ID A0A026WVX8_OOCBI Unreviewed; 2029 AA.
AC A0A026WVX8;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 03-MAY-2023, entry version 38.
DE SubName: Full=Otoferlin {ECO:0000313|EMBL:EZA59254.1};
DE Flags: Fragment;
GN ORFNames=X777_15897 {ECO:0000313|EMBL:EZA59254.1};
OS Ooceraea biroi (Clonal raider ant) (Cerapachys biroi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Dorylinae; Ooceraea.
OX NCBI_TaxID=2015173 {ECO:0000313|EMBL:EZA59254.1, ECO:0000313|Proteomes:UP000053097};
RN [1] {ECO:0000313|EMBL:EZA59254.1, ECO:0000313|Proteomes:UP000053097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24508170; DOI=10.1016/j.cub.2014.01.018;
RA Oxley P.R., Ji L., Fetter-Pruneda I., McKenzie S.K., Li C., Hu H.,
RA Zhang G., Kronauer D.J.;
RT "The genome of the clonal raider ant Cerapachys biroi.";
RL Curr. Biol. 24:451-458(2014).
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DR EMBL; KK107109; EZA59254.1; -; Genomic_DNA.
DR STRING; 2015173.A0A026WVX8; -.
DR OMA; WANIYGA; -.
DR Proteomes; UP000053097; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053097};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1996..2018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..357
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 395..530
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 934..1063
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1129..1257
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1510..1627
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1747..1897
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 110..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EZA59254.1"
SQ SEQUENCE 2029 AA; 229565 MW; 4F57C66BC5D050A8 CRC64;
SFTWNLGRPV DEAEVLQLAV VSRGVLRNEK IAARYGLVLQ TVVREGRILI SDSLVDLNNK
PLPAVVCFEI RYNPPDGSCS SYAASELTED EHKMLIDIEQ NIANLERSLE QANSSNGKRR
GSWHTPEKTS KRGFLPRGTS LSTSDKSPET RKRSTTLKSM RSLLKLGKQR PPRARSCDSN
SETRELLDRR DSSCPTSNEP SRTNSMTSLE TNASDNDSQP SANTERVETV LKPAKRAKSK
TSDTGQSALK AQDYQVCVTI IEARQLAGLN MDPVVCVQVG DQRKYTSVKE STNCPYYNEY
FVFDFHMPPV MLFDKIITLS VQQSRNLLRA NLTLGIFKLD IATVWAQPDH QFYHKWALLT
DPDDIVGGPK GYLKCDISVI GKGDTVKIPP KSEKDEDDIE GNLLLPDGVP IERQRARFVV
KVYRADGLPK MNSSIMANVK KAFTGEVKDL VDPYVQVSFA GLSGKTSVKR HSYAPVWNEQ
IVFTEMFPPL CQRIKIQLCD NDPVHATVIG THFVDLKQIS NDGEKGFLPT FGPAFIHLYG
SIRDYSLIDE HSTLNTGLGE GISYRARLLI AIRTEITDNV EMAPSEVEVE PTVPVNETAY
ARNEEFFLFS TIMDATMIDK KLGDKPMYFE ISIGNAGNAL DGHNESFKMY DTGSKSGTSG
EEDDLLEVIA GSWQSTTPSN KPMTHDKIYY FLPYWDDKPC LHVRSIWPDY RRRMYNSNII
GKIVDKLEEG LSEVQAHLED STCEKLLKTS LEELSANCNR YVSISKSSVT GPGVGKTKLD
KERTKLCQRE LENIGIMSRN LKALVTKSSF KERLKTAQSY LQKLKFLVED PQDSLPDVFI
WVISSGRRVA YQRIPGRELI YSVVDEECGR HCGKVQTMFL KLPGKKKFGP SGWAIQTKLQ
IYMWLGILKH KKYFIQGLPK GYEISHELKN VDRPRALPPI VIHYVQKHKF QLRAHMYQAR
SLIGSDASGL SDPFARVICG EFCKCTQVID ETLSPTWDEL LLFDDILIYG TAEEIKKDPP
SIVIELFDQD KVSRIVAMDI TLHEGSALTG KSEYIGRAIA RPHVKLASES YTPPQYPPSL
EWYDVTRGAS RAGELLAVFE LLEYPSTKDY GFPTLPDPKD FSSGSQVPGS GQDQGPILPV
PVGIRPTLAK YRIEVLFWGL RDLKRIHLLT VDKPRVDVEC AGHILYSSVI ANAKKNPNFN
TPIKFLELEL PEQELYRPPL TIRTVDCRSF GRYTLVGTHT INSIHKYMYY PLTKRAKDAQ
ERKKSLYQLQ CMALDSSKSR YQTSLPDSLT DLESNNGDTI ITLGFELGCG PTKKDKTEQN
LRRKQSLSND NSVGDLGALE DGDGCQDWWT KYFASIEAMI EENRELRKEK SILQNQPNGT
LPMFLDETTQ GQLAVASEKS PGINPTKKLF GLKSPANAAK FVSRLSPKQT QGKSKKTALL
KIYAGELEAQ PEFEQFKEWL HTFELYRGKK TGDETEDESR IVGSFKGALK VYKWPLPKDL
VDYTVMGFDP QYGFFQGVPS NDPIHVLVRV YIVKANDLHP CDLNGKADPY VVLQLGGKRI
SDKENYVSKQ LNPVFGKCFE IEATFPQDSL LTVQVLDWDL VGADDMIGET KIDLENRFYS
RHRATCGLAR KYDESGYNKW RDAMKPTQIL SKLCKDGKMD GPVYSHGRVT IGRKTFSLSN
EEMEFYVHTK GMEEHLALAV LHQWNAFPRI GCALVPEHVE TRPLYNPEKP GIEQGKLEMW
VDMFPMDMPS PGPSIDISPR KPKSYELRII IWNTDDVVLE DDAFFTGEKM SDIYVKGWLK
GSEDCQSTDI HYRSLTGEGN FNWRFIFPFD YLVAEEKIVI NRKESLFSWD ETECKIPARL
ELQVWDADHF SADDFLGAIT LDLNRFPRGA KNSKLCSLSM LKTDGSVPMV NIFKQKRIKG
WWPFYVKKEN EDMELTGKVE AEIHLLTKEE AEKNPTGFGR SEPDPLDKPN RPDASFMWFL
NPLKSIKYIV WHNYKWAILK AIIAIGLIIL FLLFFYAIPG YSVKKILGA
//
