ID A0A026WF98_OOCBI Unreviewed; 565 AA.
AC A0A026WF98;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
GN ORFNames=X777_05012 {ECO:0000313|EMBL:EZA54727.1};
OS Ooceraea biroi (Clonal raider ant) (Cerapachys biroi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Dorylinae; Ooceraea.
OX NCBI_TaxID=2015173 {ECO:0000313|EMBL:EZA54727.1, ECO:0000313|Proteomes:UP000053097};
RN [1] {ECO:0000313|EMBL:EZA54727.1, ECO:0000313|Proteomes:UP000053097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24508170; DOI=10.1016/j.cub.2014.01.018;
RA Oxley P.R., Ji L., Fetter-Pruneda I., McKenzie S.K., Li C., Hu H.,
RA Zhang G., Kronauer D.J.;
RT "The genome of the clonal raider ant Cerapachys biroi.";
RL Curr. Biol. 24:451-458(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; KK107238; EZA54727.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A026WF98; -.
DR STRING; 2015173.A0A026WF98; -.
DR EnsemblMetazoa; XM_011339828.3; XP_011338130.1; LOC105279798.
DR OMA; LVYAQIH; -.
DR Proteomes; UP000053097; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053097};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 436..475
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 145..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 93..129
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 153..195
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 64205 MW; FCC117E55C4320A3 CRC64;
MMSVIPMEDG NMTRIKQKLM SNDPRKEETR SFLNFSRENL NISQADVEQG YHRSQLRPTR
NTILSLIALV IAVLCLSLEG WRFQRALVNT HEIEQLKRDV ETMKHQLLQQ KLVNELKAFE
QQNQTKLKQM LNSHLQLLEE LYGGGSIGDN DSSETDFDYE SNYDEDDDDD HNDDVDGDDN
DNNDDDDEDD DDDTTSQEHP SNYHIPSTNA SKSSDLSKNT STSISTSEFK TFDEMIAIIS
KTHPSEGEIE KNADHISEDQ EKIDNSNSTK HKRDTLAKDI ANMKHVKKNS KTKRFVSNHN
AVINDSSADT IKLDNNRTTT PYGMDPNASD EMIYDADDFD SISDTFKGWG QGTTDNNGTT
DGQTTYLDNT SDKIKHSQDS KKDSKKSSRK LTRRNLRTPR QVRAIHYGAD STLFSSNDEH
TGNGRVRHSS GVFKAWRPSD WVADLGMERF FSLAADGKLT VHESGLYLVY AQIHYLDEHD
ENGFHLLVND RPVLQCMVYS PGVGHKSRSC FSAQVIVVQP GDRLLLKEVG SERYTLFQHD
KSFFGMVKLG EVRHIKRQEN TSKTP
//
