RPFTSGEEGE DAAEDEDSYL LEEDDVPSAT IASDTELISE
GGVHLPVFLT EPVNSFVVKN KPATLHCKAA HALEIYFRCN NERVKDSQQQ DFVDPHTGTR
IVDCELNVTR DHIEEYFGKD KFKCDCIAWS GSGQIKSQPA IIDVAYLKKQ FESPPYSVSV
EAGQSTELRC LPPVGVPPPR VYWLRNNIPV DTESDTLLVS SEGHLLIGQA KLSHQANYTC
VAENIAAKRL SEPVSLTVYV NGGWSSWSSW SECHSRCAKG GQKRTRTCTN PAPMNGGQPC
LGPSQQKMDC NTACPVVDGG WSRWSAWSVC GSDCTHTRRR TCDEPPPSHG GRPCQGRDIS
VANCTGGMCN VGNAKVGGAH LTEEANRQMD VALYVGLTVA CVVIGGLAIF LARLLRRKGR
DHSLYSMARN EFQPEFFPDQ DKKLSLQPDV TATSVPACYE YPFDPKLSMS RSLSEHHYDV
PHLSIAPQPS PMSPTPSTST QESCSDKQIH SDSENSVTSS YPSSDSTYNV ASESVRLPKL
EAGNVARAAV NTRGALLVLP DSGISMSVPE GAVPKPLREE LYLAVLNEDC YRPRLPDGIT
QLSAVVTCGP SSATFNKPVI LQFEHCAMLH PATWELSVWA CDGVNVDDGS SSMTSKDHQS
ITWTRVLTLG NETINTPLFT QLDHAEAFIV TEQLRGYVLA GQSCENSIAT KRLRLALFAS
QAGQCCVRVY AVEDTKAAMK AIIDRESQIR GYLLDKPRTL LFQDNGESLC VSLEEVGNEW
QSKSPTERQE VPFRDIWNCQ ENAKHVTFGL DTAFGPTTTR SYKLQVSQGN SDTRQVFRIV
YDGAKQLISS GSVTRPLREV TVVSSGHANN ATTDSTTLRP FRFTRSLRKQ LCQCLDPPNA
LGNDWRMLAQ RLQVDRYINY FATKASPTEH ILDLWEARHR EPTAVTDLLN HLRVMGRTDA
ATILEAQLGP WL
//
