ID A0A026WWX7_OOCBI Unreviewed; 1221 AA.
AC A0A026WWX7;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN ORFNames=DMN91_010556 {ECO:0000313|EMBL:RLU16488.1}, X777_13432
GN {ECO:0000313|EMBL:EZA60343.1};
OS Ooceraea biroi (Clonal raider ant) (Cerapachys biroi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Dorylinae; Ooceraea.
OX NCBI_TaxID=2015173 {ECO:0000313|EMBL:EZA60343.1, ECO:0000313|Proteomes:UP000053097};
RN [1] {ECO:0000313|EMBL:EZA60343.1, ECO:0000313|Proteomes:UP000053097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24508170; DOI=10.1016/j.cub.2014.01.018;
RA Oxley P.R., Ji L., Fetter-Pruneda I., McKenzie S.K., Li C., Hu H.,
RA Zhang G., Kronauer D.J.;
RT "The genome of the clonal raider ant Cerapachys biroi.";
RL Curr. Biol. 24:451-458(2014).
RN [2] {ECO:0000313|EMBL:RLU16488.1, ECO:0000313|Proteomes:UP000279307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Clonal line C1 {ECO:0000313|EMBL:RLU16488.1};
RX PubMed=30249741; DOI=10.1101/gr.237123.118;
RA McKenzie S.K., Kronauer D.J.C.;
RT "The genomic architecture and molecular evolution of ant odorant
RT receptors.";
RL Genome Res. 28:1757-1765(2018).
RN [3] {ECO:0000313|EMBL:RLU16488.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Clonal line C1 {ECO:0000313|EMBL:RLU16488.1};
RA Mckenzie S.K., Kronauer D.J.C.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC natural killer/NK cells receptor NCR3 and stimulates NK cells
CC cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC neighboring tumor cells and immature myeloid dendritic cells (DC).
CC {ECO:0000256|ARBA:ARBA00002067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR EMBL; KK107078; EZA60343.1; -; Genomic_DNA.
DR EMBL; QOIP01000011; RLU16488.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A026WWX7; -.
DR STRING; 2015173.A0A026WWX7; -.
DR EnsemblMetazoa; XM_011330666.3; XP_011328968.1; LOC105274489.
DR OMA; RTNVFPF; -.
DR OrthoDB; 3177594at2759; -.
DR Proteomes; UP000053097; Unassembled WGS sequence.
DR Proteomes; UP000279307; Chromosome 11.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053097};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 2..64
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 73..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 132582 MW; 6D56EB88C630F9AA CRC64;
MIDLTVKTLD SQNHVFSLDD DQITVRGFKE HIAEAVAVPA DSQRLIYCGR VLQDEKKLND
YDVNGKVIHL VQRAPPQPGQ HGSDGGQTPG QNNRQGWQNP QRPQYRVTRA QMHGNAMYLG
AMSVPAEIVE GHGIPQLSNS LSGSRLNHAG RMLDRISELI DRLDDPNAPP LHPTPSELNQ
PTAPQQPAQH QQESDVEQND GNDGAVRFAE AAVAAITAAL SAAGARGVTL LRGNNYNGPS
TRSTSDANEN QSDAESQSQS QSEPQAQQPP SQPQTQPQAQ QSQQQQQPQQ APPPSAETGA
SSMNAGQNRR AQQQDLPRPP QMAGLLQRLS NVQERMRPYL ERYIMLMLLD PSLPPGPGPN
TVEESQRIVD GVSEVLHLMS HCCHALSDII VDMSQPPPRN LRCRPIIVQH SAILQPGIPI
QVEAHISLNG RGTNNNNSSD EATESGNQQA QSENAESTTT SPRVSTEESN QERESESTAQ
SQAERPQQEQ GQSPFGTVFN LPNNVEVLME VSNVDGGSGN EQNAGNENNN NGNARRTNVF
PFGTAPPPYF MRNFMQAVAG AHMMHGGIAT TNISTRSTPV TTVAAQQGIP ASAMDSGTTN
AGQSTQARSN SGTHPTTATQ TRSTSRPHVF HHHAHPMGLG MSIGLGLDFD PYLPCNSHHV
YRTPASTAPS GGAATAGVTT SSQTTTRTMP TTTADAQNQT ATTSTTTTSA TNATSATNTE
TANNTPFVNM LQQILSQSAG GQTQSNISIN SNALNLLASL GNMIQMFGSN IHVWDTGFVN
NSSMGSAVTL ADLFSRPEGP GLSLDIFTSN LSGRGSFLVD LFAVLAQNMT LDGLIRLRLG
QSEPIARLRR PLQEFLQYTF PRASSTDLEP RVIERLLLQL QPHIRNLLAS EEDTSGRSGS
RIDIYATVES LIARHVKDIL RILFDNSVDD ARFGQEILNI LIELCNQICM VLRYSLRGGQ
AGLEAIALRF VSDVLIDGSN PPLRQWMLNG FIAQLRNYFL RIPQLPDSEI VPLLVYKDAS
SQQSSVSSAS TRQSTQAQSQ DEPMETETVE QQTVRESSVP EDREEIPETF PGHEALPSDW
VPIIARDSVR QRRQLQQMQG VTTNSGVTTF SDAYLGGLPT KRRKLIEQQK PRLLVSPTPN
HHSTIAASME RLVREGVGRA GVEEVEGAAV AVAADPAVRR AFGQAIRDCL NPCRYGTPDF
PDPLRFPNAT KYFADQERPP K
//
